eF-site ID 3cbl-A PDB Code 3cbl Chain A click to enlarge Title Crystal structure of human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide Classification TRANSFERASE Compound Proto-oncogene tyrosine-protein kinase Fes/Fps Source Homo sapiens (Human) (3CBL) Sequence A:  SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRES QQEYVLSVPRHFIINLYRLFPSIPLLIDHLLSTQQPLVVL HRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNT LVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGV CTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVG DAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMS REEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWS FGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC PDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH Description Functional site 1) chain A residue 567 type sequence I description BINDING SITE FOR RESIDUE STU A 901 source : AC1 2) chain A residue 568 type sequence G description BINDING SITE FOR RESIDUE STU A 901 source : AC1 3) chain A residue 569 type sequence R description BINDING SITE FOR RESIDUE STU A 901 source : AC1 4) chain A residue 588 type sequence A description BINDING SITE FOR RESIDUE STU A 901 source : AC1 5) chain A residue 607 type sequence E description BINDING SITE FOR RESIDUE STU A 901 source : AC1 6) chain A residue 637 type sequence E description BINDING SITE FOR RESIDUE STU A 901 source : AC1 7) chain A residue 638 type sequence L description BINDING SITE FOR RESIDUE STU A 901 source : AC1 8) chain A residue 642 type sequence G description BINDING SITE FOR RESIDUE STU A 901 source : AC1 9) chain A residue 687 type sequence R description BINDING SITE FOR RESIDUE STU A 901 source : AC1 10) chain A residue 690 type sequence L description BINDING SITE FOR RESIDUE STU A 901 source : AC1 11) chain A residue 700 type sequence S description BINDING SITE FOR RESIDUE STU A 901 source : AC1 12) chain A residue 701 type sequence D description BINDING SITE FOR RESIDUE STU A 901 source : AC1 13) chain A residue 583 type sequence D description BINDING SITE FOR RESIDUE STU A 902 source : AC2 14) chain A residue 585 type sequence T description BINDING SITE FOR RESIDUE STU A 902 source : AC2 15) chain A residue 621 type sequence R description BINDING SITE FOR RESIDUE STU A 902 source : AC2 16) chain A residue 622 type sequence L description BINDING SITE FOR RESIDUE STU A 902 source : AC2 17) chain A residue 623 type sequence I description BINDING SITE FOR RESIDUE STU A 902 source : AC2 18) chain A residue 456 type sequence H description BINDING SITE FOR RESIDUE STU A 903 source : AC3 19) chain A residue 553 type sequence K description BINDING SITE FOR RESIDUE STU A 903 source : AC3 20) chain A residue 554 type sequence W description BINDING SITE FOR RESIDUE STU A 903 source : AC3 21) chain A residue 559 type sequence E description BINDING SITE FOR RESIDUE STU A 903 source : AC3 22) chain A residue 581 type sequence R description BINDING SITE FOR RESIDUE STU A 903 source : AC3 23) chain A residue 683 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 567 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 590 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 713 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:18775312, ECO:0000269|PubMed:19382747, ECO:0000269|PubMed:7687763, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 716 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI4 28) chain A residue 567-590 type prosite sequence IGRGNFGEVFSGRLRADNTLVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGNFGEVFsGrlradntl..........VAVK source prosite : PS00107 29) chain A residue 679-691 type prosite sequence CIHRDLAARNCLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNCLV source prosite : PS00109

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