eF-site ID 3c5j-ABC PDB Code 3c5j Chain A, B, C click to enlarge Title Crystal structure of HLA DR52c Classification MEMBRANE PROTEIN Compound HLA class II histocompatibility antigen, DR alpha chain Source (EF1A2_HUMAN) Sequence A:  EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD CRVEHWGLDEPLLKHWEF B:  RPRFLELLKSECHFFNGTERVRFLERYFHNQEEFVRFDSD VGEYRAVTELGRPVAESWNSQKDLLEQKRGQVDNYCRHNY GVVESFTVQRRVHPQVTVYPAKHHNLLVCSVSGFYPGSIE VRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSG EVYTCQVEHPSVTSPLTVEWRA C:  QVIILNHPGQISA Description (1)  Crystal structure of HLA DR52c Functional site 1) chain B residue 11 type SITE sequence L description Self-peptide antigen => ECO:0000269|PubMed:17583734, ECO:0007744|PDB:2Q6W source Swiss-Prot : SWS_FT_FI1 2) chain B residue 61 type SITE sequence W description Self-peptide antigen => ECO:0000269|PubMed:17583734, ECO:0007744|PDB:2Q6W source Swiss-Prot : SWS_FT_FI1 3) chain B residue 71 type SITE sequence K description Self-peptide antigen => ECO:0000269|PubMed:17583734, ECO:0007744|PDB:2Q6W source Swiss-Prot : SWS_FT_FI1 4) chain B residue 81 type SITE sequence H description Self-peptide antigen => ECO:0000269|PubMed:17583734, ECO:0007744|PDB:2Q6W source Swiss-Prot : SWS_FT_FI1 5) chain B residue 82 type SITE sequence N description Self-peptide antigen => ECO:0000269|PubMed:17583734, ECO:0007744|PDB:2Q6W source Swiss-Prot : SWS_FT_FI1 6) chain A residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 7) chain A residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 8) chain A residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 9) chain A residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 10) chain A residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 11) chain A residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 12) chain B residue 19 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18697946, ECO:0007744|PDB:3C5J source Swiss-Prot : SWS_FT_FI2 13) chain A residue 52 type CARBOHYD sequence A description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18697946, ECO:0007744|PDB:3C5J source Swiss-Prot : SWS_FT_FI2 14) chain A residue 53 type SITE sequence S description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 51 type SITE sequence F description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 161-167 type prosite sequence YDCRVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290 17) chain B residue 171-177 type prosite sequence YTCQVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290

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