eF-site ID 3c7n-AB PDB Code 3c7n Chain A, B click to enlarge Title Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex Classification CHAPERONE/CHAPERONE Compound Heat shock protein homolog SSE1 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (HSP7C_BOVIN) Sequence A:  MSTPFGLDLGNNNSVLAVARNRGIDIVVNEVSNRSTPSVV GFGPKNRYLGETGKNKQTSNIKNTVANLKRIIGLDYHHPD FEQESKHFTSKLVELDDKKTGAEVRFAGEKHVFSATQLAA MFIDKVKDTVKQDTKANITDVCIAVPPWYTEEQRYNIADA ARIAGLNPVRIVNDVTAAGVSYGIFKTDLPEGEEKPRIVA FVDIGHSSYTCSIMAFKKGQLKVLGTACDKHFGGRDFDLA ITEHFADEFKTKYKIDIRENPKAYNRILTAAEKLKKVLSA NTNAPFSVESVMNDVDVSSQLSREELEELVKPLLERVTEP VTKALAQAKLSAEEVDFVEIIGGTTRIPTLKQSISEAFGK PLSTTLNQDEAIAKGAAFICAIHSPTLRVRPFKFEDIHPY SVSYSWDKQVEDEDHMEVFPAGSSFPSTKLITLNRTGDFS MAASYTDITQLPPNTPEQIANWEITGVQLPEGQDSVPVKL KLRCDPSGLHTIEEAYTIEDIEVEEPIPLPEDAPEDAEQE FKKVTKTVKKDDLTIVAHTFGLDAKKLNELIEKENEMLAQ DKLVAETEDRKNTLEEYIYTLRGKLEEEYAPFASDAEKTK LQGMLNKAEEWLYDEGFDSIKAKYIAKYEELASLGNIIRG RYLAKEEEK B:  KGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYV AFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAV VQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSM VLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAG TIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGG GTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFI AEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASI EIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALR DAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKS INPDEAVAYGAAVQAAILSGDKDLLLLDVTPLSLGIETAG GVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGER AMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILN VSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKA EDEKQRDKVSSKNSLESYAF Description Functional site 1) chain A residue 69 type sequence K description BINDING SITE FOR RESIDUE MG A 667 source : AC1 2) chain B residue 191 type sequence A description BINDING SITE FOR RESIDUE CL B 555 source : AC2 3) chain B residue 193 type sequence R description BINDING SITE FOR RESIDUE CL B 555 source : AC2 4) chain A residue 474 type sequence D description BINDING SITE FOR RESIDUE CL B 556 source : AC3 5) chain B residue 236 type sequence R description BINDING SITE FOR RESIDUE CL B 556 source : AC3 6) chain B residue 13 type sequence T description BINDING SITE FOR RESIDUE MG B 558 source : AC4 7) chain B residue 71 type sequence K description BINDING SITE FOR RESIDUE MG B 558 source : AC4 8) chain B residue 204 type sequence T description BINDING SITE FOR RESIDUE MG B 558 source : AC4 9) chain A residue 12 type sequence N description BINDING SITE FOR RESIDUE SO4 A 668 source : AC5 10) chain A residue 13 type sequence N description BINDING SITE FOR RESIDUE SO4 A 668 source : AC5 11) chain A residue 276 type sequence K description BINDING SITE FOR RESIDUE SO4 A 668 source : AC5 12) chain A residue 33 type sequence N description BINDING SITE FOR RESIDUE SO4 B 559 source : AC6 13) chain A residue 54 type sequence K description BINDING SITE FOR RESIDUE SO4 B 559 source : AC6 14) chain B residue 269 type sequence R description BINDING SITE FOR RESIDUE SO4 B 559 source : AC6 15) chain B residue 272 type sequence R description BINDING SITE FOR RESIDUE SO4 B 559 source : AC6 16) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE SO4 A 669 source : AC7 17) chain A residue 26 type sequence I description BINDING SITE FOR RESIDUE SO4 A 669 source : AC7 18) chain A residue 34 type sequence R description BINDING SITE FOR RESIDUE SO4 A 669 source : AC7 19) chain B residue 25 type sequence K description BINDING SITE FOR RESIDUE SO4 A 669 source : AC7 20) chain B residue 36 type sequence R description BINDING SITE FOR RESIDUE SO4 A 669 source : AC7 21) chain A residue 181 type sequence S description BINDING SITE FOR RESIDUE SO4 A 670 source : AC8 22) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE SO4 A 670 source : AC8 23) chain A residue 366 type sequence L description BINDING SITE FOR RESIDUE SO4 A 670 source : AC8 24) chain A residue 367 type sequence N description BINDING SITE FOR RESIDUE SO4 A 670 source : AC8 25) chain A residue 374 type sequence K description BINDING SITE FOR RESIDUE SO4 A 670 source : AC8 26) chain B residue 27 type sequence E description BINDING SITE FOR RESIDUE SO4 A 670 source : AC8 27) chain B residue 134 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 670 source : AC8 28) chain A residue 8 type sequence D description BINDING SITE FOR RESIDUE BEF A 671 source : AC9 29) chain A residue 10 type sequence G description BINDING SITE FOR RESIDUE BEF A 671 source : AC9 30) chain A residue 203 type sequence D description BINDING SITE FOR RESIDUE BEF A 671 source : AC9 31) chain A residue 372 type sequence I description BINDING SITE FOR RESIDUE BEF A 671 source : AC9 32) chain A residue 10 type sequence G description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 33) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 34) chain A residue 12 type sequence N description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 35) chain A residue 13 type sequence N description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 36) chain A residue 205 type sequence G description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 37) chain A residue 206 type sequence H description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 38) chain A residue 272 type sequence E description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 39) chain A residue 275 type sequence K