eF-site ID 3b2z-ABCDEFGH PDB Code 3b2z Chain A, B, C, D, E, F, G, H click to enlarge Title Crystal Structure of ADAMTS4 (apo form) Classification HYDROLASE Compound ADAMTS-4 Source null (ATS4_HUMAN) Sequence A:  SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFK HPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCA WQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMAD VGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNS KPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITD FLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFG PDSRHCPQLPPPCAALWCSGHHAMCQTKHSPWADGTPCGP AQACMGGRCL B:  LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKH PSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLN TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCD PARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPCISL NGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHC PQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQA CMGGRCL C:  SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFK HPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCA WQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMAD VGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNS KPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITD FLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFG PDSRHCPQLPPPCAALWCSGHAMCQTKHSPWADGTPCGPA QACMGGRCL D:  LSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKH PSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLN TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCD PARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPCISL NGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHC PQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQA CMGGRCL E:  RFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPS IRNPVSLVVTRLVILPQVGPSAAQTLRSFCAWQRGLNTPE DSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPAR SCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPCISLNGP RHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDK PEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPC AALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCL HM F:  SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFK HPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCA WQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMAD VGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNS KPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITD FLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFG PDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTP CGPAQACMGGRCL G:  SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFK HPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCA WQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMAD VGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNS KPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITD FLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFG PDSRHCPQLPPPCAALWCSGHGHAMCQTKHSPWADGTPCG PAQACMGGRCL H:  SRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHP SIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNT PEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDP ARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPCISLN RHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDK PEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPC AALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCL H Description Functional site 1) chain A residue 328 type sequence D description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 2) chain A residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 3) chain A residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 4) chain A residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 5) chain A residue 221 type sequence E description BINDING SITE FOR RESIDUE CA A 2 source : AC2 6) chain A residue 304 type sequence D description BINDING SITE FOR RESIDUE CA A 2 source : AC2 7) chain A residue 311 type sequence D description BINDING SITE FOR RESIDUE CA A 2 source : AC2 8) chain A residue 423 type sequence C description BINDING SITE FOR RESIDUE CA A 2 source : AC2 9) chain A residue 426 type sequence D description BINDING SITE FOR RESIDUE CA A 2 source : AC2 10) chain A residue 221 type sequence E description BINDING SITE FOR RESIDUE CA A 3 source : AC3 11) chain A residue 304 type sequence D description BINDING SITE FOR RESIDUE CA A 3 source : AC3 12) chain A residue 426 type sequence D description BINDING SITE FOR RESIDUE CA A 3 source : AC3 13) chain B residue 328 type sequence D description BINDING SITE FOR RESIDUE ZN B 1 source : AC4 14) chain B residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC4 15) chain B residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC4 16) chain B residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC4 17) chain B residue 221 type sequence E description BINDING SITE FOR RESIDUE CA B 2 source : AC5 18) chain B residue 311 type sequence D description BINDING SITE FOR RESIDUE CA B 2 source : AC5 19) chain B residue 423 type sequence C description BINDING SITE FOR RESIDUE CA B 2 source : AC5 20) chain B residue 426 type sequence D description BINDING SITE FOR RESIDUE CA B 2 source : AC5 21) chain B residue 221 type sequence E description BINDING SITE FOR RESIDUE CA B 3 source : AC6 22) chain B residue 304 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC6 23) chain B residue 426 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC6 24) chain C residue 328 type sequence D description BINDING SITE FOR RESIDUE ZN C 1 source : AC7 25) chain C residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN C 1 source : AC7 26) chain C residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN C 1 source : AC7 27) chain C residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN C 1 source : AC7 28) chain C residue 221 type sequence E description BINDING SITE FOR RESIDUE CA C 2 source : AC8 29) chain C residue 304 type sequence D description BINDING SITE FOR RESIDUE CA C 2 source : AC8 30) chain C residue 311 type sequence D description BINDING SITE FOR RESIDUE CA C 2 source : AC8 31) chain C residue 423 type sequence C description BINDING SITE FOR RESIDUE CA C 2 source : AC8 32) chain C residue 426 type sequence D description BINDING SITE FOR RESIDUE CA C 2 source : AC8 33) chain C residue 221 type sequence E description BINDING SITE FOR RESIDUE CA C 3 source : AC9 34) chain C residue 304 type sequence D description BINDING SITE FOR RESIDUE CA C 3 source : AC9 35) chain C residue 426 type sequence D description BINDING SITE FOR RESIDUE CA C 3 source : AC9 36) chain D residue 328 type sequence D description BINDING SITE FOR RESIDUE ZN D 1 source : BC1 37) chain D residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN D 1 source : BC1 38) chain D residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN D 1 source : BC1 39) chain D residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN D 1 source : BC1 40) chain D residue 221 type sequence E description BINDING SITE FOR RESIDUE CA D 2 source : BC2 41) chain D residue 304 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : BC2 42) chain D residue 311 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : BC2 43) chain D residue 423 type sequence C description BINDING SITE FOR RESIDUE