eF-site ID 3b7v-ABC PDB Code 3b7v Chain A, B, C click to enlarge Title HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI Classification HYDROLASE/HYDROLASE INHIBITOR Compound Protease Source null (3B7V) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF C:  NLXQI Description Functional site 1) chain A residue 60 type sequence D description BINDING SITE FOR RESIDUE NA A 901 source : AC1 2) chain A residue 74 type sequence T description BINDING SITE FOR RESIDUE CL A 902 source : AC2 3) chain A residue 88 type sequence N description BINDING SITE FOR RESIDUE CL A 902 source : AC2 4) chain B residue 141 type sequence R description BINDING SITE FOR RESIDUE CL A 902 source : AC2 5) chain B residue 106 type sequence W description BINDING SITE FOR RESIDUE CL B 903 source : AC3 6) chain B residue 174 type sequence T description BINDING SITE FOR RESIDUE CL B 904 source : AC4 7) chain B residue 188 type sequence N description BINDING SITE FOR RESIDUE CL B 904 source : AC4 8) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE GOL B 905 source : AC5 9) chain A residue 18 type sequence Q description BINDING SITE FOR RESIDUE GOL B 905 source : AC5 10) chain B residue 101 type sequence P description BINDING SITE FOR RESIDUE GOL B 905 source : AC5 11) chain B residue 167 type sequence A description BINDING SITE FOR RESIDUE GOL B 905 source : AC5 12) chain B residue 169 type sequence H description BINDING SITE FOR RESIDUE GOL B 905 source : AC5 13) chain A residue 8 type sequence R description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 14) chain A residue 25 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 15) chain A residue 27 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 16) chain A residue 28 type sequence A description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 17) chain A residue 29 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 18) chain A residue 30 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 19) chain A residue 32 type sequence V description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 20) chain A residue 47 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 21) chain A residue 48 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 22) chain A residue 49 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 23) chain A residue 50 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 24) chain A residue 82 type sequence V description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 25) chain A residue 84 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 26) chain B residue 108 type sequence R description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 27) chain B residue 123 type sequence L description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 28) chain B residue 125 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 29) chain B residue 127 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 30) chain B residue 128 type sequence A description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 31) chain B residue 129 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 32) chain B residue 130 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 33) chain B residue 147 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 34) chain B residue 148 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 35) chain B residue 149 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 36) chain B residue 150 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 37) chain B residue 153 type sequence F description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 38) chain B residue 181 type sequence P description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 39) chain B residue 182 type sequence V description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 40) chain B residue 184 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 41) chain B residue 125 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 199 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141

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