eF-site ID 3btl-ABDE PDB Code 3btl Chain A, B, D, E click to enlarge Title crystal structure of QacR(E58Q) bound to malachite green Classification TRANSCRIPTION Compound HTH-type transcriptional regulator qacR Source Staphylococcus aureus (strain Mu50 / ATCC 700699) (QACR_STAAM) Sequence A:  NLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYY HFKTKENLFLEILNIEQSKWQEQWKKEQIKAKTNREKFYL YNELSLTTEYYYPLQNAIIEFYTEYYKTNSINEKMNKLEN KYIDAYHVIFKEGNLNGEWSINDVNAVSKIAANAVNGIVT FTHEQNINERIKLMNKFSQIFLNGLS B:  NLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYY HFKTKENLFLEILNIEQSKWQEQWKKEQIKAKTNREKFYL YNELSLTTEYYYPLQNAIIEFYTEYYKTNSINEKMNKLEN KYIDAYHVIFKEGNLNGEWSINDVNAVSKIAANAVNGIVT FTHEQNINERIKLMNKFSQIFLNGLS D:  NLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYY HFKTKENLFLEILNIEQSKWQEQWKKEQIKAKTNREKFYL YNELSLTTEYYYPLQNAIIEFYTEYYKTNSINEKMNKLEN KYIDAYHVIFKEGNLNGEWSINDVNAVSKIAANAVNGIVT FTHEQNINERIKLMNKFSQIFLNGLS E:  NLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYY HFKTKENLFLEILNIEQSKWQEQWKKEQIKAKTNREKFYL YNELSLTTEYYYPLQNAIIEFYTEYYKTNSINEKMNKLEN KYIDAYHVIFKEGNLNGEWSINDVNAVSKIAANAVNGIVT FTHEQNINERIKLMNKFSQIFLNGLS Description Functional site 1) chain A residue 4 type sequence K description BINDING SITE FOR RESIDUE SO4 A 299 source : AC1 2) chain A residue 42 type sequence H description BINDING SITE FOR RESIDUE SO4 A 299 source : AC1 3) chain E residue 24 type sequence T description BINDING SITE FOR RESIDUE SO4 E 900 source : AC2 4) chain E residue 25 type sequence T description BINDING SITE FOR RESIDUE SO4 E 900 source : AC2 5) chain E residue 26 type sequence G description BINDING SITE FOR RESIDUE SO4 E 900 source : AC2 6) chain E residue 36 type sequence K description BINDING SITE FOR RESIDUE SO4 E 900 source : AC2 7) chain D residue 24 type sequence T description BINDING SITE FOR RESIDUE SO4 D 270 source : AC3 8) chain D residue 26 type sequence G description BINDING SITE FOR RESIDUE SO4 D 270 source : AC3 9) chain D residue 27 type sequence E description BINDING SITE FOR RESIDUE SO4 D 270 source : AC3 10) chain D residue 36 type sequence K description BINDING SITE FOR RESIDUE SO4 D 270 source : AC3 11) chain E residue 36 type sequence K description BINDING SITE FOR RESIDUE SO4 E 249 source : AC4 12) chain E residue 40 type sequence Y description BINDING SITE FOR RESIDUE SO4 E 249 source : AC4 13) chain E residue 45 type sequence T description BINDING SITE FOR RESIDUE SO4 E 249 source : AC4 14) chain E residue 46 type sequence K description BINDING SITE FOR RESIDUE SO4 E 249 source : AC4 15) chain A residue 35 type sequence S description BINDING SITE FOR RESIDUE SO4 A 699 source : AC5 16) chain A residue 36 type sequence K description BINDING SITE FOR RESIDUE SO4 A 699 source : AC5 17) chain A residue 37 type sequence G description BINDING SITE FOR RESIDUE SO4 A 699 source : AC5 18) chain E residue 60 type sequence K description BINDING SITE FOR RESIDUE SO4 A 699 source : AC5 19) chain D residue 20 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 999 source : AC6 20) chain D residue 46 type sequence K description BINDING SITE FOR RESIDUE SO4 D 999 source : AC6 21) chain D residue 105 type sequence E description BINDING SITE FOR RESIDUE SO4 D 999 source : AC6 22) chain D residue 106 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 999 source : AC6 23) chain E residue 12 type sequence K description BINDING SITE FOR RESIDUE SO4 E 399 source : AC7 24) chain E residue 53 type sequence I description BINDING SITE FOR RESIDUE SO4 E 399 source : AC7 25) chain E residue 56 type sequence I description BINDING SITE FOR RESIDUE SO4 E 399 source : AC7 26) chain E residue 57 type sequence E description BINDING SITE FOR RESIDUE SO4 E 399 source : AC7 27) chain A residue 36 type sequence K description BINDING SITE FOR RESIDUE SO4 E 799 source : AC8 28) chain A residue 40 type sequence Y description BINDING SITE FOR RESIDUE SO4 E 799 source : AC8 29) chain E residue 2 type sequence N description BINDING SITE FOR RESIDUE SO4 E 799 source : AC8 30) chain E residue 5 type sequence D description BINDING SITE FOR RESIDUE SO4 E 799 source : AC8 31) chain E residue 6 type sequence K description BINDING SITE FOR RESIDUE