eF-site ID 3a6z-AC PDB Code 3a6z Chain A, C click to enlarge Title Crystal structure of Pseudomonas sp. MIS38 lipase (PML) in the open conformation following dialysis against Ca-free buffer Classification HYDROLASE Compound Lipase Source Pseudomonas sp. MIS38 (Q9RBY1_9PSED) Sequence A:  GVYDYKNFGTADSKALFSDAMAITLYSYHNLDNGFAAGYQ HNGFGLGLPATLVTALLGGTDSQGVIPGIPWNPDSEKLAL DAVKKAGWTPITASQLGYDGKTDARGTFFGEKAGYTTAQV EILGKYDAQGHLTEIGIAFRGTSGPRENLILDSIGDVIND LLAAFGPKDYAKNYVGEAFGNLLNDVVAFAKANGLSGKDV LVSGHSLGGLAVNSMADLSGGKWGGFFADSNYIAYASPTQ SSTDKVLNVGYENDPVFRALDGSTFTGASVGVHDAPKESA TDNIVSFNDHYASTAWNLLPFSILNIPTWISHLPTAYGDG MNRIIESKFYDLTSKDSTIIVANLSDPARANTWVQDLNRN AETHKGSTFIIGSDSNDLIQGGSGNDYLEGRAGNDTFRDG GGYNVILGGAGNNTLDLQKSVNTFDFANDGAGNLYVRDAN GGISITRDIGSIVTKEPGFLWGDDVTHSVTASGLKVGSNV TQYDASVKGTNGADTLKAHAGGDWLFGLDGNDHLIGGVGN DVFVGGAGNDLMESGGGADTFLFNGAFGQDRVVGFTSNDK LVFLGVQGVLPNDDFRAHASMVGQDTVLKFGGDSVTLVGV ALNSLSADGIVIA C:  GVYDYKNFGTADSKALFSDAMAITLYSYHNLDNGFAAGYQ HNGFGLGLPATLVTALLGGTDSQGVIPGIPWNPDSEKLAL DAVKKAGWTPITASQLGYDGKTDARGTFFGEKAGYTTAQV EILGKYDAQGHLTEIGIAFRGTSGPRENLILDSIGDVIND LLAAFGPKDYAKNYVGEAFGNLLNDVVAFAKANGLSGKDV LVSGHSLGGLAVNSMADLSGGKWGGFFADSNYIAYASPTQ SSTDKVLNVGYENDPVFRALDGSTFTGASVGVHDAPKESA TDNIVSFNDHYASTAWNLLPFSILNIPTWISHLPTAYGDG MNRIIESKFYDLTSKDSTIIVANLSDPARANTWVQDLNRN AETHKGSTFIIGSDSNDLIQGGSGNDYLEGRAGNDTFRDG GGYNVILGGAGNNTLDLQKSVNTFDFANDGAGNLYVRDAN GGISITRDIGSIVTKEPGFLWGLFKDDVTHSVTASGLKVG SNVTQYDASVKGTNGADTLKAHAGGDWLFGLDGNDHLIGG VGNDVFVGGAGNDLMESGGGADTFLFNGAFGQDRVVGFTS NDKLVFLGVQGVLPNDDFRAHASMVGQDTVLKFGGDSVTL VGVALNSLSADGIVIA Description Functional site 1) chain A residue 253 type sequence E description BINDING SITE FOR RESIDUE CA A 618 source : AC1 2) chain A residue 275 type sequence D description BINDING SITE FOR RESIDUE CA A 618 source : AC1 3) chain A residue 283 type sequence D description BINDING SITE FOR RESIDUE CA A 618 source : AC1 4) chain A residue 284 type sequence N description BINDING SITE FOR RESIDUE CA A 618 source : AC1 5) chain A residue 374 type sequence S description BINDING SITE FOR RESIDUE CA A 620 source : AC2 6) chain A residue 376 type sequence S description BINDING SITE FOR RESIDUE CA A 620 source : AC2 7) chain A residue 378 type sequence D description BINDING SITE FOR RESIDUE CA A 620 source : AC2 8) chain A residue 391 type sequence G description BINDING SITE FOR RESIDUE CA A 620 source : AC2 9) chain A residue 393 type sequence A description BINDING SITE FOR RESIDUE CA A 620 source : AC2 10) chain A residue 396 type sequence D description BINDING SITE FOR RESIDUE CA A 620 source : AC2 11) chain A residue 383 type sequence G description BINDING SITE FOR RESIDUE CA A 621 source : AC3 12) chain A residue 385 type sequence G description BINDING SITE FOR RESIDUE CA A 621 source : AC3 13) chain A residue 387 type sequence D description BINDING SITE FOR RESIDUE CA A 621 source : AC3 14) chain A residue 400 type sequence D description BINDING SITE FOR RESIDUE CA A 621 source : AC3 15) chain A residue 402 type sequence G description BINDING SITE FOR RESIDUE CA A 621 source : AC3 16) chain A residue 405 type sequence N description BINDING SITE FOR RESIDUE CA A 621 source : AC3 17) chain A residue 392 type sequence R description BINDING SITE FOR RESIDUE CA A 622 source : AC4 18) chain A residue 394 type sequence G description BINDING SITE FOR RESIDUE CA A 622 source : AC4 19) chain A residue 396 type sequence D description BINDING SITE FOR RESIDUE CA A 622 source : AC4 20) chain A residue 409 type sequence G description BINDING SITE FOR RESIDUE CA A 622 source : AC4 21) chain A residue 411 type sequence A description BINDING SITE FOR RESIDUE CA A 622 source : AC4 22) chain A residue 414 type sequence N description BINDING SITE FOR RESIDUE CA A 622 source : AC4 23) chain