eF-site ID 3b8z-B PDB Code 3b8z Chain B click to enlarge Title High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2) Classification HYDROLASE Compound protein ADAMTS-5 Source Homo sapiens (Human) (ATS5_HUMAN) Sequence B:  SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYS HASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCK WQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMAD VGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS KFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF LDDGHGNCLLDLPRKQI Description Functional site 1) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC5 2) chain B residue 414 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC5 3) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC5 4) chain B residue 270 type sequence E description BINDING SITE FOR RESIDUE CA B 902 source : AC6 5) chain B residue 353 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC6 6) chain B residue 360 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC6 7) chain B residue 471 type sequence C description BINDING SITE FOR RESIDUE CA B 902 source : AC6 8) chain B residue 474 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC6 9) chain B residue 270 type sequence E description BINDING SITE FOR RESIDUE CA B 903 source : AC7 10) chain B residue 353 type sequence D description BINDING SITE FOR RESIDUE CA B 903 source : AC7 11) chain B residue 474 type sequence D description BINDING SITE FOR RESIDUE CA B 903 source : AC7 12) chain B residue 369 type sequence D description BINDING SITE FOR RESIDUE CA B 904 source : AC8 13) chain B residue 370 type sequence L description BINDING SITE FOR RESIDUE CA B 904 source : AC8 14) chain B residue 376 type sequence C description BINDING SITE FOR RESIDUE CA B 904 source : AC8 15) chain B residue 378 type sequence T description BINDING SITE FOR RESIDUE CA B 904 source : AC8 16) chain B residue 398 type sequence E description BINDING SITE FOR RESIDUE CA B 904 source : AC8 17) chain B residue 378 type sequence T description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 18) chain B residue 379 type sequence L description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 19) chain B residue 380 type sequence G description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 20) chain B residue 403 type sequence H description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 21) chain B residue 406 type sequence F description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 22) chain B residue 407 type sequence T description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 23) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 24) chain B residue 411 type sequence E description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 25) chain B residue 414 type sequence H description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 26) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 27) chain B residue 438 type sequence L description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 28) chain B residue 441 type sequence S description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 29) chain B residue 443 type sequence L description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 30) chain B residue 444 type sequence T description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 31) chain B residue 446 type sequence I description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 32) chain B residue 410 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 414 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 420 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 411 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1

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