eF-site ID 3c33-AB PDB Code 3c33 Chain A, B click to enlarge Title Crystal structure of GluR5 ligand-binding core in complex with potassium at 1.78 Angstrom resolution Classification MEMBRANE PROTEIN Compound GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 1 Source Rattus norvegicus (Rat) (GRIK1_RAT) Sequence A:  RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKEL SNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRAD LAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSA DDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSS RQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCN LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKL HMMKEKWWRGNGCP B:  RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKEL SNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRAD LAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTPIDSA DDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSS RQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCN LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKL HMMKEKWWRGNGCP Description Functional site 1) chain B residue 96 type sequence E description BINDING SITE FOR RESIDUE K B 301 source : AC1 2) chain B residue 99 type sequence I description BINDING SITE FOR RESIDUE K B 301 source : AC1 3) chain B residue 100 type sequence D description BINDING SITE FOR RESIDUE K B 301 source : AC1 4) chain A residue 96 type sequence E description BINDING SITE FOR RESIDUE K A 302 source : AC2 5) chain A residue 99 type sequence I description BINDING SITE FOR RESIDUE K A 302 source : AC2 6) chain A residue 100 type sequence D description BINDING SITE FOR RESIDUE K A 302 source : AC2 7) chain A residue 181 type sequence L description BINDING SITE FOR RESIDUE K B 303 source : AC3 8) chain B residue 22 type sequence S description BINDING SITE FOR RESIDUE K B 303 source : AC3 9) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE CL A 304 source : AC4 10) chain A residue 227 type sequence R description BINDING SITE FOR RESIDUE CL A 304 source : AC4 11) chain B residue 103 type sequence K description BINDING SITE FOR RESIDUE CL A 304 source : AC4 12) chain A residue 31 type sequence R description BINDING SITE FOR RESIDUE CL A 305 source : AC5 13) chain A residue 54 type sequence K description BINDING SITE FOR RESIDUE CL A 305 source : AC5 14) chain A residue 55 type sequence L description BINDING SITE FOR RESIDUE CL A 305 source : AC5 15) chain B residue 20 type sequence R description BINDING SITE FOR RESIDUE CL B 306 source : AC6 16) chain B residue 22 type sequence S description BINDING SITE FOR RESIDUE CL B 306 source : AC6 17) chain B residue 31 type sequence R description BINDING SITE FOR RESIDUE CL B 307 source : AC7 18) chain B residue 54 type sequence K description BINDING SITE FOR RESIDUE CL B 307 source : AC7 19) chain B residue 55 type sequence L description BINDING SITE FOR RESIDUE CL B 307 source : AC7 20) chain A residue 13 type sequence E description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 21) chain A residue 61 type sequence Y description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 22) chain A residue 88 type sequence P description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 23) chain A residue 90 type sequence T description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 24) chain A residue 95 type sequence R description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 25) chain A residue 140 type sequence G description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 26) chain A residue 141 type sequence S description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 27) chain A residue 142 type sequence T description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 28) chain A residue 190 type sequence E description BINDING SITE FOR RESIDUE KAI A 401 source : AC8 29) chain B residue 13 type sequence E description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 30) chain B residue 61 type sequence Y description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 31) chain B residue 88 type sequence P description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 32) chain B residue 90 type sequence T description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 33) chain B residue 95 type sequence R description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 34) chain B residue 140 type sequence G description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 35) chain B residue 141 type sequence S description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 36) chain B residue 142 type sequence T description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 37) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE KAI B 401 source : AC9 38) chain B residue 60 type sequence K description BINDING SITE FOR RESIDUE GOL B 402 source : BC1 39) chain B residue 61 type sequence Y description BINDING SITE FOR RESIDUE GOL B 402 source : BC1 40) chain B residue 62 type sequence G description BINDING SITE FOR RESIDUE GOL B 402 source : BC1 41) chain B residue 63 type sequence A description BINDING SITE FOR RESIDUE GOL B 402 source : BC1 42) chain B residue 138 type sequence R description BINDING SITE FOR RESIDUE GOL B 402 source : BC1 43) chain B residue 139 type sequence D description BINDING SITE FOR RESIDUE GOL B 402 source : BC1 44) chain A residue 60 type sequence K description BINDING SITE FOR RESIDUE GOL A 402 source : BC2 45) chain A residue 61 type sequence Y description BINDING SITE FOR RESIDUE GOL A 402 source : BC2 46) chain A residue 62 type sequence G description BINDING SITE FOR RESIDUE GOL A 402 source : BC2 47) chain A residue 63 type sequence A description BINDING SITE FOR RESIDUE GOL A 402 source : BC2 48) chain A residue 138 type sequence R description BINDING SITE FOR RESIDUE GOL A 402 source : BC2 49) chain A residue 139 type sequence D description BINDING SITE FOR RESIDUE GOL A 402 source : BC2 50) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE GOL A 403 source : BC3 51) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE GOL A 403 source : BC3 52) chain B residue 104 type sequence P description BINDING SITE FOR RESIDUE GOL A 403 source : BC3 53) chain B residue 105 type sequence F description BINDING SITE FOR RESIDUE GOL A 403 source : BC3 54) chain B residue 106 type sequence M description BINDING SITE FOR RESIDUE GOL A 403 source : BC3 55) chain B residue 107 type sequence T description BINDING SITE FOR RESIDUE GOL A 403 source : BC3 56) chain B residue 238 type sequence Q description BINDING SITE FOR RESIDUE GOL A 403 source : BC3 57) chain B residue 243 type sequence L description BINDING SITE FOR RESIDUE GOL A 403 source : BC3 58) chain B residue 13 type sequence E description BINDING SITE FOR RESIDUE GOL B 403 source : BC4 59) chain B residue 14 type sequence E description BINDING SITE FOR RESIDUE GOL B 403 source : BC4 60) chain B residue 174 type sequence D description BINDING SITE FOR RESIDUE GOL B 403 source : BC4 61) chain B residue 189 type sequence M description BINDING SITE FOR RESIDUE GOL B 403 source : BC4 62) chain B residue 193 type sequence S description BINDING SITE FOR RESIDUE GOL B 403 source : BC4 63) chain B residue 196 type sequence Y description BINDING SITE FOR RESIDUE GOL B 403 source : BC4 64) chain A residue 88 type BINDING sequence P description BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI1 65) chain A residue 90 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI1 66) chain A residue 141 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI1 67) chain A residue 142 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI1 68) chain B residue 88 type BINDING sequence P description BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI1 69) chain B residue 90 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI1 70) chain B residue 141 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI1 71) chain B residue 142 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI1 72) chain A residue 95 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15710405, ECO:0000269|PubMed:15721240, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI2 73) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15710405, ECO:0000269|PubMed:15721240, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI2 74) chain B residue 95 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15710405, ECO:0000269|PubMed:15721240, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI2 75) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15710405, ECO:0000269|PubMed:15721240, ECO:0007744|PDB:1YCJ source Swiss-Prot : SWS_FT_FI2 76) chain A residue 162 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 77) chain B residue 162 type MOD_RES sequence S description Phosphoserine; by PKC => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 78) chain A residue 198 type MOD_RES sequence T description Phosphothreonine; by PKC => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 79) chain B residue 198 type MOD_RES sequence T description Phosphothreonine; by PKC => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 80) chain A residue 203 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI5 81) chain B residue 203 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI5

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