eF-site ID 2zw9-B PDB Code 2zw9 Chain B click to enlarge Title Crystal structure of tRNA wybutosine synthesizing enzyme TYW4 Classification TRANSFERASE Compound Leucine carboxyl methyltransferase 2 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (LCMT2_YEAST) Sequence B:  YADLAIQGTNNSSIASKRSVELLYLPKLSSANNFQMDKNN KLLEYFKFFVPKKIKRSPCINRGYWLRLFAIRSRLNSIIE QTPQDKKIVVVNLGCGYDPLPFQLLDTNNIQSQQYHDRVS FIDIDYSDLLKIKIELIKTIPELSKIIGLSNVDFLTTPKY LARPCDLNDSKMFSTLLNECQLYDPNVVKVFVAEVSLAYM KPERSDSIIEATSKMENSHFIILEQLIPKGPFEPFSKQML AHFKRNDSPLQSVLKYNTIESQVQRFNKLGFAYVNVGDMF QLWESADEATKKELLKVEPFDELEEFHLFCHHYVLCHATN YKEFAFTQGFLFDRSISEINLTVDEDYQLLECECPINRKF GDVDVAGNDVFYMGGSNPYRVNEILQLSIHYDKIDMKNIE VSSSEVPVARMCHTFTTISRNNQLLLIGGRKAPHQGLSDN WIFDMKTREWSMIKSLSHTRFRHSACSLPDGNVLILGGVT EGPAMLLYNVTEEIFKDVTPKDEFFQNSLVSAGLEFDPVS KQGIILGGGFMDQTTVSDKAIIFKYDAENATEPITVIKKL QHPLFQRYGSQIKYITPRKLLIVGGTSPSGLFDRTNSIIS LDPLSETLTSIPISRRIWEDHSLMLAGFSLVSTSMGTIHI IGGGATCYGFGSVTNVGLKLIAIA Description Functional site 1) chain B residue 27 type sequence I description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 2) chain B residue 28 type sequence Q description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 3) chain B residue 30 type sequence T description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 4) chain B residue 31 type sequence N description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 5) chain B residue 34 type sequence S description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 6) chain B residue 38 type sequence K description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 7) chain B residue 88 type sequence R description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 8) chain B residue 115 type sequence G description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 9) chain B residue 116 type sequence C description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 10) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 11) chain B residue 146 type sequence D description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 12) chain B residue 147 type sequence Y description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 13) chain B residue 150 type sequence L description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 14) chain B residue 195 type sequence C description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 15) chain B residue 196 type sequence D description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 16) chain B residue 197 type sequence L description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 17) chain B residue 198 type sequence N description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 18) chain B residue 224 type sequence E description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 19) chain B residue 225 type sequence V description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 20) chain B residue 226 type sequence S description BINDING SITE FOR RESIDUE SAM B 801 source : AC2 21) chain B residue 88 type ACT_SITE sequence R description Proton donor; for both methylation and methoxycarbonylation activities => ECO:0000269|PubMed:19287006 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 229 type ACT_SITE sequence Y description Proton acceptor; for methoxycarbonylation activity => ECO:0000305|PubMed:19287006 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 146 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 24) chain B residue 196 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 25) chain B residue 224 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 26) chain B residue 38 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 27) chain B residue 88 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 28) chain B residue 115 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3

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