eF-site ID 3cf6-ER PDB Code 3cf6 Chain E, R click to enlarge Title Structure of Epac2 in complex with cyclic-AMP and Rap Classification SIGNALING PROTEIN/GTP-BINDING PROTEIN Compound Rap guanine nucleotide exchange factor (GEF) 4 Source Homo sapiens (Human) (RAP1B_HUMAN) Sequence E:  MRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRE LAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIY GKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLR VDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVQKYTVMS GTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMP NTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVL QWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQ LPELEKIVRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASV KEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFT TLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMS SKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTAN LDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAA HCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF YAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMT FTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNHQ DVRSYVRQLNVIDNQRTLSQMSHRLEP R:  EYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRK QVQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQ STFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVG KEQGQNLAFLESSAKSKINVNEIFYDLVRQ Description Functional site 1) chain R residue 11 type sequence S description BINDING SITE FOR RESIDUE SO4 R 168 source : AC1 2) chain R residue 12 type sequence G description BINDING SITE FOR RESIDUE SO4 R 168 source : AC1 3) chain R residue 13 type sequence G description BINDING SITE FOR RESIDUE SO4 R 168 source : AC1 4) chain R residue 15 type sequence G description BINDING SITE FOR RESIDUE SO4 R 168 source : AC1 5) chain R residue 16 type sequence K description BINDING SITE FOR RESIDUE SO4 R 168 source : AC1 6) chain R residue 17 type sequence S description BINDING SITE FOR RESIDUE SO4 R 168 source : AC1 7) chain R residue 59 type sequence A description BINDING SITE FOR RESIDUE SO4 R 168 source : AC1 8) chain E residue 367 type sequence F description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 9) chain E residue 388 type sequence I description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 10) chain E residue 395 type sequence C description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 11) chain E residue 403 type sequence F description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 12) chain E residue 404 type sequence G description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 13) chain E residue 406 type sequence L description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 14) chain E residue 407 type sequence A description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 15) chain E residue 414 type sequence R description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 16) chain E residue 415 type sequence A description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 17) chain E residue 449 type sequence L description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 18) chain E residue 450 type sequence K description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 19) chain E residue 451 type sequence E description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 20) chain E residue 489 type sequence K description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 21) chain E residue 368 type sequence N description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 22) chain E residue 388 type sequence I description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 23) chain E residue 392 type sequence G description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 24) chain E residue 417 type sequence S description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 25) chain E residue 539 type sequence Q description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 26) chain E residue 541 type sequence S description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 27) chain E residue 556 type sequence K description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 28) chain E residue 594 type sequence D description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 29) chain E residue 597 type sequence M description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 30) chain E residue 598 type sequence M description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 31) chain R residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140 source Swiss-Prot : SWS_FT_FI1 32) chain R residue 57 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140 source Swiss-Prot : SWS_FT_FI1 33) chain R residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140 source Swiss-Prot : SWS_FT_FI1 34) chain R residue 147 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140 source Swiss-Prot : SWS_FT_FI1 35) chain E residue 903-932 type prosite sequence IPFMPLLIKDMTFTHEGNKTFIDNLVNFEK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. IPFmPllIkDMtfthegnktfidnl.....................VNFeK source prosite : PS00720 36) chain R residue 39 type MOD_RES sequence S description ADP-ribosylserine; by botulinum toxin => ECO:0000305|PubMed:3141412 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links