eF-site ID 3b34-A PDB Code 3b34 Chain A click to enlarge Title Crystal structure of E. coli Aminopeptidase N in complex with Phenylalanine Classification HYDROLASE Compound Aminopeptidase N Source null (AMPN_ECOLI) Sequence A:  PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVR HGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVIS NLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEG FRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQ GELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTR SGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLE YDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTAT DKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTV FRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPI RPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGM QLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSG TPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIP FAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNV YFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSR WDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLL DEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREAL TRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNAC LRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQ LPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLET VRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSG YLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKM RAALEQLKGLENLSGDLYEKITKALA Description Functional site 1) chain A residue 297 type sequence H description BINDING SITE FOR RESIDUE ZN A 950 source : AC1 2) chain A residue 301 type sequence H description BINDING SITE FOR RESIDUE ZN A 950 source : AC1 3) chain A residue 320 type sequence E description BINDING SITE FOR RESIDUE ZN A 950 source : AC1 4) chain A residue 332 type sequence S description BINDING SITE FOR RESIDUE NA A 951 source : AC2 5) chain A residue 333 type sequence D description BINDING SITE FOR RESIDUE NA A 951 source : AC2 6) chain A residue 335 type sequence G description BINDING SITE FOR RESIDUE NA A 951 source : AC2 7) chain A residue 452 type sequence D description BINDING SITE FOR RESIDUE NA A 952 source : AC3 8) chain A residue 119 type sequence Q description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 9) chain A residue 121 type sequence E description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 10) chain A residue 260 type sequence M description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 11) chain A residue 262 type sequence A description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 12) chain A residue 263 type sequence M description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 13) chain A residue 264 type sequence E description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 14) chain A residue 297 type sequence H description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 15) chain A residue 298 type sequence E description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 16) chain A residue 301 type sequence H description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 17) chain A residue 319 type sequence K description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 18) chain A residue 320 type sequence E description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 19) chain A residue 376 type sequence Y description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 20) chain A residue 381 type sequence Y description BINDING SITE FOR RESIDUE PHE A 900 source : AC4 21) chain A residue 260 type sequence M description BINDING SITE FOR RESIDUE MLI A 980 source : AC5 22) chain A residue 261 type sequence G description BINDING SITE FOR RESIDUE MLI A 980 source : AC5 23) chain A residue 274 type sequence K description BINDING SITE FOR RESIDUE MLI A 980 source : AC5 24) chain A residue 275 type sequence Y description BINDING SITE FOR RESIDUE MLI A 980 source : AC5 25) chain A residue 783 type sequence R description BINDING SITE FOR RESIDUE MLI A 980 source : AC5 26) chain A residue 825 type sequence R description BINDING SITE FOR RESIDUE MLI A 980 source : AC5 27) chain A residue 531 type sequence A description BINDING SITE FOR RESIDUE MLI A 982 source : AC6 28) chain A residue 532 type sequence L description BINDING SITE FOR RESIDUE MLI A 982 source : AC6 29) chain A residue 542 type sequence L description BINDING SITE FOR RESIDUE MLI A 982 source : AC6 30) chain A residue 546 type sequence W description BINDING SITE FOR RESIDUE MLI A 982 source : AC6 31) chain A residue 566 type sequence D description BINDING SITE FOR RESIDUE MLI A 982 source : AC6 32) chain A residue 570 type sequence S description BINDING SITE FOR RESIDUE MLI A 982 source : AC6 33) chain A residue 531 type sequence