eF-site ID 3cf6-E PDB Code 3cf6 Chain E click to enlarge Title Structure of Epac2 in complex with cyclic-AMP and Rap Classification SIGNALING PROTEIN/GTP-BINDING PROTEIN Compound Rap guanine nucleotide exchange factor (GEF) 4 Source Homo sapiens (Human) (RAP1B_HUMAN) Sequence E:  MRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRE LAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIY GKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLR VDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVQKYTVMS GTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMP NTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVL QWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQ LPELEKIVRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASV KEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFT TLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMS SKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTAN LDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAA HCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF YAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMT FTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNHQ DVRSYVRQLNVIDNQRTLSQMSHRLEP Description Functional site 1) chain E residue 367 type sequence F description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 2) chain E residue 388 type sequence I description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 3) chain E residue 395 type sequence C description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 4) chain E residue 403 type sequence F description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 5) chain E residue 404 type sequence G description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 6) chain E residue 406 type sequence L description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 7) chain E residue 407 type sequence A description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 8) chain E residue 414 type sequence R description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 9) chain E residue 415 type sequence A description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 10) chain E residue 449 type sequence L description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 11) chain E residue 450 type sequence K description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 12) chain E residue 451 type sequence E description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 13) chain E residue 489 type sequence K description BINDING SITE FOR RESIDUE SP1 E 2 source : AC2 14) chain E residue 368 type sequence N description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 15) chain E residue 388 type sequence I description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 16) chain E residue 392 type sequence G description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 17) chain E residue 417 type sequence S description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 18) chain E residue 539 type sequence Q description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 19) chain E residue 541 type sequence S description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 20) chain E residue 556 type sequence K description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 21) chain E residue 594 type sequence D description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 22) chain E residue 597 type sequence M description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 23) chain E residue 598 type sequence M description BINDING SITE FOR RESIDUE SP1 E 3 source : AC3 24) chain E residue 903-932 type prosite sequence IPFMPLLIKDMTFTHEGNKTFIDNLVNFEK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. IPFmPllIkDMtfthegnktfidnl.....................VNFeK source prosite : PS00720

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