eF-site ID 3bxs-B PDB Code 3bxs Chain B click to enlarge Title Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism Classification HYDROLASE Compound Protease Source null (POL_HV1A2) Sequence B:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVIEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF Description Functional site 1) chain B residue 101 type sequence P description BINDING SITE FOR RESIDUE SO4 B 601 source : AC1 2) chain B residue 155 type sequence K description BINDING SITE FOR RESIDUE SO4 B 601 source : AC1 3) chain B residue 114 type sequence R description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 4) chain B residue 115 type sequence I description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 5) chain B residue 116 type sequence G description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 6) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 7) chain B residue 108 type sequence R description BINDING SITE FOR RESIDUE DRS A 201 source : AC4 8) chain B residue 123 type sequence L description BINDING SITE FOR RESIDUE DRS A 201 source : AC4 9) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE DRS A 201 source : AC4 10) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE DRS A 201 source : AC4 11) chain B residue 181 type sequence P description BINDING SITE FOR RESIDUE DRS A 201 source : AC4 12) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE DRS B 203 source : AC5 13) chain B residue 128 type sequence A description BINDING SITE FOR RESIDUE DRS B 203 source : AC5 14) chain B residue 129 type sequence D description BINDING SITE FOR RESIDUE DRS B 203 source : AC5 15) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE DRS B 203 source : AC5 16) chain B residue 147 type sequence I description BINDING SITE FOR RESIDUE DRS B 203 source : AC5 17) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE DRS B 203 source : AC5 18) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE DRS B 203 source : AC5 19) chain B residue 125 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 199 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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