eF-site ID 3aqv-A PDB Code 3aqv Chain A click to enlarge Title Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound 5'-AMP-activated protein kinase catalytic subunit alpha-2 Source Homo sapiens (Human) (AAPK2_HUMAN) Sequence A:  HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKI LNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTP TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD GEFLPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTL PFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD PLKRATIKDIREHEWFKQDLPSYLFPE Description Functional site 1) chain A residue 43 type sequence A description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 2) chain A residue 45 type sequence K description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 3) chain A residue 94 type sequence E description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 4) chain A residue 95 type sequence Y description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 5) chain A residue 96 type sequence V description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 6) chain A residue 97 type sequence S description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 7) chain A residue 98 type sequence G description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 8) chain A residue 99 type sequence G description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 9) chain A residue 103 type sequence D description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 10) chain A residue 146 type sequence L description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 11) chain A residue 164 type sequence M description BINDING SITE FOR RESIDUE TAK A 1 source : AC1 12) chain A residue 139 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 22 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 45 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 258 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:Q09137 source Swiss-Prot : SWS_FT_FI4 16) chain A residue 22-45 type prosite sequence LGVGTFGKVKIGEHQLTGHKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGVGTFGKVKiGehqltghk..........VAVK source prosite : PS00107 17) chain A residue 135-147 type prosite sequence VVHRDLKPENVLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNVLL source prosite : PS00108

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