eF-site ID 3adu-AB PDB Code 3adu Chain A, B click to enlarge Title Human PPARgamma ligand-binding domain in complex with 5-methoxy-indole acetate Classification TRANSCRIPTION Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT DKSPFVIYDMNSLMMGEDEVAIRIFQGCQFRSVEAVQEIT EYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKD GVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNAL ELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK KTETDMSLHPLLQEIYKDL B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKSPFVIY DMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSV EAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTML ASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEF AVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHV QLLQVIKKTETSLHPLLQEIY Description Functional site 1) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE MYI A 1 source : AC1 2) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE MYI A 1 source : AC1 3) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE MYI A 1 source : AC1 4) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE MYI A 1 source : AC1 5) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE MYI A 1 source : AC1 6) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE MYI A 1 source : AC1 7) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE MYI A 2 source : AC2 8) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE MYI A 2 source : AC2 9) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE MYI A 2 source : AC2 10) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE MYI A 2 source : AC2 11) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE MYI A 2 source : AC2 12) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE MYI A 2 source : AC2 13) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE MYI A 2 source : AC2 14) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE MYI A 2 source : AC2 15) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE MYI B 3 source : AC3 16) chain B residue 326 type sequence I description BINDING SITE FOR RESIDUE MYI B 3 source : AC3 17) chain B residue 333 type sequence L description BINDING SITE FOR RESIDUE MYI B 3 source : AC3 18) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE MYI B 3 source : AC3 19) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE MYI B 4 source : AC4 20) chain B residue 284 type sequence G description BINDING SITE FOR RESIDUE MYI B 4 source : AC4 21) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE MYI B 4 source : AC4 22) chain B residue 330 type sequence L description BINDING SITE FOR RESIDUE MYI B 4 source : AC4 23) chain B residue 339 type sequence V description BINDING SITE FOR RESIDUE MYI B 4 source : AC4 24) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE MYI B 4 source : AC4 25) chain B residue 348 type sequence M description BINDING SITE FOR RESIDUE MYI B 4 source : AC4 26) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE MYI B 4 source : AC4 27) chain B residue 286 type sequence Q description BINDING SITE FOR RESIDUE MYI B 5 source : AC5 28) chain B residue 289 type sequence S description BINDING SITE FOR RESIDUE MYI B 5 source : AC5 29) chain B residue 323 type sequence H description BINDING SITE FOR RESIDUE MYI B 5 source : AC5 30) chain B residue 327 type sequence Y description BINDING SITE FOR RESIDUE MYI B 5 source : AC5 31) chain B residue 449 type sequence H description BINDING SITE FOR RESIDUE MYI B 5 source : AC5 32) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 33) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 34) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 35) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 36) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 37) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 38) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 39) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 40) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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