A description BINDING SITE FOR RESIDUE GOL A 970 source : AC7 34) chain A residue 532 type sequence L description BINDING SITE FOR RESIDUE GOL A 970 source : AC7 35) chain A residue 546 type sequence W description BINDING SITE FOR RESIDUE GOL A 970 source : AC7 36) chain A residue 563 type sequence S description BINDING SITE FOR RESIDUE GOL A 970 source : AC7 37) chain A residue 566 type sequence D description BINDING SITE FOR RESIDUE GOL A 970 source : AC7 38) chain A residue 567 type sequence A description BINDING SITE FOR RESIDUE GOL A 970 source : AC7 39) chain A residue 570 type sequence S description BINDING SITE FOR RESIDUE GOL A 970 source : AC7 40) chain A residue 376 type sequence Y description BINDING SITE FOR RESIDUE GOL A 971 source : AC8 41) chain A residue 378 type sequence L description BINDING SITE FOR RESIDUE GOL A 971 source : AC8 42) chain A residue 382 type sequence E description BINDING SITE FOR RESIDUE GOL A 971 source : AC8 43) chain A residue 262 type sequence A description BINDING SITE FOR RESIDUE GOL A 972 source : AC9 44) chain A residue 293 type sequence R description BINDING SITE FOR RESIDUE GOL A 972 source : AC9 45) chain A residue 297 type sequence H description BINDING SITE FOR RESIDUE GOL A 972 source : AC9 46) chain A residue 298 type sequence E description BINDING SITE FOR RESIDUE GOL A 972 source : AC9 47) chain A residue 381 type sequence Y description BINDING SITE FOR RESIDUE GOL A 972 source : AC9 48) chain A residue 63 type sequence S description BINDING SITE FOR RESIDUE GOL A 973 source : BC1 49) chain A residue 71 type sequence W description BINDING SITE FOR RESIDUE GOL A 973 source : BC1 50) chain A residue 72 type sequence T description BINDING SITE FOR RESIDUE GOL A 973 source : BC1 51) chain A residue 74 type sequence W description BINDING SITE FOR RESIDUE GOL A 973 source : BC1 52) chain A residue 669 type sequence R description BINDING SITE FOR RESIDUE GOL A 973 source : BC1 53) chain A residue 671 type sequence E description BINDING SITE FOR RESIDUE GOL A 973 source : BC1 54) chain A residue 61 type sequence L description BINDING SITE FOR RESIDUE GOL A 974 source : BC2 55) chain A residue 74 type sequence W description BINDING SITE FOR RESIDUE GOL A 974 source : BC2 56) chain A residue 669 type sequence R description BINDING SITE FOR RESIDUE GOL A 974 source : BC2 57) chain A residue 671 type sequence E description BINDING SITE FOR RESIDUE GOL A 974 source : BC2 58) chain A residue 260 type sequence M description BINDING SITE FOR RESIDUE GOL A 975 source : BC3 59) chain A residue 261 type sequence G description BINDING SITE FOR RESIDUE GOL A 975 source : BC3 60) chain A residue 274 type sequence K description BINDING SITE FOR RESIDUE GOL A 975 source : BC3 61) chain A residue 275 type sequence Y description BINDING SITE FOR RESIDUE GOL A 975 source : BC3 62) chain A residue 783 type sequence R description BINDING SITE FOR RESIDUE GOL A 975 source : BC3 63) chain A residue 825 type sequence R description BINDING SITE FOR RESIDUE GOL A 975 source : BC3 64) chain A residue 292 type sequence E description BINDING SITE FOR RESIDUE GOL A 976 source : BC4 65) chain A residue 672 type sequence H description BINDING SITE FOR RESIDUE GOL A 976 source : BC4 66) chain A residue 438 type sequence R description BINDING SITE FOR RESIDUE GOL A 977 source : BC5 67) chain A residue 441 type sequence S description BINDING SITE FOR RESIDUE GOL A 977 source : BC5 68) chain A residue 442 type sequence Q description BINDING SITE FOR RESIDUE GOL A 977 source : BC5 69) chain A residue 475 type sequence Q description BINDING SITE FOR RESIDUE GOL A 977 source : BC5 70) chain A residue 477 type sequence E description BINDING SITE FOR RESIDUE GOL A 977 source : BC5 71) chain A residue 479 type sequence Q description BINDING SITE FOR RESIDUE GOL A 977 source : BC5 72) chain A residue 298 type ACT_SITE sequence E description Proton acceptor => ECO:0000305|PubMed:16885166, ECO:0000305|PubMed:18416562, ECO:0000305|PubMed:19622865 source Swiss-Prot : SWS_FT_FI1 73) chain A residue 294-303 type prosite sequence VIGHEYFHNW description ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW source prosite : PS00142 74) chain A residue 301 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 75) chain A residue 320 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 76) chain A residue 121 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 77) chain A residue 261 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 78) chain A residue 297 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 79) chain A residue 381 type SITE sequence Y description Transition state stabilizer => ECO:0000305 source Swiss-Prot : SWS_FT_FI3

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