eF-site ID 3b35-A
PDB Code 3b35
Chain A

click to enlarge
Title Crystal structure of the M180A mutant of the aminopeptidase from Vibrio proteolyticus
Classification HYDROLASE
Compound Bacterial leucyl aminopeptidase
Source Vibrio proteolyticus (Aeromonas proteolytica) (AMPX_VIBPR)
Sequence A:  MPPITQQATVTAWLPQVDASQITGTISSLESFTNRFYTTT
SGAQASDWIASEWQALSASLPNASVKQVSHSGYNQKSVVM
TITGSEAPDEWIVIGGHLDSTIGSHTNEQSVAPGADDDAS
GIAAVTEVIRVLSENNFQPKRSIAFMAYAAEEVGLRGSQD
LANQYKSEGKNVVSALQLDATNYKGSAQDVVFITDYTDSN
FTQYLTQLMDEYLPSLTYGFDTCGYACSDHASWHNAGYPA
AMPFESKFNDYNPRIHTTQDTLANSDPTGSHAKKFTQLGL
AYAIEMGSATG
Description


Functional site
1) chain A
residue 117
type
sequence D
description BINDING SITE FOR RESIDUE ZN A 292
source : AC1
2) chain A
residue 152
type
sequence E
description BINDING SITE FOR RESIDUE ZN A 292
source : AC1
3) chain A
residue 256
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 292
source : AC1
4) chain A
residue 97
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 293
source : AC2
5) chain A
residue 117
type
sequence D
description BINDING SITE FOR RESIDUE ZN A 293
source : AC2
6) chain A
residue 151
type
sequence E
description BINDING SITE FOR RESIDUE ZN A 293
source : AC2
7) chain A
residue 179
type
sequence D
description BINDING SITE FOR RESIDUE ZN A 293
source : AC2
8) chain A
residue 6
type
sequence Q
description BINDING SITE FOR RESIDUE NA A 294
source : AC3
9) chain A
residue 9
type
sequence T
description BINDING SITE FOR RESIDUE NA A 294
source : AC3
10) chain A
residue 24
type
sequence G
description BINDING SITE FOR RESIDUE NA A 295
source : AC4
11) chain A
residue 27
type
sequence S
description BINDING SITE FOR RESIDUE NA A 295
source : AC4
12) chain A
residue 28
type
sequence S
description BINDING SITE FOR RESIDUE NA A 295
source : AC4
13) chain A
residue 200
type
sequence N
description BINDING SITE FOR RESIDUE NA A 295
source : AC4
14) chain A
residue 38
type
sequence T
description BINDING SITE FOR RESIDUE NA A 296
source : AC5
15) chain A
residue 73
type
sequence Y
description BINDING SITE FOR RESIDUE NA A 296
source : AC5
16) chain A
residue 74
type
sequence N
description BINDING SITE FOR RESIDUE NA A 296
source : AC5
17) chain A
residue 72
type
sequence G
description BINDING SITE FOR RESIDUE NA A 297
source : AC6
18) chain A
residue 257
type
sequence T
description BINDING SITE FOR RESIDUE NA A 298
source : AC7
19) chain A
residue 258
type
sequence T
description BINDING SITE FOR RESIDUE NA A 298
source : AC7
20) chain A
residue 258
type
sequence T
description BINDING SITE FOR RESIDUE NA A 298
source : AC7
21) chain A
residue 259
type
sequence Q
description BINDING SITE FOR RESIDUE NA A 298
source : AC7
22) chain A
residue 213
type
sequence L
description BINDING SITE FOR RESIDUE NA A 299
source : AC8
23) chain A
residue 214
type
sequence P
description BINDING SITE FOR RESIDUE NA A 299
source : AC8
24) chain A
residue 215
type
sequence S
description BINDING SITE FOR RESIDUE NA A 299
source : AC8
25) chain A
residue 19
type
sequence A
description BINDING SITE FOR RESIDUE NA A 300
source : AC9
26) chain A
residue 273
type
sequence K
description BINDING SITE FOR RESIDUE NA A 300
source : AC9
27) chain A
residue 194
type
sequence T
description BINDING SITE FOR RESIDUE SCN A 301
source : BC1
28) chain A
residue 199
type
sequence S
description BINDING SITE FOR RESIDUE SCN A 301
source : BC1
29) chain A
residue 202
type
sequence T
description BINDING SITE FOR RESIDUE SCN A 301
source : BC1
30) chain A
residue 203
type
sequence Q
description BINDING SITE FOR RESIDUE SCN A 301
source : BC1
31) chain A
residue 262
type
sequence L
description BINDING SITE FOR RESIDUE SCN A 301
source : BC1
32) chain A
residue 7
type
sequence Q
description BINDING SITE FOR RESIDUE SCN A 302
source : BC2
33) chain A
residue 12
type
sequence A
description BINDING SITE FOR RESIDUE SCN A 302
source : BC2
34) chain A
residue 13
type
sequence W
description BINDING SITE FOR RESIDUE SCN A 302
source : BC2
