eF-site ID 3cdw-AH PDB Code 3cdw Chain A, H click to enlarge Title Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate Classification Transferase/VIRAL PROTEIN Compound RNA-directed RNA polymerase 3D-POL Source Coxsackievirus B3 (strain Nancy) (POLG_CXB3N) Sequence A:  GEIEFIESSKDAGFPVINTPSKTKLEPSVFHQVFEGNKEP AVLRSGDPRLKANFEEAIFSKYIGNVNTHVDEYMLEAVDH YAGQLATLDISTEPMKLEDAVYGTEGLEALDLTTSAGYPY VALGIKKRDILSKKTKDLTKLKECMDKYGLNLPMVTYVKD ELRSIEKVAKGKSRLIEASSLNDSVAMRQTFGNLYKTFHL NPGVVTGSAVGCDPDLFWSKIPVMLDGHLIAFDYSGYDAS LSPVWFACLKMLLEKLGYTHKETNYIDYLCNSHHLYRDKH YFVRGGMPSGCSGTSIFNSMINNIIIRTLMLKVYKGIDLD QFRMIAYGDDVIASYPWPIDASLLAEAGKGYGLIMTPADK GECFNEVTWTNATFLKRYFRADEQYPFLVHPVMPMKDIHE SIRWTKDPKNTQDHVRSLCLLAWHNGEHEYEEFIRKIRSV PVGRCLTLPAFSTLRRKWLDSFHHHHHH H:  PNQKPRVPT Description Functional site 1) chain A residue 314 type sequence Y description BINDING SITE FOR RESIDUE CL A 469 source : AC1 2) chain A residue 315 type sequence K description BINDING SITE FOR RESIDUE CL A 469 source : AC1 3) chain A residue 316 type sequence G description BINDING SITE FOR RESIDUE CL A 469 source : AC1 4) chain A residue 220 type sequence K description BINDING SITE FOR RESIDUE CL A 470 source : AC2 5) chain A residue 466 type sequence H description BINDING SITE FOR RESIDUE CL A 470 source : AC2 6) chain A residue 468 type sequence H description BINDING SITE FOR RESIDUE CL A 470 source : AC2 7) chain A residue 35 type sequence E description BINDING SITE FOR RESIDUE CL A 471 source : AC3 8) chain A residue 399 type sequence H description BINDING SITE FOR RESIDUE CL A 471 source : AC3 9) chain A residue 436 type sequence K description BINDING SITE FOR RESIDUE CL A 471 source : AC3 10) chain A residue 212 type sequence C description BINDING SITE FOR RESIDUE CL A 472 source : AC4 11) chain A residue 213 type sequence D description BINDING SITE FOR RESIDUE CL A 472 source : AC4 12) chain A residue 163 type sequence R description BINDING SITE FOR RESIDUE CL A 475 source : AC5 13) chain A residue 167 type sequence K description BINDING SITE FOR RESIDUE CL A 475 source : AC5 14) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE CL A 475 source : AC5 15) chain A residue 20 type sequence P description BINDING SITE FOR RESIDUE ACT A 476 source : AC6 16) chain A residue 21 type sequence S description BINDING SITE FOR RESIDUE ACT A 476 source : AC6 17) chain A residue 22 type sequence K description BINDING SITE FOR RESIDUE ACT A 476 source : AC6 18) chain A residue 22 type sequence K description BINDING SITE FOR RESIDUE ACT A 477 source : AC7 19) chain A residue 44 type sequence R description BINDING SITE FOR RESIDUE ACT A 477 source : AC7 20) chain A residue 425 type sequence N description BINDING SITE FOR RESIDUE ACT A 478 source : AC8 21) chain A residue 426 type sequence G description BINDING SITE FOR RESIDUE ACT A 478 source : AC8 22) chain A residue 427 type sequence E description BINDING SITE FOR RESIDUE ACT A 478 source : AC8 23) chain A residue 428 type sequence H description BINDING SITE FOR RESIDUE ACT A 478 source : AC8 24) chain A residue 429 type sequence E description BINDING SITE FOR RESIDUE ACT A 478 source : AC8 25) chain A residue 132 type sequence S description BINDING SITE FOR RESIDUE ACT A 479 source : AC9 26) chain A residue 133 type sequence K description BINDING SITE FOR RESIDUE ACT A 479 source : AC9 27) chain A residue 134 type sequence K description BINDING SITE FOR RESIDUE ACT A 479 source : AC9 28) chain A residue 68 type sequence T description BINDING SITE FOR RESIDUE ACT A 480 source : BC1 29) chain A residue 247 type sequence A description BINDING SITE FOR RESIDUE ACT A 480 source : BC1 30) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE