eF-site ID 3adt-AB PDB Code 3adt Chain A, B click to enlarge Title Human PPARgamma ligand-binding domain in complex with 5-hydroxy-indole acetate Classification TRANSCRIPTION Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT DKSPFVIYDMNSLMMGEDEVAIRIFQGCQFRSVEAVQEIT EYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKD GVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNAL ELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK KTETDMSLHPLLQEIYKDL B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKSPFVIY DMNSLMMGEDKIKFKHITPLQEVAIRIFQGCQFRSVEAVQ EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLM NKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKF NALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLL QALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQ VIKKTETSLHPLLQEIY Description Functional site 1) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE HID A 2 source : AC1 2) chain A residue 286 type sequence Q description BINDING SITE FOR RESIDUE HID A 2 source : AC1 3) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE HID A 2 source : AC1 4) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE HID A 2 source : AC1 5) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE HID A 2 source : AC1 6) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE HID A 2 source : AC1 7) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE HID A 2 source : AC1 8) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE HID A 2 source : AC1 9) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE HID A 2 source : AC1 10) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE HID A 2 source : AC1 11) chain A residue 222 type sequence Y description BINDING SITE FOR RESIDUE HID A 3 source : AC2 12) chain A residue 227 type sequence P description BINDING SITE FOR RESIDUE HID A 3 source : AC2 13) chain A residue 228 type sequence L description BINDING SITE FOR RESIDUE HID A 3 source : AC2 14) chain A residue 229 type sequence T description BINDING SITE FOR RESIDUE HID A 3 source : AC2 15) chain A residue 230 type sequence K description BINDING SITE FOR RESIDUE HID A 3 source : AC2 16) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE HID A 3 source : AC2 17) chain A residue 295 type sequence E description BINDING SITE FOR RESIDUE HID A 3 source : AC2 18) chain A residue 329 type sequence M description BINDING SITE FOR RESIDUE HID A 3 source : AC2 19) chain A residue 332 type sequence S description BINDING SITE FOR RESIDUE HID A 3 source : AC2 20) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE HID A 3 source : AC2 21) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 22) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 23) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 24) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 25) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 26) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 27) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 28) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 29) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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