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Title
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Crystal structure of Galacto-N-biose/Lacto-N-biose I phosphorylase in complex with GlcNAc and sulfate |
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Classification
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TRANSFERASE |
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Compound
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Lacto-N-biose phosphorylase |
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Source
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(Q5NU17_BIFLO) |
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Sequence
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A: |
STGRFTLPSEENFAEKTKELAELWGADAIRNDEAVLALGK
KIYNAYFPTRAHNEWITLHMDETPQVYLLTDRILAESDTV
DIPLMESFFAEQLKPNRDADPHKYWEVVDRTTGEVVDSAN
WTLDADEDTVHVSGVAAWHEYTVSFLAYIIWDPVEMYNHL
TNDWGDKEHEIPFDIYHPATRKFVFDTFEQWLKDSPQTDV
VRFTTFFYQFTLLFDEKRREKVVDWFGCACTVSPRALDDF
EAKYGYRLRPEDFVDGGAYNSAWRVPRKAQRDWIDFLSGF
VRENVKQLADMSHAAGKEAMMFLGDQWIGTEPYKDGFDEL
GLDAVVGSIGDGTTTRMIADIPGVKYTEGRFLPYFFPDTF
YEGNDPSIEGLDNWRKARRAILRSPISRMGYGGYLSLAAK
FPKFVDTVTHIANEFRDIHDRTGGVAAEGELNVAILNSWG
KMRSWMAFTVAHALPNKQTYSYYGILESLSGMRVNVRFIS
FDDVLAHGIDSDIDVIINGGPVDTAFTGGDVWTNPKLVET
VRAWVRGGGAFVGVGEPSSAPRFQTGRFFQLADVIGVDEE
RYQTLSVDKYFPPVVPDHFITADVPVDPAAREAWEQAGYR
IPLSGCGGGQSIKPLGGIDFGEPVLNTYPVNENVTLLRAD
GGQVQLATNDYGKGRGVYISGLPYSAANARLLERVLFYAS
HNEDKYAAWSSSNPECEVAHFPEQGLYCVINNTDQPQKTT
VTLADGTTEDFDLPDSGIAWREALE
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| B: |
STGRFTLPSEENFAEKTKELAELWGADAIRLALGKKIYNA
YFPTRAHNEWITLHMDETPQVYLLTDRILAESDTVDIPLM
ESFFAEQLKPNRDADPHKYWEVVDRTTGEVVDSANWTLDA
DEDTVHVSGVAAWHEYTVSFLAYIIWDPVEMYNHLTNDWG
DKEHEIPFDIYHPATRKFVFDTFEQWLKDSPQTDVVRFTT
FFYQFTLLFDEKRREKVVDWFGCACTVSPRALDDFEAKYG
YRLRPEDFVDGGAYNSAWRVPRKAQRDWIDFLSGFVRENV
KQLADMSHAAGKEAMMFLGDQWIGTEPYKDGFDELGLDAV
VGSIGDGTTTRMIADIPGVKYTEGRFLPYFFPDGNDPSIE
GLDNWRKARRAILRSPISRMGYGGYLSLAAKFPKFVDTVT
HIANEFRDIHDRTGGVAAEGELNVAILNSWGKMRSWMAFT
VAHALPNKQTYSYYGILESLSGMRVNVRFISFDDVLAHGI
DSDIDVIINGGPVDTAFTGGDVWTNPKLVETVRAWVRGGG
AFVGVGEPSSAPRFQTGRFFQLADVIGVDEERYQTLSVDK
YFPPVVPDHFITADVPVDPAAREAWEQAGYRIPLSGCGGG
QSIKPLGGIDFGEPVLNTYPVNENVTLLRADGGQVQLATN
DYGKGRGVYISGLPYSAANARLLERVLFYASHNEDKYAAW
SSSNPECEVAHFPEQGLYCVINNTDQPQKTTVTLADGTTE
DFDLPDSGIAWREA
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| C: |
STGRFTLPSEENFAEKTKELAELWGADAIRNSDDEAVLAL
GKKIYNAYFPTRAHNEWITLHMDETPQVYLLTDRILAESD
TVDIPLMESFFAEQLKPNRDADPHKYWEVVDRTTGEVVDS
ANWTLDADEDTVHVSGVAAWHEYTVSFLAYIIWDPVEMYN
HLTNDWGDKEHEIPFDIYHPATRKFVFDTFEQWLKDSPQT
DVVRFTTFFYQFTLLFDEKRREKVVDWFGCACTVSPRALD
DFEAKYGYRLRPEDFVDGGAYNSAWRVPRKAQRDWIDFLS
GFVRENVKQLADMSHAAGKEAMMFLGDQWIGTEPYKDGFD
ELGLDAVVGSIGDGTTTRMIADIPGVKYTEGRFLPYFFPD
TFYEGNDPSIEGLDNWRKARRAILRSPISRMGYGGYLSLA
AKFPKFVDTVTHIANEFRDIHDRTGGVAAEGELNVAILNS
WGKMRSWMAFTVAHALPNKQTYSYYGILESLSGMRVNVRF
ISFDDVLAHGIDSDIDVIINGGPVDTAFTGGDVWTNPKLV
ETVRAWVRGGGAFVGVGEPSSAPRFQTGRFFQLADVIGVD
EERYQTLSVDKYFPPVVPDHFITADVPVDPAAREAWEQAG
YRIPLSGCGGGQSIKPLGGIDFGEPVLNTYPVNENVTLLR
ADGGQVQLATNDYGKGRGVYISGLPYSAANARLLERVLFY
ASHNEDKYAAWSSSNPECEVAHFPEQGLYCVINNTDQPQK
TTVTLADGTTEDFDLPDSGIAWREALEH
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| D: |
GRFTLPSELAELWGADAIRNLGKKIYNAYFPTRAHNEWIT
LHMDETPQVYLLTDRILAESDTVDIPLMESFFAEQLKPNR
DADPHKYWEVVDRTTGEVVDSANWTLDADEDTVHVSGVAA
WHEYTVSFLAYIIWDPVEMYNHLTNDWGDKEHEIPFDIYH
PATRKFVFDTFEQWLKDSPQTDVVRFTTFFYQFTLLFDEK
RREKVVDWFGCACTVSPRALDDFEAKYGYRLRPEDFVDGG
AYNSAWRVPRKAQRDWIDFLSGFVRENVKQLADMSHAAGK
EAMMFLGDQWIGTEPYKDGFDELGLDAVVGSIGDGTTTRM
IADIPGVKYTEGRFLPYFFPDTFYEGNSIEGLDNWRKARR
AILRSPISRMGYGAKFPKFVDTVTHIANEFRDIHVAAEGE
LNVAILNSWGKMRSWMAFTVAHALPNKQTYSYYGILESLS
GMRVNVRFISFDDVLAHGIDSDIDVIINGGPVDTAFTGGD
VWTNPKLVETVRAWVRGGGAFVGVGEPSSAPRFQTGRFFQ
LADVIGVDEERYQTLSVDKYFPPVVPDHFITADVPVDPAA
REAWEQAGYRIPLSGCGGGQSIKPLGGIDFGEPVLNTYPV
NENVTLLRADGGQVQLATNDYGKGRGVYISGLPYSAANAR
LLERVLFYASHNEDKYAAWSSSNPECEVAHFPEQGLYCVI
NNTDQPQKTTVTLADGTTEDFDLPDSGIAWREA
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Description
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