eF-site ID 3acj-A PDB Code 3acj Chain A click to enlarge Title Crystal structure of imidazo pyrimidine derivative bound to the kinase domain of human LCK, (Auto-phosphorylated on TYR394) Classification TRANSFERASE Compound Proto-oncogene tyrosine-protein kinase LCK Source Homo sapiens (Human) (LCK_HUMAN) Sequence A:  KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE DNEXTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILL TEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELY QLMRLCWKERPEDRPTFDYLRSVLEDFFTATE Description Functional site 1) chain A residue 298 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 510 source : AC1 2) chain A residue 299 type sequence R description BINDING SITE FOR RESIDUE SO4 A 510 source : AC1 3) chain A residue 377 type sequence S description BINDING SITE FOR RESIDUE SO4 A 510 source : AC1 4) chain A residue 379 type sequence K description BINDING SITE FOR RESIDUE SO4 A 510 source : AC1 5) chain A residue 457 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 510 source : AC1 6) chain A residue 458 type sequence R description BINDING SITE FOR RESIDUE SO4 A 510 source : AC1 7) chain A residue 263 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 511 source : AC2 8) chain A residue 266 type sequence G description BINDING SITE FOR RESIDUE SO4 A 511 source : AC2 9) chain A residue 267 type sequence H description BINDING SITE FOR RESIDUE SO4 A 511 source : AC2 10) chain A residue 489 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 511 source : AC2 11) chain A residue 233 type sequence W description BINDING SITE FOR RESIDUE DMS A 512 source : AC3 12) chain A residue 239 type sequence E description BINDING SITE FOR RESIDUE DMS A 512 source : AC3 13) chain A residue 308 type sequence T description BINDING SITE FOR RESIDUE DMS A 512 source : AC3 14) chain A residue 309 type sequence Q description BINDING SITE FOR RESIDUE DMS A 512 source : AC3 15) chain A residue 251 type sequence L description BINDING SITE FOR RESIDUE KSS A 513 source : AC4 16) chain A residue 271 type sequence A description BINDING SITE FOR RESIDUE KSS A 513 source : AC4 17) chain A residue 317 type sequence E description BINDING SITE FOR RESIDUE KSS A 513 source : AC4 18) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE KSS A 513 source : AC4 19) chain A residue 319 type sequence M description BINDING SITE FOR RESIDUE KSS A 513 source : AC4 20) chain A residue 320 type sequence E description BINDING SITE FOR RESIDUE KSS A 513 source : AC4 21) chain A residue 322 type sequence G description BINDING SITE FOR RESIDUE KSS A 513 source : AC4 22) chain A residue 371 type sequence L description BINDING SITE FOR RESIDUE KSS A 513 source : AC4 23) chain A residue 364 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 251 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 273 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 394 type MOD_RES sequence X description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8139546 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 251-273 type prosite sequence LGAGQFGEVWMGYYNGHTKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGQFGEVWmGyynghtk...........VAVK source prosite : PS00107 28) chain A residue 360-372 type prosite sequence YIHRDLRAANILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLRAANILV source prosite : PS00109

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