eF-site ID 3blq-AB PDB Code 3blq Chain A, B click to enlarge Title Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP Classification TRANSCRIPTION Compound Cell division protein kinase 9 Source null (CCNT1_HUMAN) Sequence A:  SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVA LKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICR TSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSN RYXNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYE KLELVVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA LNHDFFWSDPMPSDLK B:  NKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDM GQRLNVSQLTINTAIVYMHRFYMIQSFTRFPGNSVAPAAL FLAAKVEGQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQ QVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASK DLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWS NWEIPVSTDGKHWWEYVDATVTLELLDELTHELLQILEKT PNRLKRIWNWR Description Functional site 1) chain A residue 154 type sequence N description BINDING SITE FOR RESIDUE MG A 331 source : AC1 2) chain A residue 167 type sequence D description BINDING SITE FOR RESIDUE MG A 331 source : AC1 3) chain A residue 27 type sequence Q description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 4) chain A residue 46 type sequence A description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 5) chain A residue 48 type sequence K description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 6) chain A residue 103 type sequence F description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 7) chain A residue 104 type sequence D description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 8) chain A residue 106 type sequence C description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 9) chain A residue 149 type sequence D description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 10) chain A residue 151 type sequence K description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 11) chain A residue 154 type sequence N description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 12) chain A residue 167 type sequence D description BINDING SITE FOR RESIDUE ATP A 332 source : AC2 13) chain B residue 46 type sequence Q description BINDING SITE FOR RESIDUE TRS B 260 source : AC3 14) chain B residue 56 type sequence Q description BINDING SITE FOR RESIDUE TRS B 260 source : AC3 15) chain B residue 179 type sequence T description BINDING SITE FOR RESIDUE TRS B 260 source : AC3 16) chain B residue 254 type sequence R description BINDING SITE FOR RESIDUE TRS B 260 source : AC3 17) chain B residue 117 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 25 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 48 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 104 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 167 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18566585 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 44 type MOD_RES sequence K description N6-acetyllysine; by EP300/CBP, PCAF/KAT2B and GCN5/KAT2A => ECO:0000269|PubMed:17452463, ECO:0000269|PubMed:18250157 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 175 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:21533037 source Swiss-Prot : SWS_FT_FI6 24) chain A residue 25-48 type prosite sequence IGQGTFGEVFKARHRKTGQKVALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGTFGEVFkArhrktgqk..........VALK source prosite : PS00107 25) chain A residue 145-157 type prosite sequence ILHRDMKAANVLI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDMKaaNVLI source prosite : PS00108 26) chain A residue 48 type MOD_RES sequence K description N6-acetyllysine; by PCAF/KAT2B and GCN5/KAT2A => ECO:0000269|PubMed:18250157, ECO:0000269|PubMed:28426094 source Swiss-Prot : SWS_FT_FI5 27) chain A residue 186 type MOD_RES sequence X description Phosphothreonine; by CaMK1D => ECO:0000269|PubMed:15965233, ECO:0000269|PubMed:18483222, ECO:0000269|PubMed:18566585, ECO:0000269|PubMed:18829461, ECO:0000269|PubMed:20535204, ECO:0000269|PubMed:20851342, ECO:0000269|PubMed:21448926, ECO:0000269|PubMed:21779453, ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI7

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