eF-site ID 3blr-A
PDB Code 3blr
Chain A

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Title Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol
Classification TRANSCRIPTION
Compound Cell division protein kinase 9
Source Homo sapiens (Human) (CCNT1_HUMAN)
Sequence A:  SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVA
LKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICR
TSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG
LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL
APNRYXNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMA
EMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYE
LYEKLELVKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID
SDDALNHDFFWSDPMPSDLKG
Description


Functional site

1) chain A
residue 141
type
sequence H
description BINDING SITE FOR RESIDUE PO4 A 331
source : AC2

2) chain A
residue 305
type
sequence D
description BINDING SITE FOR RESIDUE PO4 A 331
source : AC2

3) chain A
residue 306
type
sequence S
description BINDING SITE FOR RESIDUE PO4 A 331
source : AC2

4) chain A
residue 307
type
sequence D
description BINDING SITE FOR RESIDUE PO4 A 331
source : AC2

5) chain A
residue 25
type
sequence I
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

6) chain A
residue 30
type
sequence F
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

7) chain A
residue 46
type
sequence A
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

8) chain A
residue 48
type
sequence K
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

9) chain A
residue 103
type
sequence F
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

10) chain A
residue 106
type
sequence C
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

11) chain A
residue 107
type
sequence E
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

12) chain A
residue 153
type
sequence A
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

13) chain A
residue 154
type
sequence N
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

14) chain A
residue 156
type
sequence L
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

15) chain A
residue 167
type
sequence D
description BINDING SITE FOR RESIDUE CPB A 940
source : AC4

16) chain A
residue 25
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 48
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585
source Swiss-Prot : SWS_FT_FI3

18) chain A
residue 104
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585
source Swiss-Prot : SWS_FT_FI3

19) chain A
residue 167
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585
source Swiss-Prot : SWS_FT_FI3

20) chain A
residue 175
type MOD_RES
sequence S
description Phosphoserine => ECO:0000269|PubMed:21533037
source Swiss-Prot : SWS_FT_FI6

21) chain A
residue 186
type MOD_RES
sequence X
description Phosphothreonine; by CaMK1D => ECO:0000269|PubMed:15965233, ECO:0000269|PubMed:18483222, ECO:0000269|PubMed:18566585, ECO:0000269|PubMed:18829461, ECO:0000269|PubMed:20535204, ECO:0000269|PubMed:20851342, ECO:0000269|PubMed:21448926, ECO:0000269|PubMed:21779453, ECO:0007744|PubMed:21406692
source Swiss-Prot : SWS_FT_FI7

22) chain A
residue 25-48
type prosite
sequence IGQGTFGEVFKARHRKTGQKVALK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGTFGEVFkArhrktgqk..........VALK
source prosite : PS00107

23) chain A
residue 145-157
type prosite
sequence ILHRDMKAANVLI
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDMKaaNVLI
source prosite : PS00108

24) chain A
residue 44
type MOD_RES
sequence K
description N6-acetyllysine; by EP300/CBP, PCAF/KAT2B and GCN5/KAT2A => ECO:0000269|PubMed:17452463, ECO:0000269|PubMed:18250157
source Swiss-Prot : SWS_FT_FI4

25) chain A
residue 48
type MOD_RES
sequence K
description N6-acetyllysine; by PCAF/KAT2B and GCN5/KAT2A => ECO:0000269|PubMed:18250157, ECO:0000269|PubMed:28426094
source Swiss-Prot : SWS_FT_FI5


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