eF-site ID 3b8z-AB PDB Code 3b8z Chain A, B click to enlarge Title High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2) Classification HYDROLASE Compound protein ADAMTS-5 Source null (ATS5_HUMAN) Sequence A:  SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYS HASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCK WQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMAD VGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS KFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF LDDGHGNCLLDLPRKQI B:  SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYS HASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCK WQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMAD VGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS KFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF LDDGHGNCLLDLPRKQI Description Functional site 1) chain A residue 410 type sequence H description BINDING SITE FOR RESIDUE ZN A 901 source : AC1 2) chain A residue 414 type sequence H description BINDING SITE FOR RESIDUE ZN A 901 source : AC1 3) chain A residue 420 type sequence H description BINDING SITE FOR RESIDUE ZN A 901 source : AC1 4) chain A residue 270 type sequence E description BINDING SITE FOR RESIDUE CA A 902 source : AC2 5) chain A residue 353 type sequence D description BINDING SITE FOR RESIDUE CA A 902 source : AC2 6) chain A residue 360 type sequence D description BINDING SITE FOR RESIDUE CA A 902 source : AC2 7) chain A residue 471 type sequence C description BINDING SITE FOR RESIDUE CA A 902 source : AC2 8) chain A residue 474 type sequence D description BINDING SITE FOR RESIDUE CA A 902 source : AC2 9) chain A residue 270 type sequence E description BINDING SITE FOR RESIDUE CA A 903 source : AC3 10) chain A residue 353 type sequence D description BINDING SITE FOR RESIDUE CA A 903 source : AC3 11) chain A residue 474 type sequence D description BINDING SITE FOR RESIDUE CA A 903 source : AC3 12) chain A residue 369 type sequence D description BINDING SITE FOR RESIDUE CA A 904 source : AC4 13) chain A residue 370 type sequence L description BINDING SITE FOR RESIDUE CA A 904 source : AC4 14) chain A residue 376 type sequence C description BINDING SITE FOR RESIDUE CA A 904 source : AC4 15) chain A residue 378 type sequence T description BINDING SITE FOR RESIDUE CA A 904 source : AC4 16) chain A residue 398 type sequence E description BINDING SITE FOR RESIDUE CA A 904 source : AC4 17) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC5 18) chain B residue 414 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC5 19) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE ZN B 901 source : AC5 20) chain B residue 270 type sequence E description BINDING SITE FOR RESIDUE CA B 902 source : AC6 21) chain B residue 353 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC6 22) chain B residue 360 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC6 23) chain B residue 471 type sequence C description BINDING SITE FOR RESIDUE CA B 902 source : AC6 24) chain B residue 474 type sequence D description BINDING SITE FOR RESIDUE CA B 902 source : AC6 25) chain B residue 270 type sequence E description BINDING SITE FOR RESIDUE CA B 903 source : AC7 26) chain B residue 353 type sequence D description BINDING SITE FOR RESIDUE CA B 903 source : AC7 27) chain B residue 474 type sequence D description BINDING SITE FOR RESIDUE CA B 903 source : AC7 28) chain B residue 369 type sequence D description BINDING SITE FOR RESIDUE CA B 904 source : AC8 29) chain B residue 370 type sequence L description BINDING SITE FOR RESIDUE CA B 904 source : AC8 30) chain B residue 376 type sequence C description BINDING SITE FOR RESIDUE CA B 904 source : AC8 31) chain B residue 378 type sequence T description BINDING SITE FOR RESIDUE CA B 904 source : AC8 32) chain B residue 398 type sequence E description BINDING SITE FOR RESIDUE CA B 904 source : AC8 33) chain A residue 378 type sequence T description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 34) chain A residue 379 type sequence L description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 35) chain A residue 380 type sequence G description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 36) chain A residue 403 type sequence H description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 37) chain A residue 406 type sequence F description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 38) chain A residue 410 type sequence H description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 39) chain A residue 411 type sequence E description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 40) chain A residue 414 type sequence H description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 41) chain A residue 420 type sequence H description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 42) chain A residue 438 type sequence L description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 43) chain A residue 441 type sequence S description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 44) chain A residue 443 type sequence L description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 45) chain A residue 444 type sequence T description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 46) chain A residue 445 type sequence S description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 47) chain A residue 446 type sequence I description BINDING SITE FOR RESIDUE 294 A 801 source : AC9 48) chain B residue 378 type sequence T description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 49) chain B residue 379 type sequence L description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 50) chain B residue 380 type sequence G description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 51) chain B residue 403 type sequence H description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 52) chain B residue 406 type sequence F description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 53) chain B residue 407 type sequence T description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 54) chain B residue 410 type sequence H description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 55) chain B residue 411 type sequence E description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 56) chain B residue 414 type sequence H description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 57) chain B residue 420 type sequence H description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 58) chain B residue 438 type sequence L description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 59) chain B residue 441 type sequence S description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 60) chain B residue 443 type sequence L description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 61) chain B residue 444 type sequence T description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 62) chain B residue 446 type sequence I description BINDING SITE FOR RESIDUE 294 B 801 source : BC1 63) chain B residue 411 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 411 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 410 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 66) chain B residue 414 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 67) chain B residue 420 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 410 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 414 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 70) chain A residue 420 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 71) chain A residue 407-416 type prosite sequence TVAHEIGHLL description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL source prosite : PS00142

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