|
|
eF-site ID
|
3c4o-A |
|
PDB Code
|
3c4o |
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Chain
|
A |
|
click to enlarge
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Title
|
Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M/S130K/S146M complex |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
|
Beta-lactamase SHV-1 |
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Source
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null (BLIP_STRCL) |
|
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Sequence
|
A: |
SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADER
FPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDY
SPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGP
AGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPAS
MAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVL
PAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRD
TPASMAERNQQIAGIGAALIEHWQR
|
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
271 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE SO4 A 507
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
272 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE SO4 A 507
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
198 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE SO4 A 508
|
| source |
: AC2
|
|
|
4)
|
chain |
A |
| residue |
66-81 |
| type |
prosite |
| sequence |
FPMMSTFKVVLCGAVL
|
| description |
BETA_LACTAMASE_A Beta-lactamase class-A active site. FpMMSTfKvvlCGAVL
|
| source |
prosite : PS00146
|
|
|
5)
|
chain |
A |
| residue |
234 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
A |
| residue |
70 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Acyl-ester intermediate
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
168 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|