eF-site ID 3bxn-ABC PDB Code 3bxn Chain A, B, C click to enlarge Title The high resolution crystal structure of HLA-B*1402 complexed with a Cathepsin A signal sequence peptide, pCatA Classification IMMUNE SYSTEM Compound HLA-B*1402 extracellular domain Source Homo sapiens (Human) (PPGB_HUMAN) Sequence A:  GSHSMRYFYTAVSRPGRGEPRFISVGYVDDTQFVRFDSDA ASPREEPRAPWIEQEGPEYWDRNTQICKTNTQTDRESLRN LRGYYNQSEAGSHTLQWMYGCDVGPDGRLLRGYNQFAYDG KDYIALNEDLSSWTAADTAAQITQRKWEAAREAEQLRAYL EGTCVEWLRRHLENGKETLQRADPPKTHVTHHPISDHEAT LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRT FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP B:  IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC RVNHVTLSQPKIVKWDRDM C:  IRAAPPPLF Description Functional site 1) chain A residue 93 type sequence H description BINDING SITE FOR RESIDUE GOL B 501 source : AC1 2) chain A residue 119 type sequence D description BINDING SITE FOR RESIDUE GOL B 501 source : AC1 3) chain B residue 1 type sequence I description BINDING SITE FOR RESIDUE GOL B 501 source : AC1 4) chain A residue 166 type sequence E description BINDING SITE FOR RESIDUE GOL A 502 source : AC2 5) chain A residue 167 type sequence W description BINDING SITE FOR RESIDUE GOL A 502 source : AC2 6) chain A residue 170 type sequence R description BINDING SITE FOR RESIDUE GOL A 502 source : AC2 7) chain B residue 76 type sequence D description BINDING SITE FOR RESIDUE GOL B 503 source : AC3 8) chain B residue 95 type sequence W description BINDING SITE FOR RESIDUE GOL B 503 source : AC3 9) chain B residue 96 type sequence D description BINDING SITE FOR RESIDUE GOL B 503 source : AC3 10) chain B residue 97 type sequence R description BINDING SITE FOR RESIDUE GOL B 503 source : AC3 11) chain A residue 8 type sequence F description BINDING SITE FOR RESIDUE GOL A 504 source : AC4 12) chain A residue 27 type sequence Y description BINDING SITE FOR RESIDUE GOL A 504 source : AC4 13) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE GOL A 504 source : AC4 14) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE GOL A 504 source : AC4 15) chain B residue 63 type sequence Y description BINDING SITE FOR RESIDUE GOL A 504 source : AC4 16) chain B residue 78-84 type prosite sequence YACRVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH source prosite : PS00290 17) chain A residue 257-263 type prosite sequence YTCHVQH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH source prosite : PS00290 18) chain B residue 19 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 19) chain B residue 41 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 20) chain B residue 48 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 58 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 22) chain B residue 91 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 94 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 2 type MOD_RES sequence Q description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 1 type CARBOHYD sequence I description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI2

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