eF-site ID 3blr-AB PDB Code 3blr Chain A, B click to enlarge Title Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol Classification TRANSCRIPTION Compound Cell division protein kinase 9 Source null (CCNT1_HUMAN) Sequence A:  SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVA LKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICR TSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL APNRYXNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMA EMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYE LYEKLELVKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID SDDALNHDFFWSDPMPSDLKG B:  NKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDM GQRLNVSQLTINTAIVYMHRFYMIQSFTRFPGNSVAPAAL FLAAKVEGQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQ QVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASK DLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWS NWEIPVSTDGKHWWEYVDATVTLELLDELTHELLQILEKT PNRLKRIWNWR Description Functional site 1) chain B residue 99 type sequence K description BINDING SITE FOR RESIDUE PO4 B 260 source : AC1 2) chain B residue 100 type sequence K description BINDING SITE FOR RESIDUE PO4 B 260 source : AC1 3) chain B residue 103 type sequence H description BINDING SITE FOR RESIDUE PO4 B 260 source : AC1 4) chain A residue 141 type sequence H description BINDING SITE FOR RESIDUE PO4 A 331 source : AC2 5) chain A residue 305 type sequence D description BINDING SITE FOR RESIDUE PO4 A 331 source : AC2 6) chain A residue 306 type sequence S description BINDING SITE FOR RESIDUE PO4 A 331 source : AC2 7) chain A residue 307 type sequence D description BINDING SITE FOR RESIDUE PO4 A 331 source : AC2 8) chain B residue 250 type sequence N description BINDING SITE FOR RESIDUE PO4 B 261 source : AC3 9) chain B residue 254 type sequence R description BINDING SITE FOR RESIDUE PO4 B 261 source : AC3 10) chain A residue 25 type sequence I description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 11) chain A residue 30 type sequence F description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 12) chain A residue 46 type sequence A description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 13) chain A residue 48 type sequence K description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 14) chain A residue 103 type sequence F description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 15) chain A residue 106 type sequence C description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 16) chain A residue 107 type sequence E description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 17) chain A residue 153 type sequence A description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 18) chain A residue 154 type sequence N description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 19) chain A residue 156 type sequence L description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 20) chain A residue 167 type sequence D description BINDING SITE FOR RESIDUE CPB A 940 source : AC4 21) chain A residue 25 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 48 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 104 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 167 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 44 type MOD_RES sequence K description N6-acetyllysine; by EP300/CBP, PCAF/KAT2B and GCN5/KAT2A => ECO:0000269|PubMed:17452463, ECO:0000269|PubMed:18250157 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 175 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:21533037 source Swiss-Prot : SWS_FT_FI6 27) chain A residue 186 type MOD_RES sequence X description Phosphothreonine; by CaMK1D => ECO:0000269|PubMed:15965233, ECO:0000269|PubMed:18483222, ECO:0000269|PubMed:18566585, ECO:0000269|PubMed:18829461, ECO:0000269|PubMed:20535204, ECO:0000269|PubMed:20851342, ECO:0000269|PubMed:21448926, ECO:0000269|PubMed:21779453, ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI7 28) chain A residue 25-48 type prosite sequence IGQGTFGEVFKARHRKTGQKVALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGTFGEVFkArhrktgqk..........VALK source prosite : PS00107 29) chain A residue 145-157 type prosite sequence ILHRDMKAANVLI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDMKaaNVLI source prosite : PS00108 30) chain A residue 48 type MOD_RES sequence K description N6-acetyllysine; by PCAF/KAT2B and GCN5/KAT2A => ECO:0000269|PubMed:18250157, ECO:0000269|PubMed:28426094 source Swiss-Prot : SWS_FT_FI5 31) chain B residue 117 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI1

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