eF-site ID 3amy-A PDB Code 3amy Chain A click to enlarge Title Crystal structure of human CK2 alpha complexed with apigenin Classification TRANSFERASE Compound Casein kinase II subunit alpha Source Homo sapiens (Human) (CSK21_HUMAN) Sequence A:  SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQL VRKLSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILE NLRGGPNIITLADIVKDTPALVFEHVNNTDFKQLYQTLTD YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK LRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYD YSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ HLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV Description Functional site 1) chain A residue 45 type sequence L description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 2) chain A residue 66 type sequence V description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 3) chain A residue 68 type sequence K description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 4) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 5) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 6) chain A residue 114 type sequence E description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 7) chain A residue 115 type sequence H description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 8) chain A residue 116 type sequence V description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 9) chain A residue 163 type sequence M description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 10) chain A residue 174 type sequence I description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 11) chain A residue 175 type sequence D description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 12) chain A residue 176 type sequence W description BINDING SITE FOR RESIDUE AGI A 336 source : AC1 13) chain A residue 148 type sequence H description BINDING SITE FOR RESIDUE EDO A 337 source : AC2 14) chain A residue 211 type sequence Y description BINDING SITE FOR RESIDUE EDO A 337 source : AC2 15) chain A residue 212 type sequence S description BINDING SITE FOR RESIDUE EDO A 337 source : AC2 16) chain A residue 314 type sequence T description BINDING SITE FOR RESIDUE EDO A 337 source : AC2 17) chain A residue 315 type sequence A description BINDING SITE FOR RESIDUE EDO A 337 source : AC2 18) chain A residue 156 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 19) chain A residue 45 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 68 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 45-68 type prosite sequence LSEVFEAINITNNEKVVVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK source prosite : PS00107 22) chain A residue 152-164 type prosite sequence IMHRDVKPHNVMI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI source prosite : PS00108

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