CA D 2 source : BC2 44) chain D residue 426 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : BC2 45) chain D residue 221 type sequence E description BINDING SITE FOR RESIDUE CA D 3 source : BC3 46) chain D residue 304 type sequence D description BINDING SITE FOR RESIDUE CA D 3 source : BC3 47) chain D residue 426 type sequence D description BINDING SITE FOR RESIDUE CA D 3 source : BC3 48) chain E residue 328 type sequence D description BINDING SITE FOR RESIDUE ZN E 1 source : BC4 49) chain E residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN E 1 source : BC4 50) chain E residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN E 1 source : BC4 51) chain E residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN E 1 source : BC4 52) chain E residue 221 type sequence E description BINDING SITE FOR RESIDUE CA E 2 source : BC5 53) chain E residue 304 type sequence D description BINDING SITE FOR RESIDUE CA E 2 source : BC5 54) chain E residue 311 type sequence D description BINDING SITE FOR RESIDUE CA E 2 source : BC5 55) chain E residue 423 type sequence C description BINDING SITE FOR RESIDUE CA E 2 source : BC5 56) chain E residue 426 type sequence D description BINDING SITE FOR RESIDUE CA E 2 source : BC5 57) chain E residue 221 type sequence E description BINDING SITE FOR RESIDUE CA E 3 source : BC6 58) chain E residue 304 type sequence D description BINDING SITE FOR RESIDUE CA E 3 source : BC6 59) chain E residue 426 type sequence D description BINDING SITE FOR RESIDUE CA E 3 source : BC6 60) chain F residue 328 type sequence D description BINDING SITE FOR RESIDUE ZN F 1 source : BC7 61) chain F residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN F 1 source : BC7 62) chain F residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN F 1 source : BC7 63) chain F residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN F 1 source : BC7 64) chain F residue 221 type sequence E description BINDING SITE FOR RESIDUE CA F 2 source : BC8 65) chain F residue 304 type sequence D description BINDING SITE FOR RESIDUE CA F 2 source : BC8 66) chain F residue 311 type sequence D description BINDING SITE FOR RESIDUE CA F 2 source : BC8 67) chain F residue 423 type sequence C description BINDING SITE FOR RESIDUE CA F 2 source : BC8 68) chain F residue 426 type sequence D description BINDING SITE FOR RESIDUE CA F 2 source : BC8 69) chain F residue 221 type sequence E description BINDING SITE FOR RESIDUE CA F 3 source : BC9 70) chain F residue 304 type sequence D description BINDING SITE FOR RESIDUE CA F 3 source : BC9 71) chain F residue 426 type sequence D description BINDING SITE FOR RESIDUE CA F 3 source : BC9 72) chain G residue 328 type sequence D description BINDING SITE FOR RESIDUE ZN G 1 source : CC1 73) chain G residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN G 1 source : CC1 74) chain G residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN G 1 source : CC1 75) chain G residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN G 1 source : CC1 76) chain G residue 221 type sequence E description BINDING SITE FOR RESIDUE CA G 2 source : CC2 77) chain G residue 304 type sequence D description BINDING SITE FOR RESIDUE CA G 2 source : CC2 78) chain G residue 311 type sequence D description BINDING SITE FOR RESIDUE CA G 2 source : CC2 79) chain G residue 423 type sequence C description BINDING SITE FOR RESIDUE CA G 2 source : CC2 80) chain G residue 426 type sequence D description BINDING SITE FOR RESIDUE CA G 2 source : CC2 81) chain G residue 221 type sequence E description BINDING SITE FOR RESIDUE CA G 3 source : CC3 82) chain G residue 304 type sequence D description BINDING SITE FOR RESIDUE CA G 3 source : CC3 83) chain G residue 426 type sequence D description BINDING SITE FOR RESIDUE CA G 3 source : CC3 84) chain H residue 328 type sequence D description BINDING SITE FOR RESIDUE ZN H 1 source : CC4 85) chain H residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN H 1 source : CC4 86) chain H residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN H 1 source : CC4 87) chain H residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN H 1 source : CC4 88) chain H residue 221 type sequence E description BINDING SITE FOR RESIDUE CA H 2 source : CC5 89) chain H residue 304 type sequence D description BINDING SITE FOR RESIDUE CA H 2 source : CC5 90) chain H residue 311 type sequence D description BINDING SITE FOR RESIDUE CA H 2 source : CC5 91) chain H residue 423 type sequence C description BINDING SITE FOR RESIDUE CA H 2 source : CC5 92) chain H residue 426 type sequence D description BINDING SITE FOR RESIDUE CA H 2 source : CC5 93) chain H residue 221 type sequence E description BINDING SITE FOR RESIDUE CA H 3 source : CC6 94) chain H residue 304 type sequence D description BINDING SITE FOR RESIDUE CA H 3 source : CC6 95) chain H residue 426 type sequence D description BINDING SITE FOR RESIDUE CA H 3 source : CC6 96) chain B residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 97) chain C residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 98) chain D residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 99) chain E residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 100) chain F residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 101) chain G residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 102) chain H residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 103) chain A residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1 104) chain A residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 105) chain A residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 106) chain B residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 107) chain B residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 108) chain B residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 109) chain C residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 110) chain C residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 111) chain C residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 112) chain D residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 113) chain D residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 114) chain D residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 115) chain E residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 116) chain E residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 117) chain E residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 118) chain F residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 119) chain F residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 120) chain F residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 121) chain G residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 122) chain G residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 123) chain G residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 124) chain H residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 125) chain H residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 126) chain H residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 127) chain A residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2

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