eF-site ID 3cmm-C PDB Code 3cmm Chain C click to enlarge Title Crystal Structure of the Uba1-Ubiquitin Complex Classification LIGASE/PROTEIN BINDING Compound Ubiquitin-activating enzyme E1 1 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (UBIQ_YEAST) Sequence C:  AGEIDESLYSRQLYVLGKEAMLKMQTSNVLILGLKGLGVE IAKNVVLAGVKSMTVFDPEPVQLADLSTQFFLTEKDIGQK RGDVTRAKLAELNAYVPVNVLDSLDDVTQLSQFQVVVATD TVSLEDKVKINEFCHSSGIRFISSETRGLFGNTFVDLGDE FTVLDPTGEEPRTGMVSDIEPDGTVTMLDDNRHGLEDGNF VRFSEVEGLDKLNDGTLFKVEVLGPFAFRIGSVKEYGEYK KGGIFTEVKVPRKISFKSLKQQLSNPEFVFSDFAKFDRAA QLHLGFQALHQFAVRHNGELPRTMNDEDANELIKLVTDLS VQQPEVLGEGVDVNEDLIKELSYQARGDIPGVVAFFGGLV AQEVLKACSGKFTPLKQFMYFDSLESLPDPKNFPRNEKTT QPVNSRYDNQIAVFGLDFQKKIANSKVFLVGSGAIGCEML KNWALLGLGSGSDGYIVVTDNDSIEKSNLNRQFLFRPKDV GKNKSEVAAEAVCAMNPDLKGKINAKIDKVGPETEEIFND SFWESLDFVTNALDNVDARTYVDRRCVFYRKPLLESGTLG TKGNTQVIIPRLTESYSSSRDPPEKSIPLCTLRSFPNKID HTIAWAKSLFQGYFTDSAENVNMYLTQPNFVEQTLKQSGD VKGVLESISDSLSSKPHNFEDCIKWARLEFEKKFNHDIKQ LLFNFPKDAKTSNGEPFWSGAKRAPTPLEFDIYNNDHFHF VVAGASLRAYNYGIKSDDSNSKPNVDEYKSVIDHMIIPEF TPNANLKIQVNDDDPGSDEIDQLVSSLPDPSTLAGFKLEP VDFEKDDDTNHHIEFITACSNCRAQNYFIETADRQKTKFI AGRIIPAIATTTSLVTGLVNLELYKLIDNKTDIEQYKNGF VNLALPFFGFSEPIASPKGEYNNKKYDKIWDRFDIKGDIK LSDLIEHFEKDEGLEITMLSYGVSLLYASFFPPKKLKERL NLPITQLVKLVTKKDIPAHVSTMILEICADDKEGEDVEVP FITIHL Description Functional site 1) chain C residue 316 type sequence D description BINDING SITE FOR RESIDUE PRO C 5129 source : AC2 2) chain C residue 320 type sequence N description BINDING SITE FOR RESIDUE PRO C 5129 source : AC2 3) chain C residue 323 type sequence I description BINDING SITE FOR RESIDUE PRO C 5129 source : AC2 4) chain C residue 349 type sequence K description BINDING SITE FOR RESIDUE PRO C 5129 source : AC2 5) chain C residue 21 type catalytic sequence R description 307 source MCSA : MCSA3 6) chain C residue 481 type catalytic sequence R description 307 source MCSA : MCSA3 7) chain C residue 544 type catalytic sequence D description 307 source MCSA : MCSA3 8) chain C residue 600 type catalytic sequence C description 307 source MCSA : MCSA3 9) chain C residue 601 type catalytic sequence T description 307 source MCSA : MCSA3 10) chain C residue 603 type catalytic sequence R description 307 source MCSA : MCSA3 11) chain C residue 781 type catalytic sequence N description 307 source MCSA : MCSA3 12) chain C residue 782 type catalytic sequence D description 307 source MCSA : MCSA3 13) chain C residue 600 type catalytic sequence C description 939 source MCSA : MCSA4 14) chain C residue 601 type catalytic sequence T description 939 source MCSA : MCSA4 15) chain C residue 603 type catalytic sequence R description 939 source MCSA : MCSA4 16) chain C residue 781 type catalytic sequence N description 939 source MCSA : MCSA4 17) chain C residue 782 type catalytic sequence D description 939 source MCSA : MCSA4 18) chain C residue 544 type CROSSLNK sequence D description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 19) chain C residue 444 type CROSSLNK sequence A description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 20) chain C residue 470 type CROSSLNK sequence D description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 21) chain C residue 481 type CROSSLNK sequence R description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 22) chain C residue 494 type CROSSLNK sequence K description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 23) chain C residue 914 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI4 24) chain C residue 595 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI5 25) chain C residue 608 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI5

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