eF-site ID 2zvw-ABCDEFGHIJKLMNOP PDB Code 2zvw Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P click to enlarge Title Crystal structure of Proliferating cell nuclear antigen 2 and Short peptide from human P21 Classification DNA BINDING PROTEIN Compound Proliferating cell nuclear antigen 2 Source Arabidopsis thaliana (Mouse-ear cress) (CDN1A_HUMAN) Sequence A:  MLELRLVQGSLLKKVLEAVKDLVNDANFDCSTTGFSLQAM DSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLGNMSKMLK CAGNDDIITIKADDGSDTVTFMFESPTQDKIADFEMKLMD IDSEHLGIPDAEYHSIVRMPSGEFSRICKDLSSIGDTVVI SVTKEGVKFSTAGDIGTANIVLRQNTTVDKPEDAIVIEMN EPVSLSFALRYMNSFTKATPLSETVTISLSSELPVVVEYK VAEMGYIRYYLAPKI B:  MLELRLVQGSLLKKVLEAVKDLVNDANFDCSTTGFSLQAM DSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLGNMSKMLK CAGNDDIITIKADDGSDTVTFMFESPTQDKIADFEMKLMD IDSEHLGIPDAEYHSIVRMPSGEFSRICKDLSSIGDTVVI SVTKEGVKFSTAGDIGTANIVLRQNTTVDKPEDAIVIEMN EPVSLSFALRYMNSFTKATPLSETVTISLSSELPVVVEYK VAEMGYIRYYLAPKI C:  MLELRLVQGSLLKKVLEAVKDLVNDANFDCSTTGFSLQAM DSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLGNMSKMLK CAGNDDIITIKADDGSDTVTFMFESPTQDKIADFEMKLMD IDSEHLGIPDAEYHSIVRMPSGEFSRICKDLSSIGDTVVI SVTKEGVKFSTAGDIGTANIVLRQNTTVDKPEDAIVIEMN EPVSLSFALRYMNSFTKATPLSETVTISLSSELPVVVEYK VAEMGYIRYYLAPKI D:  MLELRLVQGSLLKKVLEAVKDLVNDANFDCSTTGFSLQAM DSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLGNMSKMLK CAGNDDIITIKADDGSDTVTFMFESPTQDKIADFEMKLMD IDSEHLGIPDAEYHSIVRMPSGEFSRICKDLSSIGDTVVI SVTKEGVKFSTAGDIGTANIVLRQNTTVDKPEDAIVIEMN EPVSLSFALRYMNSFTKATPLSETVTISLSSELPVVVEYK VAEMGYIRYYLAPKI E:  MLELRLVQGSLLKKVLEAVKDLVNDANFDCSTTGFSLQAM DSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLGNMSKMLK CAGNDDIITIKADDGSDTVTFMFESPTQDKIADFEMKLMD IDSEHLGIPDAEYHSIVRMPSGEFSRICKDLSSIGDTVVI SVTKEGVKFSTAGDIGTANIVLRQNTTVDKPEDAIVIEMN EPVSLSFALRYMNSFTKATPLSETVTISLSSELPVVVEYK VAEMGYIRYYLAPKI F:  MLELRLVQGSLLKKVLEAVKDLVNDANFDCSTTGFSLQAM DSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLGNMSKMLK CAGNDDIITIKADDGSDTVTFMFESPTQDKIADFEMKLMD IDSEHLGIPDAEYHSIVRMPSGEFSRICKDLSSIGDTVVI SVTKEGVKFSTAGDIGTANIVLRQNTTVDKPEDAIVIEMN EPVSLSFALRYMNSFTKATPLSETVTISLSSELPVVVEYK VAEMGYIRYYLAPKI G:  MLELRLVQGSLLKKVLEAVKDLVNDANFDCSTTGFSLQAM DSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLGNMSKMLK CAGNDDIITIKADDGSDTVTFMFESPTQDKIADFEMKLMD IDSEHLGIPDAEYHSIVRMPSGEFSRICKDLSSIGDTVVI SVTKEGVKFSTAGDIGTANIVLRQNTTVDKPEDAIVIEMN EPVSLSFALRYMNSFTKATPLSETVTISLSSELPVVVEYK VAEMGYIRYYLAPKI H:  MLELRLVQGSLLKKVLEAVKDLVNDANFDCSTTGFSLQAM DSSHVALVSLLLRSEGFEHYRCDRNLSMGMNLGNMSKMLK CAGNDDIITIKADDGSDTVTFMFESPTQDKIADFEMKLMD IDSEHLGIPDAEYHSIVRMPSGEFSRICKDLSSIGDTVVI SVTKEGVKFSTAGDIGTANIVLRQNTTVDKPEDAIVIEMN EPVSLSFALRYMNSFTKATPLSETVTISLSSELPVVVEYK VAEMGYIRYYLAPKI I:  RQTSMTDFYHS J:  RQTSMTDFYHS K:  RQTSMTDFYHS L:  RQTSMTDFYHS M:  RQTSMTDFYHS N:  RQTSMTDFYHS O:  RQTSMTDFYHS P:  RQTSMTDFYHS Description Functional site 1) chain A residue 208 type sequence A description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 2) chain A residue 210 type sequence R description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 3) chain A residue 254 type sequence K description BINDING SITE FOR RESIDUE SO4 A 901 source : AC1 4) chain B residue 156 type sequence D description BINDING SITE FOR RESIDUE SO4 B 911 source : AC2 5) chain B residue 208 type sequence A description BINDING SITE FOR RESIDUE SO4 B 911 source : AC2 6) chain B residue 210 type sequence R description BINDING SITE FOR RESIDUE SO4 B 911 source : AC2 7) chain B residue 254 type sequence K description BINDING SITE FOR RESIDUE SO4 B 911 source : AC2 8) chain C residue 156 type sequence D description BINDING SITE FOR RESIDUE SO4 C 921 source : AC3 9) chain C residue 208 type sequence A description