ACT A 481 source : BC2 31) chain A residue 38 type sequence K description BINDING SITE FOR RESIDUE POP A 482 source : BC3 32) chain A residue 162 type sequence L description BINDING SITE FOR RESIDUE POP A 482 source : BC3 33) chain A residue 163 type sequence R description BINDING SITE FOR RESIDUE POP A 482 source : BC3 34) chain A residue 164 type sequence S description BINDING SITE FOR RESIDUE POP A 482 source : BC3 35) chain A residue 167 type sequence K description BINDING SITE FOR RESIDUE POP A 482 source : BC3 36) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE POP A 482 source : BC3 37) chain A residue 376 type sequence K description BINDING SITE FOR RESIDUE POP A 482 source : BC3 38) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE GOL A 483 source : BC4 39) chain A residue 295 type sequence S description BINDING SITE FOR RESIDUE GOL A 483 source : BC4 40) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE GOL A 483 source : BC4 41) chain A residue 290 type sequence G description BINDING SITE FOR RESIDUE GOL A 484 source : BC5 42) chain A residue 291 type sequence C description BINDING SITE FOR RESIDUE GOL A 484 source : BC5 43) chain A residue 294 type sequence T description BINDING SITE FOR RESIDUE GOL A 484 source : BC5 44) chain A residue 295 type sequence S description BINDING SITE FOR RESIDUE GOL A 484 source : BC5 45) chain A residue 38 type sequence K description BINDING SITE FOR RESIDUE GOL A 485 source : BC6 46) chain A residue 397 type sequence D description BINDING SITE FOR RESIDUE GOL A 485 source : BC6 47) chain A residue 401 type sequence S description BINDING SITE FOR RESIDUE GOL A 485 source : BC6 48) chain A residue 384 type sequence Q description BINDING SITE FOR RESIDUE GOL A 486 source : BC7 49) chain A residue 385 type sequence Y description BINDING SITE FOR RESIDUE GOL A 486 source : BC7 50) chain A residue 455 type sequence R description BINDING SITE FOR RESIDUE GOL A 486 source : BC7 51) chain A residue 459 type sequence L description BINDING SITE FOR RESIDUE GOL A 486 source : BC7 52) chain A residue 452 type sequence S description BINDING SITE FOR RESIDUE GOL A 487 source : BC8 53) chain A residue 453 type sequence T description BINDING SITE FOR RESIDUE GOL A 487 source : BC8 54) chain A residue 456 type sequence R description BINDING SITE FOR RESIDUE GOL A 487 source : BC8 55) chain A residue 416 type sequence R description BINDING SITE FOR RESIDUE GOL A 488 source : BC9 56) chain A residue 449 type sequence P description BINDING SITE FOR RESIDUE GOL A 488 source : BC9 57) chain A residue 450 type sequence A description BINDING SITE FOR RESIDUE GOL A 488 source : BC9 58) chain A residue 453 type sequence T description BINDING SITE FOR RESIDUE GOL A 488 source : BC9 59) chain A residue 212 type sequence C description BINDING SITE FOR RESIDUE GOL A 489 source : CC1 60) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE GOL A 489 source : CC1 61) chain A residue 397 type sequence D description BINDING SITE FOR RESIDUE GOL A 490 source : CC2 62) chain A residue 370 type sequence T description BINDING SITE FOR RESIDUE GOL A 491 source : CC3 63) chain A residue 378 type sequence Y description BINDING SITE FOR RESIDUE GOL A 491 source : CC3 64) chain A residue 380 type sequence R description BINDING SITE FOR RESIDUE GOL A 491 source : CC3 65) chain H residue 14 type sequence P description BINDING SITE FOR RESIDUE GOL A 491 source : CC3 66) chain A residue 151 type sequence N description BINDING SITE FOR RESIDUE GOL A 492 source : CC4 67) chain A residue 261 type sequence K description BINDING SITE FOR RESIDUE GOL A 492 source : CC4 68) chain A residue 264 type