eF-site ID 3anm-AB PDB Code 3anm Chain A, B click to enlarge Title Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) complexed with 5-phenylpyridin-2-ylmethylphosphonic acid Classification OXIDOREDUCTASE Compound 1-deoxy-D-xylulose 5-phosphate reductoisomerase Source null (DXR_ECOLI) Sequence A:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLS GQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT MTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPI AHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLASSA B:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLS GQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT MTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPI AHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS Description Functional site 1) chain A residue 184 type sequence G description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 2) chain A residue 185 type sequence S description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 3) chain A residue 208 type sequence H description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 4) chain A residue 210 type sequence N description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 5) chain A residue 211 type sequence W description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 6) chain A residue 221 type sequence S description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 7) chain A residue 226 type sequence N description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 8) chain A residue 227 type sequence K description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 9) chain A residue 253 type sequence S description BINDING SITE FOR RESIDUE SYD A 800 source : AC1 10) chain A residue 7 type sequence G description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 11) chain A residue 9 type sequence T description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 12) chain A residue 10 type sequence G description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 13) chain A residue 11 type sequence S description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 14) chain A residue 12 type sequence I description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 15) chain A residue 34 type sequence A description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 16) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 17) chain A residue 36 type sequence K description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 18) chain A residue 37 type sequence N description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 19) chain A residue 56 type sequence D description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 20) chain A residue 99 type sequence A description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 21) chain A residue 100 type sequence I description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 22) chain A residue 101 type sequence V description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 23) chain A residue 104 type sequence A description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 24) chain A residue 122 type sequence A description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 25) chain A residue 123 type sequence N description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 26) chain A residue 124 type sequence K description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 27) chain A residue 149 type sequence D description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 28) chain A residue 275 type sequence M description BINDING SITE FOR RESIDUE NDP A 410 source : AC2 29) chain B residue 151 type sequence E description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 30) chain B residue 184 type sequence G description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 31) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 32) chain B residue 208 type sequence H description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 33) chain B residue 210 type sequence N description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 34) chain B residue 211 type sequence W description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 35) chain B residue 213 type sequence M description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 36) chain B residue 221 type sequence S description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 37) chain B residue 226 type sequence N description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 38) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 39) chain B residue 253 type sequence S description BINDING SITE FOR RESIDUE SYD B 801 source : AC3 40) chain B residue 7 type sequence G description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 41) chain B residue 9 type sequence T description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 42) chain B residue 10 type sequence G description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 43) chain B residue 11 type sequence S description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 44) chain B residue 12 type sequence I description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 45) chain B residue 34 type sequence A description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 46) chain B residue 35 type sequence G description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 47) chain B residue 36 type sequence K description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 48) chain B residue 37 type sequence N description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 49) chain B residue 56 type sequence D description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 50) chain B residue 99 type sequence A description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 51) chain B residue 100 type sequence I description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 52) chain B residue 101 type sequence V description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 53) chain B residue 104 type sequence A description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 54) chain B residue 122 type sequence A description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 55) chain B residue 123 type sequence N description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 56) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 57) chain B residue 149 type sequence D description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 58) chain B residue 275 type sequence M description BINDING SITE FOR RESIDUE NDP B 410 source : AC4 59) chain A residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 60) chain A residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 61) chain A residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 62) chain A residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 63) chain A residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 64) chain A residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 65) chain A residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 66) chain A residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 67) chain B residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 68) chain B residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 69) chain B residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 70) chain B residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 71) chain B residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 72) chain B residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 73) chain B residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 74) chain B residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 75) chain B residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 76) chain B residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 77) chain B residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 78) chain B residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 79) chain A residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 80) chain B residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 81) chain B residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 82) chain B residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 83) chain B residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 84) chain B residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 85) chain A residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 86) chain A residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 87) chain A residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 88) chain A residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 89) chain A residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 90) chain A residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 91) chain A residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 92) chain A residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 93) chain A residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 94) chain A residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 95) chain A residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 96) chain B residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 97) chain B residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 98) chain B residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2

Display surface Download Links