description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 40) chain A residue 276 type sequence K description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 41) chain A residue 279 type sequence S description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 42) chain A residue 343 type sequence G description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 43) chain A residue 344 type sequence T description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 44) chain A residue 346 type sequence R description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 45) chain A residue 347 type sequence I description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 46) chain B residue 33 type sequence Q description BINDING SITE FOR RESIDUE ADP A 672 source : BC1 47) chain A residue 32 type sequence S description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 48) chain B residue 201 type sequence G description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 49) chain B residue 202 type sequence G description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 50) chain B residue 230 type sequence G description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 51) chain B residue 268 type sequence E description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 52) chain B residue 271 type sequence K description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 53) chain B residue 272 type sequence R description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 54) chain B residue 275 type sequence S description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 55) chain B residue 338 type sequence G description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 56) chain B residue 339 type sequence G description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 57) chain B residue 340 type sequence S description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 58) chain B residue 342 type sequence R description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 59) chain B residue 343 type sequence I description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 60) chain B residue 366 type sequence D description BINDING SITE FOR RESIDUE ADP B 560 source : BC2 61) chain B residue 10 type catalytic sequence D description 656 source MCSA : MCSA1 62) chain B residue 71 type catalytic sequence K description 656 source MCSA : MCSA1 63) chain B residue 175 type catalytic sequence E description 656 source MCSA : MCSA1 64) chain B residue 199 type catalytic sequence D description 656 source MCSA : MCSA1 65) chain B residue 12 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 66) chain B residue 71 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 67) chain B residue 9-16 type prosite sequence IDLGTTYS description HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS source prosite : PS00297 68) chain B residue 334-348 type prosite sequence IVLVGGSTRIPKIQK description HSP70_3 Heat shock hsp70 proteins family signature 3. IvLvGGsTRIPkIqK source prosite : PS01036 69) chain A residue 338-352 type prosite sequence VEIIGGTTRIPTLKQ description HSP70_3 Heat shock hsp70 proteins family signature 3. IvLvGGsTRIPkIqK source prosite : PS01036 70) chain B residue 512 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI9 71) chain B residue 108 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI4 72) chain B residue 328 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI4 73) chain B residue 524 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI4 74) chain B residue 153 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 75) chain B residue 329 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 76) chain B residue 362 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 77) chain B residue 541 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI5 78) chain B residue 246 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI6 79) chain B residue 319 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI7 80) chain B residue 512 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P63017 source Swiss-Prot : SWS_FT_FI7 81) chain B residue 469 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0000250|UniProtKB:P11142 source Swiss-Prot : SWS_FT_FI8 82) chain B residue 14 type BINDING sequence T description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 83) chain B residue 15 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 84) chain B residue 202 type BINDING sequence G description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 85) chain B residue 268 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 86) chain B residue 271 type BINDING sequence K description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 87) chain B residue 275 type BINDING sequence S description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 88) chain B residue 339 type BINDING sequence G description BINDING => ECO:0007744|PDB:2QWL, ECO:0007744|PDB:2QWM, ECO:0007744|PDB:2QWN, ECO:0007744|PDB:2QWO, ECO:0007744|PDB:2QWP, ECO:0007744|PDB:2QWQ source Swiss-Prot : SWS_FT_FI2 89) chain B residue 197-210 type prosite sequence IFDLGGGTFDVSIL description HSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL source prosite : PS00329 90) chain A residue 201-214 type prosite sequence FVDIGHSSYTCSIM description HSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL source prosite : PS00329

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