eF-site ID 3cl2-A PDB Code 3cl2 Chain A click to enlarge Title N1 Neuraminidase N294S + Oseltamivir Classification VIRAL PROTEIN, HYDROLASE Compound Neuraminidase Source (Q6DPL2_9INFA) Sequence A:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY PNAGEITCVCRDSWHGSNRPWVSFNQNLEYQIGYICSGVF GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS ISFCGVNSDTVGWSWPDGAELPFTI Description (1)  Neuraminidase (E.C.3.2.1.18) Functional site 1) chain A residue 118 type sequence R description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 2) chain A residue 119 type sequence E description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 3) chain A residue 151 type sequence D description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 4) chain A residue 152 type sequence R description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 5) chain A residue 246 type sequence S description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 6) chain A residue 292 type sequence R description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 7) chain A residue 347 type sequence Y description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 8) chain A residue 371 type sequence R description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 9) chain A residue 406 type sequence Y description BINDING SITE FOR RESIDUE G39 A 800 source : AC1 10) chain A residue 151 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 406 type ACT_SITE sequence Y description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 118 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 152 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 276 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 15) chain A residue 292 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 371 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_04071 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 293 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 18) chain A residue 297 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 324 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI4 20) chain A residue 345 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0 source Swiss-Prot : SWS_FT_FI5 21) chain A residue 347 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ source Swiss-Prot : SWS_FT_FI6

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