sequence N description BINDING SITE FOR RESIDUE GOL A 492 source : CC4 69) chain A residue 246 type sequence F description BINDING SITE FOR RESIDUE GOL A 493 source : CC5 70) chain A residue 247 type sequence A description BINDING SITE FOR RESIDUE GOL A 493 source : CC5 71) chain A residue 266 type sequence I description BINDING SITE FOR RESIDUE GOL A 493 source : CC5 72) chain A residue 267 type sequence D description BINDING SITE FOR RESIDUE GOL A 493 source : CC5 73) chain A residue 270 type sequence C description BINDING SITE FOR RESIDUE GOL A 493 source : CC5 74) chain A residue 271 type sequence N description BINDING SITE FOR RESIDUE GOL A 493 source : CC5 75) chain A residue 3 type sequence I description BINDING SITE FOR RESIDUE GOL A 494 source : CC6 76) chain A residue 6 type sequence I description BINDING SITE FOR RESIDUE GOL A 494 source : CC6 77) chain A residue 55 type sequence E description BINDING SITE FOR RESIDUE GOL A 494 source : CC6 78) chain A residue 279 type sequence K description BINDING SITE FOR RESIDUE GOL A 494 source : CC6 79) chain A residue 281 type sequence Y description BINDING SITE FOR RESIDUE GOL A 494 source : CC6 80) chain A residue 43 type sequence L description BINDING SITE FOR RESIDUE GOL A 495 source : CC7 81) chain A residue 44 type sequence R description BINDING SITE FOR RESIDUE GOL A 495 source : CC7 82) chain A residue 45 type sequence S description BINDING SITE FOR RESIDUE GOL A 495 source : CC7 83) chain A residue 55 type sequence E description BINDING SITE FOR RESIDUE GOL A 495 source : CC7 84) chain A residue 276 type sequence Y description BINDING SITE FOR RESIDUE GOL A 495 source : CC7 85) chain A residue 277 type sequence R description BINDING SITE FOR RESIDUE GOL A 495 source : CC7 86) chain A residue 232 type sequence F description BINDING SITE FOR RESIDUE GOL A 496 source : CC8 87) chain A residue 233 type sequence D description BINDING SITE FOR RESIDUE GOL A 496 source : CC8 88) chain A residue 330 type sequence D description BINDING SITE FOR RESIDUE GOL A 496 source : CC8 89) chain A residue 359 type sequence D description BINDING SITE FOR RESIDUE GOL A 496 source : CC8 90) chain A residue 373 type sequence T description BINDING SITE FOR RESIDUE GOL A 496 source : CC8 91) chain A residue 374 type sequence F description BINDING SITE FOR RESIDUE GOL A 496 source : CC8 92) chain A residue 58 type sequence I description BINDING SITE FOR RESIDUE GOL A 497 source : CC9 93) chain A residue 59 type sequence F description BINDING SITE FOR RESIDUE GOL A 497 source : CC9 94) chain A residue 61 type sequence K description BINDING SITE FOR RESIDUE GOL A 497 source : CC9 95) chain A residue 62 type sequence Y description BINDING SITE FOR RESIDUE GOL A 497 source : CC9 96) chain A residue 239 type sequence A description BINDING SITE FOR RESIDUE GOL A 497 source : CC9 97) chain A residue 61 type sequence K description BINDING SITE FOR RESIDUE GOL A 498 source : DC1 98) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE GOL A 498 source : DC1 99) chain A residue 236 type sequence G description BINDING SITE FOR RESIDUE GOL A 498 source : DC1 100) chain A residue 10 type sequence K description BINDING SITE FOR RESIDUE GOL A 499 source : DC2 101) chain A residue 316 type sequence G description BINDING SITE FOR RESIDUE GOL A 499 source : DC2 102) chain A residue 318 type sequence D description BINDING SITE FOR RESIDUE GOL A 499 source : DC2 103) chain A residue 335 type sequence Y description BINDING SITE FOR RESIDUE GOL A 499 source : DC2 104) chain A residue 337 type sequence W description BINDING SITE FOR RESIDUE GOL A 499 source : DC2 105) chain A residue 107 type sequence L description