A residue 494 type sequence T description BINDING SITE FOR RESIDUE CA A 623 source : AC5 24) chain A residue 496 type sequence G description BINDING SITE FOR RESIDUE CA A 623 source : AC5 25) chain A residue 498 type sequence D description BINDING SITE FOR RESIDUE CA A 623 source : AC5 26) chain A residue 511 type sequence G description BINDING SITE FOR RESIDUE CA A 623 source : AC5 27) chain A residue 513 type sequence D description BINDING SITE FOR RESIDUE CA A 623 source : AC5 28) chain A residue 516 type sequence D description BINDING SITE FOR RESIDUE CA A 623 source : AC5 29) chain A residue 512 type sequence L description BINDING SITE FOR RESIDUE CA A 624 source : AC6 30) chain A residue 514 type sequence G description BINDING SITE FOR RESIDUE CA A 624 source : AC6 31) chain A residue 516 type sequence D description BINDING SITE FOR RESIDUE CA A 624 source : AC6 32) chain A residue 529 type sequence G description BINDING SITE FOR RESIDUE CA A 624 source : AC6 33) chain A residue 531 type sequence A description BINDING SITE FOR RESIDUE CA A 624 source : AC6 34) chain A residue 534 type sequence D description BINDING SITE FOR RESIDUE CA A 624 source : AC6 35) chain A residue 521 type sequence G description BINDING SITE FOR RESIDUE CA A 625 source : AC7 36) chain A residue 523 type sequence G description BINDING SITE FOR RESIDUE CA A 625 source : AC7 37) chain A residue 525 type sequence D description BINDING SITE FOR RESIDUE CA A 625 source : AC7 38) chain A residue 538 type sequence S description BINDING SITE FOR RESIDUE CA A 625 source : AC7 39) chain A residue 540 type sequence G description BINDING SITE FOR RESIDUE CA A 625 source : AC7 40) chain A residue 543 type sequence D description BINDING SITE FOR RESIDUE CA A 625 source : AC7 41) chain A residue 530 type sequence G description BINDING SITE FOR RESIDUE CA A 626 source : AC8 42) chain A residue 532 type sequence G description BINDING SITE FOR RESIDUE CA A 626 source : AC8 43) chain A residue 534 type sequence D description BINDING SITE FOR RESIDUE CA A 626 source : AC8 44) chain A residue 551 type sequence F description BINDING SITE FOR RESIDUE CA A 626 source : AC8 45) chain A residue 554 type sequence D description BINDING SITE FOR RESIDUE CA A 626 source : AC8 46) chain A residue 118 type sequence T description BINDING SITE FOR RESIDUE CA A 628 source : AC9 47) chain A residue 120 type sequence Q description BINDING SITE FOR RESIDUE CA A 628 source : AC9 48) chain A residue 144 type sequence S description BINDING SITE FOR RESIDUE CA A 628 source : AC9 49) chain A residue 153 type sequence D description BINDING SITE FOR RESIDUE CA A 628 source : AC9 50) chain A residue 157 type sequence D description BINDING SITE FOR RESIDUE CA A 628 source : AC9 51) chain C residue 253 type sequence E description BINDING SITE FOR RESIDUE CA C 618 source : BC1 52) chain C residue 275 type sequence D description BINDING SITE FOR RESIDUE CA C 618 source : BC1 53) chain C residue 283 type sequence D description BINDING SITE FOR RESIDUE CA C 618 source : BC1 54) chain C residue 284 type sequence N description BINDING SITE FOR RESIDUE CA C 618 source : BC1 55) chain C residue 374 type sequence S description BINDING SITE FOR RESIDUE CA C 620 source : BC2 56) chain C residue 376 type sequence S description BINDING SITE FOR RESIDUE CA C 620 source : BC2 57) chain C residue 378 type sequence D description BINDING SITE FOR RESIDUE CA C 620 source : BC2 58) chain C residue 391 type sequence G description BINDING SITE FOR RESIDUE CA C 620 source : BC2 59) chain C residue 393 type sequence A description BINDING SITE FOR RESIDUE CA C 620 source : BC2 60) chain C residue 396 type sequence D description BINDING SITE FOR RESIDUE CA C 620 source : BC2 