eF-site ID 3cl2-C PDB Code 3cl2 Chain C click to enlarge Title N1 Neuraminidase N294S + Oseltamivir Classification VIRAL PROTEIN, HYDROLASE Compound Neuraminidase Source (Q6DPL2_9INFA) Sequence C:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY PNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVF GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS ISFCGVNSDTVGWSWPDGAELPFTI Description (1)  Neuraminidase (E.C.3.2.1.18) Functional site 1) chain C residue 118 type sequence R description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 2) chain C residue 119 type sequence E description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 3) chain C residue 151 type sequence D description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 4) chain C residue 152 type sequence R description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 5) chain C residue 178 type sequence W description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 6) chain C residue 276 type sequence E description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 7) chain C residue 277 type sequence E description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 8) chain C residue 292 type sequence R description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 9) chain C residue 347 type sequence Y description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 10) chain C residue 371 type sequence R description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 11) chain C residue 406 type sequence Y description BINDING SITE FOR RESIDUE G39 C 802 source : AC3 12) chain C residue 151 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI1 13) chain C residue 406 type ACT_SITE sequence Y description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI2 14) chain C residue 118 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 15) chain C residue 152 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 16) chain C residue 276 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 17) chain C residue 292 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 18) chain C residue 371 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 19) chain C residue 293 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 20) chain C residue 297 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 21) chain C residue 324 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 22) chain C residue 345 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI5 23) chain C residue 347 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ source Swiss-Prot : SWS_FT_FI6

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