eF-site ID 3ann-B PDB Code 3ann Chain B click to enlarge Title Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) complexed with quinolin-2-ylmethylphosphonic acid Classification OXIDOREDUCTASE Compound 1-deoxy-D-xylulose 5-phosphate reductoisomerase Source Escherichia coli (strain K12) (DXR_ECOLI) Sequence B:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLS GQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT MTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPI AHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS Description Functional site 1) chain B residue 7 type sequence G description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 2) chain B residue 9 type sequence T description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 3) chain B residue 10 type sequence G description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 4) chain B residue 11 type sequence S description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 5) chain B residue 12 type sequence I description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 6) chain B residue 34 type sequence A description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 7) chain B residue 35 type sequence G description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 8) chain B residue 36 type sequence K description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 9) chain B residue 37 type sequence N description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 10) chain B residue 56 type sequence D description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 11) chain B residue 99 type sequence A description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 12) chain B residue 100 type sequence I description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 13) chain B residue 101 type sequence V description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 14) chain B residue 104 type sequence A description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 15) chain B residue 122 type sequence A description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 16) chain B residue 123 type sequence N description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 17) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 18) chain B residue 149 type sequence D description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 19) chain B residue 275 type sequence M description BINDING SITE FOR RESIDUE NDP B 702 source : AC3 20) chain B residue 184 type sequence G description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 21) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 22) chain B residue 208 type sequence H description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 23) chain B residue 210 type sequence N description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 24) chain B residue 211 type sequence W description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 25) chain B residue 221 type sequence S description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 26) chain B residue 226 type sequence N description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 27) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 28) chain B residue 253 type sequence S description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 29) chain B residue 273 type sequence P description BINDING SITE FOR RESIDUE SYE B 801 source : AC4 30) chain B residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 31) chain B residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 32) chain B residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 33) chain B residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 34) chain B residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 35) chain B residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 36) chain B residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 37) chain B residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 38) chain B residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 39) chain B residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 40) chain B residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 41) chain B residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 42) chain B residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 43) chain B residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 44) chain B residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 45) chain B residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 46) chain B residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 47) chain B residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 48) chain B residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 49) chain B residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2

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