eF-site ID 3blw-D PDB Code 3blw Chain D click to enlarge Title Yeast Isocitrate Dehydrogenase with Citrate and AMP Bound in the Regulatory Subunits Classification OXIDOREDUCTASE Compound Isocitrate dehydrogenase [NAD] subunit 1 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (IDH2_YEAST) Sequence D:  KQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKI FSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITKNLVA LKGPLATPHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYE NVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASER VIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKEL SKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYG DILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDI AGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIA SGPENRTGDLAGTATTSSFTEAVIKRL Description Functional site 1) chain D residue 189 type sequence K description BINDING SITE FOR RESIDUE FLC C 1002 source : AC2 2) chain D residue 223 type sequence N description BINDING SITE FOR RESIDUE AMP C 2002 source : BC1 3) chain D residue 142 type SITE sequence Y description Critical for catalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 4) chain D residue 189 type SITE sequence K description Critical for catalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 5) chain D residue 90 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI4 6) chain D residue 248 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P50213 source Swiss-Prot : SWS_FT_FI2 7) chain D residue 252 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P50213 source Swiss-Prot : SWS_FT_FI2 8) chain D residue 104 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 9) chain D residue 114 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 10) chain D residue 135 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 11) chain D residue 222 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain D residue 138 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI5 13) chain D residue 312 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI6 14) chain D residue 334 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:17761666 source Swiss-Prot : SWS_FT_FI7

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