SO4 E 799 source : AC8 32) chain A residue 128 type sequence H description BINDING SITE FOR RESIDUE SO4 A 801 source : AC9 33) chain A residue 132 type sequence K description BINDING SITE FOR RESIDUE SO4 A 801 source : AC9 34) chain A residue 2 type sequence N description BINDING SITE FOR RESIDUE SO4 A 279 source : BC1 35) chain A residue 3 type sequence L description BINDING SITE FOR RESIDUE SO4 A 279 source : BC1 36) chain A residue 4 type sequence K description BINDING SITE FOR RESIDUE SO4 A 279 source : BC1 37) chain A residue 42 type sequence H description BINDING SITE FOR RESIDUE SO4 A 279 source : BC1 38) chain E residue 128 type sequence H description BINDING SITE FOR RESIDUE SO4 E 239 source : BC2 39) chain E residue 132 type sequence K description BINDING SITE FOR RESIDUE SO4 E 239 source : BC2 40) chain D residue 13 type sequence E description BINDING SITE FOR RESIDUE SO4 D 779 source : BC3 41) chain D residue 16 type sequence I description BINDING SITE FOR RESIDUE SO4 D 779 source : BC3 42) chain D residue 17 type sequence K description BINDING SITE FOR RESIDUE SO4 D 779 source : BC3 43) chain D residue 30 type sequence K description BINDING SITE FOR RESIDUE SO4 D 779 source : BC3 44) chain A residue 57 type sequence E description BINDING SITE FOR RESIDUE SO4 A 431 source : BC4 45) chain A residue 61 type sequence W description BINDING SITE FOR RESIDUE SO4 A 431 source : BC4 46) chain A residue 64 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 431 source : BC4 47) chain A residue 93 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 431 source : BC4 48) chain D residue 23 type sequence T description BINDING SITE FOR RESIDUE SO4 D 432 source : BC5 49) chain D residue 24 type sequence T description BINDING SITE FOR RESIDUE SO4 D 432 source : BC5 50) chain D residue 25 type sequence T description BINDING SITE FOR RESIDUE SO4 D 432 source : BC5 51) chain D residue 46 type sequence K description BINDING SITE FOR RESIDUE SO4 D 432 source : BC5 52) chain A residue 16 type sequence I description BINDING SITE FOR RESIDUE SO4 A 433 source : BC6 53) chain A residue 17 type sequence K description BINDING SITE FOR RESIDUE SO4 A 433 source : BC6 54) chain A residue 94 type sequence P description BINDING SITE FOR RESIDUE SO4 A 433 source : BC6 55) chain A residue 97 type sequence N description BINDING SITE FOR RESIDUE SO4 A 433 source : BC6 56) chain D residue 16 type sequence I description BINDING SITE FOR RESIDUE SO4 D 434 source : BC7 57) chain A residue 61 type sequence W description BINDING SITE FOR RESIDUE MGR A 200 source : BC8 58) chain A residue 90 type sequence E description BINDING SITE FOR RESIDUE MGR A 200 source : BC8 59) chain A residue 103 type sequence Y description BINDING SITE FOR RESIDUE MGR A 200 source : BC8 60) chain A residue 120 type sequence E description BINDING SITE FOR RESIDUE MGR A 200 source : BC8 61) chain A residue 124 type sequence I description BINDING SITE FOR RESIDUE MGR A 200 source : BC8 62) chain A residue 153 type sequence A description BINDING SITE FOR RESIDUE MGR A 200 source : BC8 63) chain A residue 154 type sequence N description BINDING SITE FOR RESIDUE MGR A 200 source : BC8 64) chain A residue 157 type sequence N description BINDING SITE FOR RESIDUE MGR A 200 source : BC8 65) chain B residue 19-49 type prosite sequence GYNATTTGEIVKLSESSKGNLYYHFKTKENL description HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L source prosite : PS01081 66) chain B residue 24-43 type DNA_BIND sequence TTGEIVKLSESSKGNLYYHF description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335 source Swiss-Prot : SWS_FT_FI1 67) chain D residue 24-43 type DNA_BIND sequence TTGEIVKLSESSKGNLYYHF description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335 source Swiss-Prot : SWS_FT_FI1 68) chain A residue 24-43 type DNA_BIND sequence TTGEIVKLSESSKGNLYYHF description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335 source Swiss-Prot : SWS_FT_FI1 69) chain E residue 24-43 type DNA_BIND sequence TTGEIVKLSESSKGNLYYHF description H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335 source Swiss-Prot : SWS_FT_FI1

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