eF-site ID 2zwg-AB PDB Code 2zwg Chain A, B click to enlarge Title Crystal structure of the copper-bound tyrosinase in complex with a caddie protein from streptomyces castaneoglobisporus obtained by soaking the deoxy-form crystal in dioxygen-saturated solution for 12 hours Classification OXIDOREDUCTASE/METAL TRANSPORT Compound Tyrosinase Source Streptomyces castaneoglobisporus (Q83WS1_9ACTO) Sequence A:  TVRKNQATLTADEKRRFVAAVLELKRSGRYDEFVRTHNEF IMSDTDSGERTGHRSPSFLPWHRRFLLDFEQALQSVDSSV TLPYWDWSADRTVRASLWAPDFLGGTGRSTDGRVMDGPFA ASTGNWPINVRVDSRTYLRRSLGGSVAELPTRAEVESVLA ISAYDLPPYNSASEGFRNHLEGWRGVNLHNRVHVWVGGQM ATGVSPNDPVFWLHHAYVDKLWAEWQRRHPDSAYVPTGGT PDVVDLNETMKPWNTVRPADLLDHTAYYTFDALEHH B:  AAPESFDEVYKGRRIQGRPAGYEVFVDGVQLHVMRNADGS WISVVSHXDPVPTPRAAARAAVDELQGAPLLP Description Functional site 1) chain A residue 38 type sequence H description BINDING SITE FOR RESIDUE CU A 501 source : AC1 2) chain A residue 42 type sequence I description BINDING SITE FOR RESIDUE CU A 501 source : AC1 3) chain A residue 54 type sequence H description BINDING SITE FOR RESIDUE CU A 501 source : AC1 4) chain A residue 63 type sequence H description BINDING SITE FOR RESIDUE CU A 501 source : AC1 5) chain B residue 98 type sequence X description BINDING SITE FOR RESIDUE CU A 501 source : AC1 6) chain A residue 190 type sequence H description BINDING SITE FOR RESIDUE CU A 502 source : AC2 7) chain A residue 194 type sequence H description BINDING SITE FOR RESIDUE CU A 502 source : AC2 8) chain A residue 216 type sequence H description BINDING SITE FOR RESIDUE CU A 502 source : AC2 9) chain B residue 98 type sequence X description BINDING SITE FOR RESIDUE CU A 502 source : AC2 10) chain A residue 277 type sequence H description BINDING SITE FOR RESIDUE CU A 504 source : AC3 11) chain A residue 277 type sequence H description BINDING SITE FOR RESIDUE CU A 504 source : AC3 12) chain A residue 165 type sequence Y description BINDING SITE FOR RESIDUE NO3 A 505 source : AC4 13) chain A residue 223 type sequence W description BINDING SITE FOR RESIDUE NO3 A 505 source : AC4 14) chain A residue 226 type sequence W description BINDING SITE FOR RESIDUE NO3 A 505 source : AC4 15) chain A residue 227 type sequence Q description BINDING SITE FOR RESIDUE NO3 A 505 source : AC4 16) chain A residue 234 type sequence A description BINDING SITE FOR RESIDUE NO3 A 505 source : AC4 17) chain A residue 235 type sequence Y description BINDING SITE FOR RESIDUE NO3 A 505 source : AC4 18) chain A residue 263 type sequence L description BINDING SITE FOR RESIDUE NO3 A 505 source : AC4 19) chain A residue 238 type sequence T description BINDING SITE FOR RESIDUE NO3 A 507 source : AC5 20) chain A residue 239 type sequence G description BINDING SITE FOR RESIDUE NO3 A 507 source : AC5 21) chain A residue 246 type sequence D description BINDING SITE FOR RESIDUE NO3 A 507 source : AC5 22) chain A residue 247 type sequence L description BINDING SITE FOR RESIDUE NO3 A 507 source : AC5 23) chain A residue 248 type sequence N description BINDING SITE FOR RESIDUE NO3 A 507 source : AC5 24) chain B residue 50 type sequence K description BINDING SITE FOR RESIDUE NO3 A 507 source : AC5 25) chain A residue 228 type sequence R description BINDING SITE FOR RESIDUE NO3 A 508 source : AC6 26) chain A residue 265 type sequence H description BINDING SITE FOR RESIDUE NO3 A 508 source : AC6 27) chain A residue 266 type sequence T description BINDING SITE FOR RESIDUE NO3 A 508 source : AC6 28) chain A residue 270 type sequence T description BINDING SITE FOR RESIDUE NO3 A 508 source : AC6 29) chain A residue 271 type sequence F description BINDING SITE FOR RESIDUE NO3 A 508 source : AC6 30) chain A residue 274 type sequence L description BINDING SITE FOR RESIDUE NO3 A 508 source : AC6 31) chain A residue 42 type sequence I description BINDING SITE FOR RESIDUE CU B 503 source : AC7 32) chain B residue 82 type sequence H description BINDING SITE FOR RESIDUE CU B 503 source : AC7 33) chain B residue 84 type sequence M description BINDING SITE FOR RESIDUE CU B 503 source : AC7 34) chain B residue 97 type sequence H description BINDING SITE FOR RESIDUE CU B 503 source : AC7 35) chain A residue 125 type sequence G description BINDING SITE FOR RESIDUE NO3 B 506 source : AC8 36) chain A residue 128 type sequence P description BINDING SITE FOR RESIDUE NO3 B 506 source : AC8 37) chain B residue 103 type sequence T description BINDING SITE FOR RESIDUE NO3 B 506 source : AC8 38) chain B residue 105 type sequence R description BINDING SITE FOR RESIDUE NO3 B 506 source : AC8 39) chain B residue 106 type sequence A description BINDING SITE FOR RESIDUE NO3 B 506 source : AC8 40) chain B residue 109 type sequence R description BINDING SITE FOR RESIDUE NO3 B 506 source : AC8 41) chain A residue 54-71 type prosite sequence HRSPSFLPWHRRFLLDFE description TYROSINASE_1 Tyrosinase CuA-binding region signature. Hrsps.FLpWHRrfLldfE source prosite : PS00497 42) chain A residue 209-220 type prosite sequence DPVFWLHHAYVD description TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPvFWlhHayvD source prosite : PS00498

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