61) chain C residue 383 type sequence G description BINDING SITE FOR RESIDUE CA C 621 source : BC3 62) chain C residue 385 type sequence G description BINDING SITE FOR RESIDUE CA C 621 source : BC3 63) chain C residue 387 type sequence D description BINDING SITE FOR RESIDUE CA C 621 source : BC3 64) chain C residue 400 type sequence D description BINDING SITE FOR RESIDUE CA C 621 source : BC3 65) chain C residue 402 type sequence G description BINDING SITE FOR RESIDUE CA C 621 source : BC3 66) chain C residue 405 type sequence N description BINDING SITE FOR RESIDUE CA C 621 source : BC3 67) chain C residue 494 type sequence T description BINDING SITE FOR RESIDUE CA C 623 source : BC4 68) chain C residue 496 type sequence G description BINDING SITE FOR RESIDUE CA C 623 source : BC4 69) chain C residue 498 type sequence D description BINDING SITE FOR RESIDUE CA C 623 source : BC4 70) chain C residue 511 type sequence G description BINDING SITE FOR RESIDUE CA C 623 source : BC4 71) chain C residue 513 type sequence D description BINDING SITE FOR RESIDUE CA C 623 source : BC4 72) chain C residue 516 type sequence D description BINDING SITE FOR RESIDUE CA C 623 source : BC4 73) chain C residue 512 type sequence L description BINDING SITE FOR RESIDUE CA C 624 source : BC5 74) chain C residue 514 type sequence G description BINDING SITE FOR RESIDUE CA C 624 source : BC5 75) chain C residue 516 type sequence D description BINDING SITE FOR RESIDUE CA C 624 source : BC5 76) chain C residue 529 type sequence G description BINDING SITE FOR RESIDUE CA C 624 source : BC5 77) chain C residue 531 type sequence A description BINDING SITE FOR RESIDUE CA C 624 source : BC5 78) chain C residue 534 type sequence D description BINDING SITE FOR RESIDUE CA C 624 source : BC5 79) chain C residue 521 type sequence G description BINDING SITE FOR RESIDUE CA C 625 source : BC6 80) chain C residue 523 type sequence G description BINDING SITE FOR RESIDUE CA C 625 source : BC6 81) chain C residue 525 type sequence D description BINDING SITE FOR RESIDUE CA C 625 source : BC6 82) chain C residue 538 type sequence S description BINDING SITE FOR RESIDUE CA C 625 source : BC6 83) chain C residue 540 type sequence G description BINDING SITE FOR RESIDUE CA C 625 source : BC6 84) chain C residue 543 type sequence D description BINDING SITE FOR RESIDUE CA C 625 source : BC6 85) chain C residue 530 type sequence G description BINDING SITE FOR RESIDUE CA C 626 source : BC7 86) chain C residue 532 type sequence G description BINDING SITE FOR RESIDUE CA C 626 source : BC7 87) chain C residue 534 type sequence D description BINDING SITE FOR RESIDUE CA C 626 source : BC7 88) chain C residue 551 type sequence F description BINDING SITE FOR RESIDUE CA C 626 source : BC7 89) chain C residue 554 type sequence D description BINDING SITE FOR RESIDUE CA C 626 source : BC7 90) chain C residue 118 type sequence T description BINDING SITE FOR RESIDUE CA C 628 source : BC8 91) chain C residue 120 type sequence Q description BINDING SITE FOR RESIDUE CA C 628 source : BC8 92) chain C residue 144 type sequence S description BINDING SITE FOR RESIDUE CA C 628 source : BC8 93) chain C residue 153 type sequence D description BINDING SITE FOR RESIDUE CA C 628 source : BC8 94) chain C residue 157 type sequence D description BINDING SITE FOR RESIDUE CA C 628 source : BC8 95) chain A residue 201-210 type prosite sequence VLVSGHSLGG description LIPASE_SER Lipases, serine active site. VLVSGHSLGG source prosite : PS00120 96) chain A residue 507-525 type prosite sequence DWLFGLDGNDHLIGGVGND description HEMOLYSIN_CALCIUM Hemolysin-type calcium-binding region signature. DwLfgldGnDhLiGGvgnD source prosite : PS00330

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