BINDING SITE FOR RESIDUE GOL A 500 source : DC3 106) chain A residue 188 type sequence R description BINDING SITE FOR RESIDUE GOL A 500 source : DC3 107) chain A residue 195 type sequence Y description BINDING SITE FOR RESIDUE GOL A 500 source : DC3 108) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE GOL A 500 source : DC3 109) chain A residue 292 type sequence S description BINDING SITE FOR RESIDUE GOL A 500 source : DC3 110) chain A residue 293 type sequence G description BINDING SITE FOR RESIDUE GOL A 500 source : DC3 111) chain A residue 31 type sequence H description BINDING SITE FOR RESIDUE GOL A 501 source : DC4 112) chain A residue 36 type sequence G description BINDING SITE FOR RESIDUE GOL A 501 source : DC4 113) chain A residue 403 type sequence R description BINDING SITE FOR RESIDUE GOL A 501 source : DC4 114) chain A residue 404 type sequence W description BINDING SITE FOR RESIDUE GOL A 501 source : DC4 115) chain A residue 381 type sequence A description BINDING SITE FOR RESIDUE GOL A 502 source : DC5 116) chain A residue 382 type sequence D description BINDING SITE FOR RESIDUE GOL A 502 source : DC5 117) chain A residue 383 type sequence E description BINDING SITE FOR RESIDUE GOL A 502 source : DC5 118) chain A residue 390 type sequence H description BINDING SITE FOR RESIDUE GOL A 502 source : DC5 119) chain H residue 10 type sequence K description BINDING SITE FOR RESIDUE GOL A 502 source : DC5 120) chain A residue 426 type sequence G description BINDING SITE FOR RESIDUE GOL A 503 source : DC6 121) chain A residue 427 type sequence E description BINDING SITE FOR RESIDUE GOL A 503 source : DC6 122) chain A residue 428 type sequence H description BINDING SITE FOR RESIDUE GOL A 503 source : DC6 123) chain A residue 451 type sequence F description BINDING SITE FOR RESIDUE GOL A 503 source : DC6 124) chain A residue 12 type sequence A description BINDING SITE FOR RESIDUE GOL A 504 source : DC7 125) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE GOL A 504 source : DC7 126) chain A residue 339 type sequence I description BINDING SITE FOR RESIDUE GOL A 504 source : DC7 127) chain A residue 140 type sequence K description BINDING SITE FOR RESIDUE GOL A 505 source : DC8 128) chain A residue 147 type sequence K description BINDING SITE FOR RESIDUE GOL A 505 source : DC8 129) chain A residue 346 type sequence E description BINDING SITE FOR RESIDUE GOL A 505 source : DC8 130) chain A residue 349 type sequence K description BINDING SITE FOR RESIDUE GOL A 505 source : DC8 131) chain A residue 114 type sequence T description BINDING SITE FOR RESIDUE GOL A 506 source : DC9 132) chain A residue 115 type sequence S description BINDING SITE FOR RESIDUE GOL A 506 source : DC9 133) chain A residue 47 type sequence D description BINDING SITE FOR RESIDUE GOL A 507 source : EC1 134) chain A residue 48 type sequence P description BINDING SITE FOR RESIDUE GOL A 507 source : EC1 135) chain A residue 49 type sequence R description BINDING SITE FOR RESIDUE GOL A 507 source : EC1 136) chain A residue 39 type sequence E description BINDING SITE FOR RESIDUE GOL A 508 source : EC2 137) chain A residue 40 type sequence P description BINDING SITE FOR RESIDUE GOL A 508 source : EC2 138) chain A residue 404 type sequence W description BINDING SITE FOR RESIDUE GOL A 508 source : EC2 139) chain A residue 386 type sequence P description BINDING SITE FOR RESIDUE GOL A 509 source : EC3 140) chain A residue 447 type sequence T description BINDING SITE FOR RESIDUE GOL A 509 source : EC3 141) chain H residue 7 type sequence P description BINDING SITE FOR RESIDUE GOL A 509 source : EC3

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