eF-site ID 2zw9-A PDB Code 2zw9 Chain A click to enlarge Title Crystal structure of tRNA wybutosine synthesizing enzyme TYW4 Classification TRANSFERASE Compound Leucine carboxyl methyltransferase 2 Source null (LCMT2_YEAST) Sequence A:  QERRKKYADLAIQGTNNSSIASKRSVELLYLPKLSSANNF QMDKNNKLLEYFKFFVPKKIKRSPCINRGYWLRLFAIRSR LNSIIEQTPQDKKIVVVNLGCGYDPLPFQLLDTNNIQSQQ YHDRVSFIDIDYSDLLKIKIELIKTIPELSKIIGLSNVDF LTTPKYLARPCDLNDSKMFSTLLNECQLYDPNVVKVFVAE VSLAYMKPERSDSIIEATSKMENSHFIILEQLIPKGPFEP FSKQMLAHFKRNDSPLQSVLKYNTIESQVQRFNKLGFAYV NVGDMFQLWESADEATKKELLKVEPFDELEEFHLFCHHYV LCHATNYKEFAFTQGFLFDRSISEINLTVDEDYQLLECEC PINRKFGDVDVAGNDVFYMGGSNPYRVNEILQLSIHYDKI DMKNIEVSSSEVPVARMCHTFTTISRNNQLLLIGGRKAPH QGLSDNWIFDMKTREWSMIKSLSHTRFRHSACSLPDGNVL ILGGVTEGPAMLLYNVTEEIFKDVTPKDEFFQNSLVSAGL EFDPVSKQGIILGGGFMDQTTVSDKAIIFKYDAENATEPI TVIKKLQHPLFQRYGSQIKYITPRKLLIVGGTSPSGLFDR TNSIISLDPLSETLTSIPISRRIWEDHSLMLAGFSLVSTT IHIIGGGATCYGFGSVTNVGLKLIAI Description Functional site 1) chain A residue 27 type sequence I description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 2) chain A residue 30 type sequence T description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 3) chain A residue 31 type sequence N description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 4) chain A residue 34 type sequence S description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 5) chain A residue 38 type sequence K description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 6) chain A residue 88 type sequence R description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 7) chain A residue 115 type sequence G description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 8) chain A residue 116 type sequence C description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 9) chain A residue 117 type sequence G description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 10) chain A residue 146 type sequence D description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 11) chain A residue 147 type sequence Y description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 12) chain A residue 150 type sequence L description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 13) chain A residue 195 type sequence C description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 14) chain A residue 196 type sequence D description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 15) chain A residue 197 type sequence L description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 16) chain A residue 198 type sequence N description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 17) chain A residue 224 type sequence E description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 18) chain A residue 225 type sequence V description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 19) chain A residue 226 type sequence S description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 20) chain A residue 229 type sequence Y description BINDING SITE FOR RESIDUE SAM A 801 source : AC1 21) chain A residue 88 type ACT_SITE sequence R description Proton donor; for both methylation and methoxycarbonylation activities => ECO:0000269|PubMed:19287006 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 229 type ACT_SITE sequence Y description Proton acceptor; for methoxycarbonylation activity => ECO:0000305|PubMed:19287006 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 115 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 24) chain A residue 146 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 25) chain A residue 196 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3 26) chain A residue 224 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 27) chain A residue 38 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 28) chain A residue 88 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3

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