eF-site ID 3cmc-R PDB Code 3cmc Chain R click to enlarge Title Thioacylenzyme intermediate of Bacillus stearothermophilus phosphorylating GAPDH Classification OXIDOREDUCTASE Compound Glyceraldehyde-3-phosphate dehydrogenase Source null (G3P_BACST) Sequence R:  AVKVGINGFGRIGRNVFRAALKNPDIEVVAVNDLTDANTL AHLLKYDSVHGRLDAEVSVNGNNLVVNGKEIIVKAERDPE NLAWGEIGVDIVVESTGRFTKREDAAKHLEAGAKKVIISA PAKNEDITIVMGVNQDKYDPKAHHVISNASCTTNCLAPFA KVLHEQFGIVRGMMTTVHSYTNDQRILDLPHKDLRRARAA AESIIPTTTGAAKAVALVLPELKGKLNGMAMRVPTPNVSV VDLVAELEKEVTVEEVNAALKAAAEGELKGILAYSEEPLV SRDYNGSTVSSTIDALSTMVIDGKMVKVVSWYDNETGYSH RVVDLAAYIASKGL Description (1)  Glyceraldehyde-3-phosphate dehydrogenase (E.C.1.2.1.12) Functional site 1) chain R residue 148 type sequence S description BINDING SITE FOR RESIDUE SO4 R 401 source : AC4 2) chain R residue 207 type sequence T description BINDING SITE FOR RESIDUE SO4 R 401 source : AC4 3) chain R residue 208 type sequence T description BINDING SITE FOR RESIDUE SO4 R 401 source : AC4 4) chain R residue 209 type sequence G description BINDING SITE FOR RESIDUE SO4 R 401 source : AC4 5) chain R residue 210 type sequence A description BINDING SITE FOR RESIDUE SO4 R 401 source : AC4 6) chain R residue 179 type sequence T description BINDING SITE FOR RESIDUE SO4 R 402 source : AC8 7) chain R residue 181 type sequence D description BINDING SITE FOR RESIDUE SO4 R 402 source : AC8 8) chain R residue 195 type sequence R description BINDING SITE FOR RESIDUE SO4 R 402 source : AC8 9) chain R residue 231 type sequence R description BINDING SITE FOR RESIDUE SO4 R 402 source : AC8 10) chain R residue 169 type sequence R description BINDING SITE FOR RESIDUE SO4 R 403 source : BC2 11) chain R residue 52 type sequence R description BINDING SITE FOR RESIDUE SO4 R 404 source : BC4 12) chain R residue 58 type sequence S description BINDING SITE FOR RESIDUE SO4 R 405 source : BC5 13) chain R residue 183 type sequence R description BINDING SITE FOR RESIDUE SO4 R 406 source : BC7 14) chain R residue 190 type sequence H description BINDING SITE FOR RESIDUE SO4 R 406 source : BC7 15) chain R residue 191 type sequence K description BINDING SITE FOR RESIDUE SO4 R 406 source : BC7 16) chain R residue 109 type sequence L description BINDING SITE FOR RESIDUE SO4 R 407 source : BC8 17) chain R residue 112 type sequence G description BINDING SITE FOR RESIDUE SO4 R 407 source : BC8 18) chain R residue 113 type sequence A description BINDING SITE FOR RESIDUE SO4 R 407 source : BC8 19) chain R residue 114 type sequence K description BINDING SITE FOR RESIDUE SO4 R 407 source : BC8 20) chain R residue 148 type sequence S description BINDING SITE FOR RESIDUE G3H R 400 source : CC4 21) chain R residue 149 type sequence C description BINDING SITE FOR RESIDUE G3H R 400 source : CC4 22) chain R residue 150 type sequence T description BINDING SITE FOR RESIDUE G3H R 400 source : CC4 23) chain R residue 176 type sequence H description BINDING SITE FOR RESIDUE G3H R 400 source : CC4 24) chain R residue 179 type sequence T description BINDING SITE FOR RESIDUE G3H R 400 source : CC4 25) chain R residue 208 type sequence T description BINDING SITE FOR RESIDUE G3H R 400 source : CC4 26) chain R residue 209 type sequence G description BINDING SITE FOR RESIDUE G3H R 400 source : CC4 27) chain R residue 231 type sequence R description BINDING SITE FOR RESIDUE G3H R 400 source : CC4 28) chain R residue 187 type sequence L description BINDING SITE FOR RESIDUE NAD O 407 source : CC5 29) chain R residue 7 type sequence G description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 30) chain R residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 31) chain R residue 10 type sequence R description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 32) chain R residue 11 type sequence I description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 33) chain R residue 31 type sequence N description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 34) chain R residue 32 type sequence D description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 35) chain R residue 33 type sequence L description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 36) chain R residue 77 type sequence R description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 37) chain R residue 95 type sequence S description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 38) chain R residue 96 type sequence T description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 39) chain R residue 97 type sequence G description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 40) chain R residue 98 type sequence R description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 41) chain R residue 99 type sequence F description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 42) chain R residue 119 type sequence S description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 43) chain R residue 120 type sequence A description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 44) chain R residue 180 type sequence N description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 45) chain R residue 313 type sequence N description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 46) chain R residue 317 type sequence Y description BINDING SITE FOR RESIDUE NAD R 408 source : CC8 47) chain R residue 303 type sequence K description BINDING SITE FOR RESIDUE GOL R 409 source : DC1 48) chain R residue 134 type sequence Q description BINDING SITE FOR RESIDUE GOL R 410 source : DC5 49) chain R residue 135 type sequence D description BINDING SITE FOR RESIDUE GOL R 410 source : DC5 50) chain R residue 281 type sequence R description BINDING SITE FOR RESIDUE GOL P 407 source : DC8 51) chain R residue 149 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:18480053, ECO:0000305|PubMed:12569100 source Swiss-Prot : SWS_FT_FI1 52) chain R residue 10 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 53) chain R residue 32 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 54) chain R residue 77 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 55) chain R residue 119 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 56) chain R residue 180 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 57) chain R residue 313 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 58) chain R residue 148 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3210237, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI3 59) chain R residue 179 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3210237, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI3 60) chain R residue 231 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3210237, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI3 61) chain R residue 195 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI4 62) chain R residue 208 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3210237, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI5 63) chain R residue 176 type SITE sequence H description Activates thiol group during catalysis => ECO:0000250|UniProtKB:Q6GIL8 source Swiss-Prot : SWS_FT_FI6

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