BINDING SITE FOR RESIDUE SO4 C 921 source : AC3 10) chain C residue 210 type sequence R description BINDING SITE FOR RESIDUE SO4 C 921 source : AC3 11) chain C residue 254 type sequence K description BINDING SITE FOR RESIDUE SO4 C 921 source : AC3 12) chain D residue 210 type sequence R description BINDING SITE FOR RESIDUE SO4 D 931 source : AC4 13) chain D residue 254 type sequence K description BINDING SITE FOR RESIDUE SO4 D 931 source : AC4 14) chain E residue 210 type sequence R description BINDING SITE FOR RESIDUE SO4 E 941 source : AC5 15) chain F residue 210 type sequence R description BINDING SITE FOR RESIDUE SO4 F 951 source : AC6 16) chain F residue 254 type sequence K description BINDING SITE FOR RESIDUE SO4 F 951 source : AC6 17) chain H residue 210 type sequence R description BINDING SITE FOR RESIDUE SO4 H 961 source : AC7 18) chain H residue 254 type sequence K description BINDING SITE FOR RESIDUE SO4 H 961 source : AC7 19) chain I residue 145 type MOD_RES sequence T description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683 source Swiss-Prot : SWS_FT_FI1 20) chain J residue 145 type MOD_RES sequence T description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683 source Swiss-Prot : SWS_FT_FI1 21) chain K residue 145 type MOD_RES sequence T description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683 source Swiss-Prot : SWS_FT_FI1 22) chain L residue 145 type MOD_RES sequence T description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683 source Swiss-Prot : SWS_FT_FI1 23) chain M residue 145 type MOD_RES sequence T description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683 source Swiss-Prot : SWS_FT_FI1 24) chain N residue 145 type MOD_RES sequence T description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683 source Swiss-Prot : SWS_FT_FI1 25) chain O residue 145 type MOD_RES sequence T description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683 source Swiss-Prot : SWS_FT_FI1 26) chain P residue 145 type MOD_RES sequence T description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683 source Swiss-Prot : SWS_FT_FI1 27) chain I residue 146 type MOD_RES sequence S description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316 source Swiss-Prot : SWS_FT_FI2 28) chain J residue 146 type MOD_RES sequence S description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316 source Swiss-Prot : SWS_FT_FI2 29) chain K residue 146 type MOD_RES sequence S description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316 source Swiss-Prot : SWS_FT_FI2 30) chain L residue 146 type MOD_RES sequence S description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316 source Swiss-Prot : SWS_FT_FI2 31) chain M residue 146 type MOD_RES sequence S description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316 source Swiss-Prot : SWS_FT_FI2 32) chain N residue 146 type MOD_RES sequence S description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316 source Swiss-Prot : SWS_FT_FI2 33) chain O residue 146 type MOD_RES sequence S description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316 source Swiss-Prot : SWS_FT_FI2 34) chain P residue 146 type MOD_RES sequence S description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 61-79 type prosite sequence RCDRNLSMGMNLGNMSKML description PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlsMgmnLgNMsKML source prosite : PS00293 36) chain A residue 34-57 type prosite sequence GFSLQAMDSSHVALVSLLLRSEGF description PCNA_1 Proliferating cell nuclear antigen signature 1. GFsLqAMDsSHVaLVsLlLrsegF source prosite : PS01251

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