eF-site ID 3c4h-A PDB Code 3c4h Chain A click to enlarge Title Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313 Classification TRANSFERASE Compound Poly(ADP-ribose) polymerase 3 Source Homo sapiens (Human) (PARP3_HUMAN) Sequence A:  SMKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKK MPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSS HFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELA QALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPE YKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSK LGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYF ASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTD NPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVP QGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVH Description Functional site 1) chain A residue 384 type sequence H description BINDING SITE FOR RESIDUE DRL A 601 source : AC1 2) chain A residue 385 type sequence G description BINDING SITE FOR RESIDUE DRL A 601 source : AC1 3) chain A residue 414 type sequence Y description BINDING SITE FOR RESIDUE DRL A 601 source : AC1 4) chain A residue 415 type sequence F description BINDING SITE FOR RESIDUE DRL A 601 source : AC1 5) chain A residue 422 type sequence S description BINDING SITE FOR RESIDUE DRL A 601 source : AC1 6) chain A residue 425 type sequence Y description BINDING SITE FOR RESIDUE DRL A 601 source : AC1 7) chain A residue 514 type sequence E description BINDING SITE FOR RESIDUE DRL A 601 source : AC1 8) chain A residue 398 type sequence G description BINDING SITE FOR RESIDUE DMS A 700 source : AC2 9) chain A residue 399 type sequence L description BINDING SITE FOR RESIDUE DMS A 700 source : AC2 10) chain A residue 400 type sequence R description BINDING SITE FOR RESIDUE DMS A 700 source : AC2 11) chain A residue 402 type sequence M description BINDING SITE FOR RESIDUE DMS A 700 source : AC2 12) chain A residue 210 type MOD_RES sequence D description ADP-ribosyl aspartic acid => ECO:0000269|PubMed:25043379 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 231 type MOD_RES sequence E description ADP-ribosyl glutamic acid => ECO:0000269|PubMed:25043379 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 309 type MOD_RES sequence E description ADP-ribosyl glutamic acid => ECO:0000269|PubMed:25043379 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 310 type MOD_RES sequence E description ADP-ribosyl glutamic acid => ECO:0000269|PubMed:25043379 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 344 type MOD_RES sequence E description ADP-ribosyl glutamic acid => ECO:0000269|PubMed:25043379 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 449 type MOD_RES sequence E description ADP-ribosyl glutamic acid => ECO:0000269|PubMed:25043379 source Swiss-Prot : SWS_FT_FI2

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