eF-site ID 3bbb-ABCDEF PDB Code 3bbb Chain A, B, C, D, E, F click to enlarge Title Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG) Classification TRANSFERASE Compound Nucleoside diphosphate kinase B Source Homo sapiens (Human) (NDKB_HUMAN) Sequence A:  ANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFL RASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGL NVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSD SVKSAEKEISLWFKPEELVDYKSCAHDWVYE B:  ANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFL RASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGL NVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSD SVKSAEKEISLWFKPEELVDYKSCAHDWVYE C:  ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRAS EEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVK SAEKEISLWFKPEELVDYKSCAHDWVYE D:  ANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFL RASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGL NVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSD SVKSAEKEISLWFKPEELVDYKSCAHDWVYE E:  ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRAS EEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVV KTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVK SAEKEISLWFKPEELVDYKSCAHDWVYE F:  ANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFL RASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGL NVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSD SVKSAEKEISLWFKPEELVDYKSCAHDWVYE Description Functional site 1) chain C residue 12 type sequence K description BINDING SITE FOR RESIDUE DA C 153 source : AC1 2) chain C residue 52 type sequence Y description BINDING SITE FOR RESIDUE DA C 153 source : AC1 3) chain C residue 64 type sequence L description BINDING SITE FOR RESIDUE DA C 153 source : AC1 4) chain C residue 112 type sequence V description BINDING SITE FOR RESIDUE DA C 153 source : AC1 5) chain C residue 113 type sequence G description BINDING SITE FOR RESIDUE DA C 153 source : AC1 6) chain C residue 115 type sequence N description BINDING SITE FOR RESIDUE DA C 153 source : AC1 7) chain C residue 12 type sequence K description BINDING SITE FOR RESIDUE DG C 154 source : AC2 8) chain C residue 55 type sequence L description BINDING SITE FOR RESIDUE DG C 154 source : AC2 9) chain C residue 60 type sequence F description BINDING SITE FOR RESIDUE DG C 154 source : AC2 10) chain C residue 64 type sequence L description BINDING SITE FOR RESIDUE DG C 154 source : AC2 11) chain C residue 94 type sequence T description BINDING SITE FOR RESIDUE DG C 154 source : AC2 12) chain C residue 118 type sequence H description BINDING SITE FOR RESIDUE DG C 154 source : AC2 13) chain E residue 12 type sequence K description BINDING SITE FOR RESIDUE DA E 153 source : AC3 14) chain E residue 52 type sequence Y description BINDING SITE FOR RESIDUE DA E 153 source : AC3 15) chain E residue 64 type sequence L description BINDING SITE FOR RESIDUE DA E 153 source : AC3 16) chain E residue 112 type sequence V description BINDING SITE FOR RESIDUE DA E 153 source : AC3 17) chain E residue 60 type sequence F description BINDING SITE FOR RESIDUE DG E 154 source : AC4 18) chain E residue 94 type sequence T description BINDING SITE FOR RESIDUE DG E 154 source : AC4 19) chain E residue 115 type sequence N description BINDING SITE FOR RESIDUE DG E 154 source : AC4 20) chain B residue 58 type sequence R description BINDING SITE FOR RESIDUE DG B 153 source : AC5 21) chain B residue 60 type sequence F description BINDING SITE FOR RESIDUE DG B 153 source : AC5 22) chain B residue 64 type sequence L description BINDING SITE FOR RESIDUE DG B 153 source : AC5 23) chain B residue 94 type sequence T description BINDING SITE FOR RESIDUE DG B 153 source : AC5 24) chain B residue 113 type sequence G description BINDING SITE FOR RESIDUE DG B 153 source : AC5 25) chain E residue 122 type sequence S description BINDING SITE FOR RESIDUE DG B 153 source : AC5 26) chain E residue 123 type sequence V description BINDING SITE FOR RESIDUE DG B 153 source : AC5 27) chain E residue 152 type sequence E description BINDING SITE FOR RESIDUE DG F 153 source : AC6 28) chain F residue 12 type sequence K description BINDING SITE FOR RESIDUE DG F 153 source : AC6 29) chain F residue 52 type sequence Y description BINDING SITE FOR RESIDUE DG F 153 source : AC6 30) chain F residue 55 type sequence L description BINDING SITE FOR RESIDUE DG F 153 source : AC6 31) chain F residue 60 type sequence F description BINDING SITE FOR RESIDUE DG F 153 source : AC6 32) chain F residue 64 type sequence L description BINDING SITE FOR RESIDUE DG F 153 source : AC6 33) chain F residue 112 type sequence V description BINDING SITE FOR RESIDUE DG F 153 source : AC6 34) chain F residue 113 type sequence G description BINDING SITE FOR RESIDUE DG F 153 source : AC6 35) chain A residue 118 type ACT_SITE sequence H description Pros-phosphohistidine intermediate => ECO:0000269|PubMed:1851158 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 118 type ACT_SITE sequence H description Pros-phosphohistidine intermediate => ECO:0000269|PubMed:1851158 source Swiss-Prot : SWS_FT_FI1 37) chain C residue 118 type ACT_SITE sequence H description Pros-phosphohistidine intermediate => ECO:0000269|PubMed:1851158 source Swiss-Prot : SWS_FT_FI1 38) chain D residue 118 type ACT_SITE sequence H description Pros-phosphohistidine intermediate => ECO:0000269|PubMed:1851158 source Swiss-Prot : SWS_FT_FI1 39) chain E residue 118 type ACT_SITE sequence H description Pros-phosphohistidine intermediate => ECO:0000269|PubMed:1851158 source Swiss-Prot : SWS_FT_FI1 40) chain F residue 118 type ACT_SITE sequence H description Pros-phosphohistidine intermediate => ECO:0000269|PubMed:1851158 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 12 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 42) chain B residue 94 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 43) chain B residue 105 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 44) chain B residue 115 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 45) chain C residue 12 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 46) chain C residue 60 type BINDING sequence F description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 47) chain C residue 88 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 48) chain C residue 94 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 49) chain C residue 105 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 50) chain C residue 115 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 51) chain D residue 12 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 52) chain A residue 60 type BINDING sequence F description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 53) chain D residue 60 type BINDING sequence F description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 54) chain D residue 88 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 55) chain D residue 94 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 56) chain D residue 105 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 57) chain D residue 115 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 58) chain E residue 12 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 59) chain E residue 60 type BINDING sequence F description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 60) chain E residue 88 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 61) chain E residue 94 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 62) chain E residue 105 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 63) chain A residue 88 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 64) chain E residue 115 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 65) chain F residue 12 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 66) chain F residue 60 type BINDING sequence F description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 67) chain F residue 88 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 68) chain F residue 94 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 69) chain F residue 105 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 70) chain F residue 115 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 71) chain A residue 94 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 72) chain A residue 105 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 73) chain A residue 115 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 74) chain B residue 12 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 75) chain B residue 60 type BINDING sequence F description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 76) chain B residue 88 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19435876, ECO:0007744|PDB:3BBF source Swiss-Prot : SWS_FT_FI2 77) chain A residue 115-123 type prosite sequence NIIHGSDSV description NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NiiHGSDSV source prosite : PS00469

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