eF-site ID 2zq8-A PDB Code 2zq8 Chain A click to enlarge Title Apo structure of class a beta-lactamase Toho-1 R274N/R276N double mutant Classification HYDROLASE Compound Beta-lactamase Toho-1 Source Escherichia coli (BLT1_ECOLX) Sequence A:  NSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFA MCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNP IAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDK VTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMA QTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPK SWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPE QKAENRNDILAAAAKIVTHGF Description Functional site 1) chain A residue 229 type sequence W description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 2) chain A residue 252 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 3) chain A residue 254 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 4) chain A residue 255 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 5) chain A residue 256 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 6) chain A residue 290 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 7) chain A residue 82 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 8) chain A residue 198 type sequence A description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 9) chain A residue 274 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 10) chain A residue 276 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 11) chain A residue 277 type sequence D description BINDING SITE FOR RESIDUE SO4 A 2 source : AC2 12) chain A residue 52 type sequence A description BINDING SITE FOR RESIDUE SO4 A 3 source : AC3 13) chain A residue 178 type sequence R description BINDING SITE FOR RESIDUE SO4 A 3 source : AC3 14) chain A residue 70 type sequence S description BINDING SITE FOR RESIDUE SO4 A 4 source : AC4 15) chain A residue 130 type sequence S description BINDING SITE FOR RESIDUE SO4 A 4 source : AC4 16) chain A residue 234 type sequence K description BINDING SITE FOR RESIDUE SO4 A 4 source : AC4 17) chain A residue 235 type sequence T description BINDING SITE FOR RESIDUE SO4 A 4 source : AC4 18) chain A residue 236 type sequence G description BINDING SITE FOR RESIDUE SO4 A 4 source : AC4 19) chain A residue 237 type sequence S description BINDING SITE FOR RESIDUE SO4 A 4 source : AC4 20) chain A residue 88 type sequence K description BINDING SITE FOR RESIDUE SO4 A 5 source : AC5 21) chain A residue 89 type sequence H description BINDING SITE FOR RESIDUE SO4 A 5 source : AC5 22) chain A residue 92 type sequence N description BINDING SITE FOR RESIDUE SO4 A 5 source : AC5 23) chain A residue 234 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 24) chain A residue 66-81 type prosite sequence FAMCSTSKVMAAAAVL description BETA_LACTAMASE_A Beta-lactamase class-A active site. FaMCSTsKvmaAAAVL source prosite : PS00146 25) chain A residue 70 type ACT_SITE sequence S description Acyl-ester intermediate source Swiss-Prot : SWS_FT_FI1

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