eF-site ID 3apr-E PDB Code 3apr Chain E click to enlarge Title BINDING OF A REDUCED PEPTIDE INHIBITOR TO THE ASPARTIC PROTEINASE FROM RHIZOPUS CHINENSIS. IMPLICATIONS FOR A MECHANISM OF ACTION Classification HYDROLASE/HYDROLASE INHIBITOR Compound RHIZOPUSPEPSIN Source null (3APR) Sequence E:  AGVGTVPMTDYGNDIEYYGQVTIGTPGKKFNLDFDTGSSD LWIASTLCTNCGSGQTKYDPNQSSTYQADGRTWSISYGDG SSASGILAKDNVNLGGLLIKGQTIELAKREAASFASGPND GLLGLGFDTITTVRGVKTPMDNLISQGLISRPIFGVYLGK AKNGGGGEYIFGGYDSTKFKGSLTTVPIDNSRGWWGITVD RATVGTSTVASSFDGILDTGTTLLILPNNIAASVARAYGA SDNGDGTYTISCDTSAFKPLVFSINGASFQVSPDSLVFEE FQGQCIAGFGYGNWGFAIIGDTFLKNNYVVFNQGVPEVQI APVAE Description Functional site 1) chain E residue 35 type sequence D description CATALYTICALLY ACTIVE RESIDUES source : CAT 2) chain E residue 218 type sequence D description CATALYTICALLY ACTIVE RESIDUES source : CAT 3) chain E residue 16 type sequence E description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 4) chain E residue 33 type sequence D description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 5) chain E residue 35 type sequence D description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 6) chain E residue 37 type sequence G description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 7) chain E residue 76 type sequence S description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 8) chain E residue 77 type sequence Y description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 9) chain E residue 78 type sequence G description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 10) chain E residue 79 type sequence D description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 11) chain E residue 81 type sequence S description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 12) chain E residue 114 type sequence F description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 13) chain E residue 194 type sequence W description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 14) chain E residue 218 type sequence D description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 15) chain E residue 220 type sequence G description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 16) chain E residue 221 type sequence T description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 17) chain E residue 222 type sequence T description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 18) chain E residue 225 type sequence I description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 19) chain E residue 294 type sequence W description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 20) chain E residue 298 type sequence I description BINDING SITE FOR CHAIN I OF REDUCED PEPTIDE INHIBITOR source : AC1 21) chain E residue 35 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 22) chain E residue 218 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 23) chain E residue 32-43 type prosite sequence LDFDTGSSDLWI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWI source prosite : PS00141 24) chain E residue 215-226 type prosite sequence GILDTGTTLLIL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWI source prosite : PS00141

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