eF-site ID 3cmm-A PDB Code 3cmm Chain A click to enlarge Title Crystal Structure of the Uba1-Ubiquitin Complex Classification LIGASE/PROTEIN BINDING Compound Ubiquitin-activating enzyme E1 1 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (UBIQ_YEAST) Sequence A:  GEIDESLYSRQLYVLGKEAMLKMQTSNVLILGLKGLGVEI AKNVVLAGVKSMTVFDPEPVQLADLSTQFFLTEKDIGQKR GDVTRAKLAELNAYVPVNVLDSLDDVTQLSQFQVVVATDT VSLEDKVKINEFCHSSGIRFISSETRGLFGNTFVDLGDEF TVLDPTGEEPRTGMVSDIEPDGTVTMLDDNRHGLEDGNFV RFSEVEGLDKLNDGTLFKVEVLGPFAFRIGSVKEYGEYKK GGIFTEVKVPRKISFKSLKQQLSNPEFVFSDFAKFDRAAQ LHLGFQALHQFAVRHNGELPRTMNDEDANELIKLVTDLSV QQPEVLGEGVDVNEDLIKELSYQARGDIPGVVAFFGGLVA QEVLKACSGKFTPLKQFMYFDSLESLPDPKNFPRNEKTTQ PVNSRYDNQIAVFGLDFQKKIANSKVFLVGSGAIGCEMLK NWALLGLGSGSDGYIVVTDNDSIEKSNLNRQFLFRPKDVG KNKSEVAAEAVCAMNPDLKGKINAKIDKVGPETEEIFNDS FWESLDFVTNALDNVDARTYVDRRCVFYRKPLLESGTLGT KGNTQVIIPRLTESYSSSRDPPEKSIPLCTLRSFPNKIDH TIAWAKSLFQGYFTDSAENVNMYLTQPNFVEQTLKDVKGV LESISDSLSSKPHNFEDCIKWARLEFEKKFNHDIKQLLFN FPKDAKTSNGEPFWSGAKRAPTPLEFDIYNNDHFHFVVAG ASLRAYNYGIKSDDSNSKPNVDEYKSVIDHMIIPEFTPNA NLKIQVNDDDPDPEIDQLVSSLPDPSTLAGFKLEPVDFEK DDDTNHHIEFITACSNCRAQNYFIETADRQKTKFIAGRII PAIATTTSLVTGLVNLELYKLIDNKTDIEQYKNGFVNLAL PFFGFSEPIASPKGEYNNKKYDKIWDRFDIKGDIKLSDLI EHFEKDEGLEITMLSYGVSLLYASFFPPKKLKERLNLPIT QLVKLVTKKDIPAHVSTMILEICADDKEGEDVEVPFITIH L Description Functional site 1) chain A residue 316 type sequence D description BINDING SITE FOR RESIDUE PRO A 5119 source : AC1 2) chain A residue 320 type sequence N description BINDING SITE FOR RESIDUE PRO A 5119 source : AC1 3) chain A residue 21 type catalytic sequence R description 307 source MCSA : MCSA1 4) chain A residue 481 type catalytic sequence R description 307 source MCSA : MCSA1 5) chain A residue 544 type catalytic sequence D description 307 source MCSA : MCSA1 6) chain A residue 600 type catalytic sequence C description 307 source MCSA : MCSA1 7) chain A residue 601 type catalytic sequence T description 307 source MCSA : MCSA1 8) chain A residue 603 type catalytic sequence R description 307 source MCSA : MCSA1 9) chain A residue 781 type catalytic sequence N description 307 source MCSA : MCSA1 10) chain A residue 782 type catalytic sequence D description 307 source MCSA : MCSA1 11) chain A residue 600 type catalytic sequence C description 939 source MCSA : MCSA2 12) chain A residue 601 type catalytic sequence T description 939 source MCSA : MCSA2 13) chain A residue 603 type catalytic sequence R description 939 source MCSA : MCSA2 14) chain A residue 781 type catalytic sequence N description 939 source MCSA : MCSA2 15) chain A residue 782 type catalytic sequence D description 939 source MCSA : MCSA2 16) chain A residue 914 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI4 17) chain A residue 595 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI5 18) chain A residue 608 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI5 19) chain A residue 376-384 type prosite sequence KACSGKFTP description UBIQUITIN_ACTIVAT_1 Ubiquitin-activating enzyme signature 1. KACSGKFtP source prosite : PS00536 20) chain A residue 598-606 type prosite sequence PLCTLRSFP description UBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PLCTLRsFP source prosite : PS00865 21) chain A residue 444 type CROSSLNK sequence A description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 481 type CROSSLNK sequence R description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 544 type CROSSLNK sequence D description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI2

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