eF-site ID 3c4o-AB PDB Code 3c4o Chain A, B click to enlarge Title Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M/S130K/S146M complex Classification HYDROLASE/HYDROLASE INHIBITOR Compound Beta-lactamase SHV-1 Source Klebsiella pneumoniae (BLIP_STRCL) Sequence A:  SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADER FPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDY SPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGP AGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPAS MAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVL PAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRD TPASMAERNQQIAGIGAALIEHWQR B:  AGVMTGAKFTQIQFGMTRQQVLDIAGAENCETGGSFGDSI HCRGHAAGDYYAYATFGFTSAAADAKVDSKSQMKLLAPSA PTLTLAKFNQVTVGMTRAQVLATVGQGSCTTWSEYYPAYP STAGVTLSLKCFDVDGYSSTGFYRGMAHLWFTDGVLQGKR QWDLV Description Functional site 1) chain A residue 271 type sequence S description BINDING SITE FOR RESIDUE SO4 A 507 source : AC1 2) chain A residue 272 type sequence M description BINDING SITE FOR RESIDUE SO4 A 507 source : AC1 3) chain B residue 140 type sequence T description BINDING SITE FOR RESIDUE SO4 A 507 source : AC1 4) chain A residue 198 type sequence R description BINDING SITE FOR RESIDUE SO4 A 508 source : AC2 5) chain A residue 70 type ACT_SITE sequence S description Acyl-ester intermediate source Swiss-Prot : SWS_FT_FI1 6) chain A residue 66-81 type prosite sequence FPMMSTFKVVLCGAVL description BETA_LACTAMASE_A Beta-lactamase class-A active site. FpMMSTfKvvlCGAVL source prosite : PS00146 7) chain A residue 168 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 8) chain A residue 234 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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