eF-site ID 3adx-AB PDB Code 3adx Chain A, B click to enlarge Title Human PPARgamma ligand-binding domain in complex with indomethacin and nitro-233 Classification TRANSCRIPTION Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIF QGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGD FMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLN VKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDL RQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDL B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKKSPFVI YDMNSLMMGEDKIKFKKEVAIRIFQGCQFRSVEAVQEITE YAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDG VLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALE LQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKK TETHPLLQEIY Description Functional site 1) chain A residue 264 type sequence F description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 2) chain A residue 267 type sequence I description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 3) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 4) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 5) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 6) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 7) chain A residue 339 type sequence V description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 8) chain A residue 348 type sequence M description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 9) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE NRO A 1 source : AC1 10) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 11) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 12) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 13) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 14) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 15) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 16) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 17) chain A residue 353 type sequence L description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 18) chain A residue 356 type sequence L description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 19) chain A residue 360 type sequence F description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 20) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 21) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 22) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 23) chain A residue 469 type sequence L description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 24) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE IMN A 2 source : AC2 25) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 26) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 27) chain B residue 289 type sequence S description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 28) chain B residue 292 type sequence A description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 29) chain B residue 326 type sequence I description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 30) chain B residue 330 type sequence L description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 31) chain B residue 333 type sequence L description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 32) chain B residue 339 type sequence V description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 33) chain B residue 340 type sequence L description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 34) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 35) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE IMN B 3 source : AC3 36) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 37) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 38) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 39) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 40) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 41) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 42) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 43) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 44) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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