|
|
eF-site ID
|
2zox-A |
|
PDB Code
|
2zox |
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Chain
|
A |
|
click to enlarge
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Title
|
Crystal Structure of the Covalent Intermediate of Human Cytosolic beta-Glucosidase |
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Classification
|
HYDROLASE |
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Compound
|
Cytosolic beta-glucosidase |
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Source
|
Homo sapiens (Human) (GBA3_HUMAN) |
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Sequence
|
A: |
MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGG
ERVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSW
SRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYH
FDLPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQW
ITINQANVLSVMSYDLGMFPPGIPHFGTGGYQAAHNLIKA
HARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQ
EAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQG
YPSSRLPEFTEEEKKMIKGTADFFAVQYYTTRLIKYQENK
KGELGILQDAEIEFFPDPSWKNVDWIYVVPWGVCKLLKYI
KDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQEL
FKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDF
EDPARPRVPYTSAKEYAKIIRNNGLE
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
165 |
| type |
ACT_SITE |
| sequence |
Q
|
| description |
Proton donor => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
373 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Nucleophile => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
17 |
| type |
BINDING |
| sequence |
Q
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
A |
| residue |
120 |
| type |
BINDING |
| sequence |
H
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
A |
| residue |
164 |
| type |
BINDING |
| sequence |
N
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
A |
| residue |
309 |
| type |
BINDING |
| sequence |
Y
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
A |
| residue |
417 |
| type |
BINDING |
| sequence |
W
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
8)
|
chain |
A |
| residue |
7-21 |
| type |
prosite |
| sequence |
FGWAAATAAYQVEGG
|
| description |
GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FgWAaAtAAYQvEgG
|
| source |
prosite : PS00653
|
|
|
9)
|
chain |
A |
| residue |
424 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|