|
|
eF-site ID
|
3bef-B |
|
PDB Code
|
3bef |
|
Chain
|
B |
|
click to enlarge
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|
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Title
|
Crystal structure of thrombin bound to the extracellular fragment of PAR1 |
|
Classification
|
HYDROLASE |
|
Compound
|
Prothrombin |
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Source
|
(PAR1_HUMAN) |
|
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Sequence
|
B: |
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRNIALMKLKKPVAFSDYIHPVCL
PDRETAASLLQAGYKGRVTGWGNLKETKGQPSVLQVVNLP
IVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRL
KKWIQKVIDQF
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
53-58 |
| type |
prosite |
| sequence |
LTAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
|
| source |
prosite : PS00134
|
|
|
2)
|
chain |
B |
| residue |
189-200 |
| type |
prosite |
| sequence |
DACEGDSGGPFV
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
|
| source |
prosite : PS00135
|
|
|
3)
|
chain |
B |
| residue |
195 |
| type |
SITE |
| sequence |
S
|
| description |
Cleavage; by CTSG => ECO:0000269|PubMed:7744748
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
60 |
| type |
CARBOHYD |
| sequence |
L
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|