35) chain A
residue 16
type
sequence Q
description BINDING SITE FOR RESIDUE SCN A 302
source : BC2
36) chain A
residue 97
type catalytic
sequence H
description 167
source MCSA : MCSA1
37) chain A
residue 117
type catalytic
sequence D
description 167
source MCSA : MCSA1
38) chain A
residue 151
type catalytic
sequence E
description 167
source MCSA : MCSA1
39) chain A
residue 152
type catalytic
sequence E
description 167
source MCSA : MCSA1
40) chain A
residue 179
type catalytic
sequence D
description 167
source MCSA : MCSA1
41) chain A
residue 256
type catalytic
sequence H
description 167
source MCSA : MCSA1
42) chain A
residue 97
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10413478, ECO:0000269|PubMed:11401547, ECO:0000269|PubMed:8087555, ECO:0000269|PubMed:8647077, ECO:0007744|PDB:1AMP, ECO:0007744|PDB:1CP6, ECO:0007744|PDB:1FT7, ECO:0007744|PDB:1IGB, ECO:0007744|PDB:1LOK, ECO:0007744|PDB:1RTQ, ECO:0007744|PDB:1TXR, ECO:0007744|PDB:1XRY, ECO:0007744|PDB:2ANP, ECO:0007744|PDB:2DEA, ECO:0007744|PDB:2IQ6, ECO:0007744|PDB:2NYQ, ECO:0007744|PDB:3B35, ECO:0007744|PDB:3B3C, ECO:0007744|PDB:3B3S, ECO:0007744|PDB:3B3T, ECO:0007744|PDB:3B3V, ECO:0007744|PDB:3B3W, ECO:0007744|PDB:3B7I, ECO:0007744|PDB:3FH4, ECO:0007744|PDB:3VH9
source Swiss-Prot : SWS_FT_FI1
43) chain A
residue 117
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10413478, ECO:0000269|PubMed:11401547, ECO:0000269|PubMed:8087555, ECO:0000269|PubMed:8647077, ECO:0007744|PDB:1AMP, ECO:0007744|PDB:1CP6, ECO:0007744|PDB:1FT7, ECO:0007744|PDB:1IGB, ECO:0007744|PDB:1LOK, ECO:0007744|PDB:1RTQ, ECO:0007744|PDB:1TXR, ECO:0007744|PDB:1XRY, ECO:0007744|PDB:2ANP, ECO:0007744|PDB:2DEA, ECO:0007744|PDB:2IQ6, ECO:0007744|PDB:2NYQ, ECO:0007744|PDB:3B35, ECO:0007744|PDB:3B3C, ECO:0007744|PDB:3B3S, ECO:0007744|PDB:3B3T, ECO:0007744|PDB:3B3V, ECO:0007744|PDB:3B3W, ECO:0007744|PDB:3B7I, ECO:0007744|PDB:3FH4, ECO:0007744|PDB:3VH9
source Swiss-Prot : SWS_FT_FI1
44) chain A
residue 152
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:10413478, ECO:0000269|PubMed:11401547, ECO:0000269|PubMed:8087555, ECO:0000269|PubMed:8647077, ECO:0007744|PDB:1AMP, ECO:0007744|PDB:1CP6, ECO:0007744|PDB:1FT7, ECO:0007744|PDB:1IGB, ECO:0007744|PDB:1LOK, ECO:0007744|PDB:1RTQ, ECO:0007744|PDB:1TXR, ECO:0007744|PDB:1XRY, ECO:0007744|PDB:2ANP, ECO:0007744|PDB:2DEA, ECO:0007744|PDB:2IQ6, ECO:0007744|PDB:2NYQ, ECO:0007744|PDB:3B35, ECO:0007744|PDB:3B3C, ECO:0007744|PDB:3B3S, ECO:0007744|PDB:3B3T, ECO:0007744|PDB:3B3V, ECO:0007744|PDB:3B3W, ECO:0007744|PDB:3B7I, ECO:0007744|PDB:3FH4, ECO:0007744|PDB:3VH9
source Swiss-Prot : SWS_FT_FI1
45) chain A
residue 179
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:10413478, ECO:0000269|PubMed:11401547, ECO:0000269|PubMed:8087555, ECO:0000269|PubMed:8647077, ECO:0007744|PDB:1AMP, ECO:0007744|PDB:1CP6, ECO:0007744|PDB:1FT7, ECO:0007744|PDB:1IGB, ECO:0007744|PDB:1LOK, ECO:0007744|PDB:1RTQ, ECO:0007744|PDB:1TXR, ECO:0007744|PDB:1XRY, ECO:0007744|PDB:2ANP, ECO:0007744|PDB:2DEA, ECO:0007744|PDB:2IQ6, ECO:0007744|PDB:2NYQ, ECO:0007744|PDB:3B35, ECO:0007744|PDB:3B3C, ECO:0007744|PDB:3B3S, ECO:0007744|PDB:3B3T, ECO:0007744|PDB:3B3V, ECO:0007744|PDB:3B3W, ECO:0007744|PDB:3B7I, ECO:0007744|PDB:3FH4, ECO:0007744|PDB:3VH9
source Swiss-Prot : SWS_FT_FI1
46) chain A
residue 256
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:10413478, ECO:0000269|PubMed:11401547, ECO:0000269|PubMed:8087555, ECO:0000269|PubMed:8647077, ECO:0007744|PDB:1AMP, ECO:0007744|PDB:1CP6, ECO:0007744|PDB:1FT7, ECO:0007744|PDB:1IGB, ECO:0007744|PDB:1LOK, ECO:0007744|PDB:1RTQ, ECO:0007744|PDB:1TXR, ECO:0007744|PDB:1XRY, ECO:0007744|PDB:2ANP, ECO:0007744|PDB:2DEA, ECO:0007744|PDB:2IQ6, ECO:0007744|PDB:2NYQ, ECO:0007744|PDB:3B35, ECO:0007744|PDB:3B3C, ECO:0007744|PDB:3B3S, ECO:0007744|PDB:3B3T, ECO:0007744|PDB:3B3V, ECO:0007744|PDB:3B3W, ECO:0007744|PDB:3B7I, ECO:0007744|PDB:3FH4, ECO:0007744|PDB:3VH9
source Swiss-Prot : SWS_FT_FI1

Display surface

Download
Links