eF-site ID 3cmc-P PDB Code 3cmc Chain P click to enlarge Title Thioacylenzyme intermediate of Bacillus stearothermophilus phosphorylating GAPDH Classification OXIDOREDUCTASE Compound Glyceraldehyde-3-phosphate dehydrogenase Source Geobacillus stearothermophilus (Bacillus stearothermophilus) (G3P_BACST) Sequence P:  AVKVGINGFGRIGRNVFRAALKNPDIEVVAVNDLTDANTL AHLLKYDSVHGRLDAEVSVNGNNLVVNGKEIIVKAERDPE NLAWGEIGVDIVVESTGRFTKREDAAKHLEAGAKKVIISA PAKNEDITIVMGVNQDKYDPKAHHVISNASCTTNCLAPFA KVLHEQFGIVRGMMTTVHSYTNDQRILDLPHKDLRRARAA AESIIPTTTGAAKAVALVLPELKGKLNGMAMRVPTPNVSV VDLVAELEKEVTVEEVNAALKAAAEGELKGILAYSEEPLV SRDYNGSTVSSTIDALSTMVIDGKMVKVVSWYDNETGYSH RVVDLAAYIASKGL Description (1)  Glyceraldehyde-3-phosphate dehydrogenase (E.C.1.2.1.12) Functional site 1) chain P residue 121 type sequence P description BINDING SITE FOR RESIDUE SO4 P 401 source : AC2 2) chain P residue 148 type sequence S description BINDING SITE FOR RESIDUE SO4 P 401 source : AC2 3) chain P residue 207 type sequence T description BINDING SITE FOR RESIDUE SO4 P 401 source : AC2 4) chain P residue 208 type sequence T description BINDING SITE FOR RESIDUE SO4 P 401 source : AC2 5) chain P residue 209 type sequence G description BINDING SITE FOR RESIDUE SO4 P 401 source : AC2 6) chain P residue 210 type sequence A description BINDING SITE FOR RESIDUE SO4 P 401 source : AC2 7) chain P residue 179 type sequence T description BINDING SITE FOR RESIDUE SO4 P 402 source : AC6 8) chain P residue 181 type sequence D description BINDING SITE FOR RESIDUE SO4 P 402 source : AC6 9) chain P residue 195 type sequence R description BINDING SITE FOR RESIDUE SO4 P 402 source : AC6 10) chain P residue 231 type sequence R description BINDING SITE FOR RESIDUE SO4 P 402 source : AC6 11) chain P residue 303 type sequence K description BINDING SITE FOR RESIDUE SO4 O 403 source : AC9 12) chain P residue 138 type sequence D description BINDING SITE FOR RESIDUE SO4 R 407 source : BC8 13) chain P residue 139 type sequence K description BINDING SITE FOR RESIDUE SO4 R 407 source : BC8 14) chain P residue 148 type sequence S description BINDING SITE FOR RESIDUE G3H P 400 source : CC2 15) chain P residue 149 type sequence C description BINDING SITE FOR RESIDUE G3H P 400 source : CC2 16) chain P residue 150 type sequence T description BINDING SITE FOR RESIDUE G3H P 400 source : CC2 17) chain P residue 176 type sequence H description BINDING SITE FOR RESIDUE G3H P 400 source : CC2 18) chain P residue 208 type sequence T description BINDING SITE FOR RESIDUE G3H P 400 source : CC2 19) chain P residue 209 type sequence G description BINDING SITE FOR RESIDUE G3H P 400 source : CC2 20) chain P residue 231 type sequence R description BINDING SITE FOR RESIDUE G3H P 400 source : CC2 21) chain P residue 7 type sequence G description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 22) chain P residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 23) chain P residue 10 type sequence R description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 24) chain P residue 11 type sequence I description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 25) chain P residue 31 type sequence N description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 26) chain P residue 32 type sequence D description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 27) chain P residue 33 type sequence L description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 28) chain P residue 77 type sequence R description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 29) chain P residue 95 type sequence S description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 30) chain P residue 96 type sequence T description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 31) chain P residue 97 type sequence G description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 32) chain P residue 119 type sequence S description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 33) chain P residue 120 type sequence A description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 34) chain P residue 180 type sequence N description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 35) chain P residue 313 type sequence N description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 36) chain P residue 317 type sequence Y description BINDING SITE FOR RESIDUE NAD P 403 source : CC6 37) chain P residue 131 type sequence G description BINDING SITE FOR RESIDUE GOL P 404 source : DC2 38) chain P residue 134 type sequence Q description BINDING SITE FOR RESIDUE GOL P 404 source : DC2 39) chain P residue 135 type sequence D description BINDING SITE FOR RESIDUE GOL P 404 source : DC2 40) chain P residue 159 type sequence K description BINDING SITE FOR RESIDUE GOL P 404 source : DC2 41) chain P residue 181 type sequence D description BINDING SITE FOR RESIDUE GOL P 405 source : DC3 42) chain P residue 183 type sequence R description BINDING SITE FOR RESIDUE GOL P 405 source : DC3 43) chain P residue 188 type sequence P description BINDING SITE FOR RESIDUE GOL P 405 source : DC3 44) chain P residue 190 type sequence H description BINDING SITE FOR RESIDUE GOL P 405 source : DC3 45) chain P residue 191 type sequence K description BINDING SITE FOR RESIDUE GOL P 405 source : DC3 46) chain P residue 169 type sequence R description BINDING SITE FOR RESIDUE GOL O 408 source : DC4 47) chain P residue 212 type sequence K description BINDING SITE FOR RESIDUE GOL P 406 source : DC6 48) chain P residue 215 type sequence A description BINDING SITE FOR RESIDUE GOL P 406 source : DC6 49) chain P residue 223 type sequence G description BINDING SITE FOR RESIDUE GOL P 406 source : DC6 50) chain P residue 50 type sequence H description BINDING SITE FOR RESIDUE GOL P 407 source : DC8 51) chain P residue 51 type sequence G description BINDING SITE FOR RESIDUE GOL P 407 source : DC8 52) chain P residue 208 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3210237, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI5 53) chain P residue 149 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:18480053, ECO:0000305|PubMed:12569100 source Swiss-Prot : SWS_FT_FI1 54) chain P residue 119 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 55) chain P residue 180 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 56) chain P residue 313 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 57) chain P residue 10 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 58) chain P residue 32 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 59) chain P residue 77 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI2 60) chain P residue 148 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3210237, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI3 61) chain P residue 179 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3210237, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI3 62) chain P residue 231 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:3210237, ECO:0000269|PubMed:3586018, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI3 63) chain P residue 195 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12569100, ECO:0000269|PubMed:18480053, ECO:0000269|PubMed:9175858 source Swiss-Prot : SWS_FT_FI4 64) chain P residue 176 type SITE sequence H description Activates thiol group during catalysis => ECO:0000250|UniProtKB:Q6GIL8 source Swiss-Prot : SWS_FT_FI6

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