|
|
eF-site ID
|
3cjc-D |
|
PDB Code
|
3cjc |
|
Chain
|
D |
|
click to enlarge
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Title
|
Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with DNase I and Gelsolin-segment 1 |
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Classification
|
Structural protein/Hydrolase |
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Compound
|
Actin, alpha skeletal muscle |
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Source
|
ORGANISM_COMMON: rabbit; ORGANISM_SCIENTIFIC: Oryctolagus cuniculus; |
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Sequence
|
D: |
LKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQEV
RDSHLVAVGKLLDYLNQDDPNTYHYVVSEPLGRNSYKERY
LFLFRPNKVSVLDTYQYDDGCCGNDSFSREPAVVKFSSHS
TKVKEFAIVALHSAPSDAVAEINSLYDVYLDVQQKWHLND
VMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSADT
TATSTNCAYDRIVVAGSLLQSSVVPGSAAPFDFQAAYGLS
NEMALAISDHYPVEVTLT
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Description
|
(1) |
Actin, alpha skeletal muscle, Deoxyribonuclease-1 (E.C.3.1.21.1), Gelsolin
|
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Functional site
|
|
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1)
|
chain |
D |
| residue |
39 |
| type |
catalytic |
| sequence |
E
|
| description |
41
|
| source |
MCSA : MCSA1
|
|
|
2)
|
chain |
D |
| residue |
76 |
| type |
catalytic |
| sequence |
Y
|
| description |
41
|
| source |
MCSA : MCSA1
|
|
|
3)
|
chain |
D |
| residue |
78 |
| type |
catalytic |
| sequence |
E
|
| description |
41
|
| source |
MCSA : MCSA1
|
|
|
4)
|
chain |
D |
| residue |
134 |
| type |
catalytic |
| sequence |
H
|
| description |
41
|
| source |
MCSA : MCSA1
|
|
|
5)
|
chain |
D |
| residue |
168 |
| type |
catalytic |
| sequence |
D
|
| description |
41
|
| source |
MCSA : MCSA1
|
|
|
6)
|
chain |
D |
| residue |
212 |
| type |
catalytic |
| sequence |
D
|
| description |
41
|
| source |
MCSA : MCSA1
|
|
|
7)
|
chain |
D |
| residue |
252 |
| type |
catalytic |
| sequence |
H
|
| description |
41
|
| source |
MCSA : MCSA1
|
|
|
8)
|
chain |
D |
| residue |
18 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1748997, ECO:0000269|PubMed:3560229
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
9)
|
chain |
D |
| residue |
167-174 |
| type |
prosite |
| sequence |
GDFNADCS
|
| description |
DNASE_I_2 Deoxyribonuclease I signature 2. GDFNAdCS
|
| source |
prosite : PS00918
|
|
|
10)
|
chain |
D |
| residue |
130-150 |
| type |
prosite |
| sequence |
IVALHSAPSDAVAEINSLYDV
|
| description |
DNASE_I_1 Deoxyribonuclease I signature 1. IVALHSAPsdavaEINsLyDV
|
| source |
prosite : PS00919
|
|
|
11)
|
chain |
D |
| residue |
67 |
| type |
MOD_RES |
| sequence |
V
|
| description |
Phosphotyrosine; by SRC; in vitro => ECO:0000269|PubMed:10210201
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
12)
|
chain |
D |
| residue |
65 |
| type |
SITE |
| sequence |
Y
|
| description |
Nitration by tetranitromethane destroys a Ca(2+) binding site and inactivates enzyme
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
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