eF-site ID 3b7v-A PDB Code 3b7v Chain A click to enlarge Title HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI Classification HYDROLASE/HYDROLASE INHIBITOR Compound Protease Source Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1) (3B7V) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF Description Functional site 1) chain A residue 60 type sequence D description BINDING SITE FOR RESIDUE NA A 901 source : AC1 2) chain A residue 74 type sequence T description BINDING SITE FOR RESIDUE CL A 902 source : AC2 3) chain A residue 88 type sequence N description BINDING SITE FOR RESIDUE CL A 902 source : AC2 4) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE GOL B 905 source : AC5 5) chain A residue 18 type sequence Q description BINDING SITE FOR RESIDUE GOL B 905 source : AC5 6) chain A residue 8 type sequence R description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 7) chain A residue 25 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 8) chain A residue 27 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 9) chain A residue 28 type sequence A description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 10) chain A residue 29 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 11) chain A residue 30 type sequence D description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 12) chain A residue 32 type sequence V description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 13) chain A residue 47 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 14) chain A residue 48 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 15) chain A residue 49 type sequence G description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 16) chain A residue 50 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 17) chain A residue 82 type sequence V description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 18) chain A residue 84 type sequence I description BINDING SITE FOR CHAIN C OF PEPTIDE source : AC6 19) chain A residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141

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